Robert Hemke
A5078516450- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Bone and Joint Diseases
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Adolescent and Pediatric Healthcare
- SARS-CoV-2 and COVID-19 Research
- Orthopedic Infections and Treatments
- Spondyloarthritis Studies and Treatments
- Nutrition and Health in Aging
- Lymphoma Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Foot and Ankle Surgery
- Medical Imaging Techniques and Applications
- Long-Term Effects of COVID-19
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Sports injuries and prevention
- Infectious Diseases and Tuberculosis
- Inflammasome and immune disorders
- Neurogenetic and Muscular Disorders Research
- Diabetes and associated disorders
- Elbow and Forearm Trauma Treatment
Amsterdam University Medical Centers
2018-2025
Health & Safety in Sports
2022-2024
University of Amsterdam
2015-2024
Invitae (United States)
2023-2024
Amsterdam UMC Location University of Amsterdam
2013-2023
Academic Center for Evidence-Based Sports Medicine
2022
Emma Kinderziekenhuis
2013-2020
Harvard University
2019-2020
Massachusetts General Hospital
2019-2020
Corvid Technologies (United States)
2020
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential IgG function, shows variable composition in humans. Afucosylated variants already used anticancer therapeutic their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated (approximately 6% of total humans) specifically formed enveloped viruses but generally not other antigens. This mediates...
BackgroundMortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight pathways associated unfavourable outcome may lead to new treatment strategies.MethodsWe performed a prospective cohort study of COVID-19 admitted general ward or ICU who underwent serial blood sampling. To provide insight involved disease progression, associations were estimated between risk and measurements 64 biomarkers potential important infection (inflammation,...
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections often cause only mild disease that may evoke relatively low Ab titers compared with patients admitted to hospitals. Generally, total bridging assays combine good sensitivity high specificity. Therefore, we developed sensitive for detection of SARS-CoV-2 Abs the receptor-binding domain (RBD) and nucleocapsid protein in addition conventional isotype-specific assays. kinetics was assessed PCR-confirmed, hospitalized...
Rationale: Bacterial lung microbiota are correlated with inflammation and acute respiratory distress syndrome (ARDS) altered in severe coronavirus disease (COVID-19). However, the association between (including fungi) resolution of ARDS COVID-19 remains unclear. We hypothesized that increased bacterial fungal burdens related to nonresolving mortality COVID-19. Objectives: To determine relation clinical outcomes COVID-19–related ARDS. Methods: This observational cohort study enrolled...
BackgroundPost-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/severe COVID-19, led us to determine, an exploratory observational study, whether IDO2 is expressed active PASC, may correlate with pathophysiology.MethodsPlasma or serum, peripheral blood mononuclear cells (PBMC) were obtained from well-characterized PASC...
Human herpesviruses, particularly cytomegalovirus (CMV) and herpes simplex virus (HSV), frequently reactivate in critically ill patients, including those with acute respiratory distress syndrome (ARDS) related to coronavirus disease 2019 (COVID-19). The clinical interpretation of pulmonary herpesvirus reactivation is challenging there ongoing debate about its association mortality benefit antiviral medication. We aimed quantify the incidence pathogenicity CMV HSV reactivations COVID-19 patients.
Cachexia is a multifactorial syndrome, associated with poor survival in patients cancer, and influenced by the gut microbiota. We investigated effects of fecal microbiota transplantation (FMT) on cachexia treatment response advanced gastroesophageal cancer.In double-blind randomized placebo-controlled trial performed Amsterdam University Medical Center, we assigned 24 cachectic metastatic HER2-negative cancer to either allogenic FMT (healthy obese donor) or autologous FMT, prior palliative...
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial these The biological substrate behind observations is unknown. aim of this study was to obtain insight into the association between ageing, host response and patients with COVID-19. Methods We determined 43 biomarkers reflective alterations four pathophysiological domains: endothelial cell coagulation activation, inflammation organ...
Joint bleeding in hemophilia may eventually lead to joint damage. In nonsevere hemophilia, bleeds occur infrequently. Currently, knowledge on the status of patients with using objective imaging is limited.To investigate A.This cross-sectional study included A aged 24-55 years. was assessed by magnetic resonance (MRI) elbows, knees, and ankles International Prophylaxis Study Group (IPSG) scores were calculated. Lifetime history collected from medical files. The contribution factors outcome...
Background The majority of sports‐related injuries involve skeletal muscle. Unlike acute trauma, which is often caused by a single traumatic event leading to symptoms, exercise‐induced microtrauma may remain subclinical and difficult detect. Therefore, novel methods detect localize muscle are desirable. Purpose To assess delayed microstructural changes in upper leg muscles with multiparametric quantitative MRI after running marathon. Study Type Longitudinal; 1‐week prior, 24–48 hours...
To compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation juvenile idiopathic arthritis (JIA).Regions of interest (ROI) were drawn the synovium JIA patients on T1 DCE T2 DWI, followed by extraction maximum enhancement (ME), initial slope (MIS), time to peak (TTP), % different intensity curve shapes (TIC) apparent diffusion coefficient (ADC) ROIs. Mann-Whitney-U test was used for comparing parameters between MRI-active -inactive...
Background Diffusion-weighted imaging (DWI) can depict the inflamed synovial membrane in arthritis. Purpose To study diagnostic accuracy of DWI for detection arthritis compared with clinical reference standard and to compare contrast material-enhanced MRI inflammation. Materials Methods In this institutional review board-approved prospective study, 45 participants juvenile idiopathic (JIA) or suspected having JIA (seven boys, 38 girls; median age, 14 years [interquartile range, 12-16 years])...
Detecting SARS-CoV-2 antibodies may help to diagnose COVID-19. Head-to-head validation of different types immunoassays in well-characterized cohorts hospitalized patients remains needed.We validated three chemiluminescence (CLIAs) (Liaison, Elecsys, and Abbott) one single molecule array assay (SIMOA) (Quanterix) for automated analyzers, rapid immunoassay RIA (AllTest), ELISA (Wantai) parallel first samples from 126 PCR confirmed COVID-19 158 pre-COVID-19 patients. Specificity the AllTest was...