A5003221820- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Chronic Myeloid Leukemia Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related gene regulation
- Eosinophilic Disorders and Syndromes
- Maternal and fetal healthcare
- Intracerebral and Subarachnoid Hemorrhage Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Homelessness and Social Issues
University of Amsterdam
2020-2024
Amsterdam University Medical Centers
2020-2024
Emma Kinderziekenhuis
2020-2024
Bayer (United States)
2023
Chiang Mai University
2023
Amsterdam UMC Location University of Amsterdam
2015-2018
Summary Pregnant women with bleeding disorders require specialised peripartum care to prevent postpartum haemorrhage ( PPH ). If third trimester coagulation factor levels are <0.50 IU mL −1 , prophylactic treatment is indicated and administered according international guidelines. However, optimal dose duration unknown may still occur. The aim of this study was investigate the outcome in von Willebrand disease VWD ) or haemophilia carriership treated current practice From period 2002–2011,...
Joint bleeding in hemophilia may eventually lead to joint damage. In nonsevere hemophilia, bleeds occur infrequently. Currently, knowledge on the status of patients with using objective imaging is limited.To investigate A.This cross-sectional study included A aged 24-55 years. was assessed by magnetic resonance (MRI) elbows, knees, and ankles International Prophylaxis Study Group (IPSG) scores were calculated. Lifetime history collected from medical files. The contribution factors outcome...
Detailed information on the onset, frequency, and severity of bleeding in nonsevere hemophilia is limited. We aimed to assess phenotype persons with analyze association between baseline factor VIII/IX (FVIII/IX) levels joint rate. In DYNAMO (Dynamic Interplay Between Bleeding Phenotype Baseline Factor Level Moderate Mild Hemophilia A B) study, an international multicenter cohort, we included males (FVIII/IX, 0.02-0.35 IU/mL) aged 12 55 years. Information age at first treated (joint) bleed,...
Hemophilia A and B are inherited X-linked disorders of hemostasis, associated with an increased bleeding tendency. Patients severe hemophilia have undetectable clotting factor levels experience spontaneous bleeds. In patients nonsevere hemophilia, the 2% to 40% normal bleeds predominantly occur after provocative events such as trauma surgery. Despite this milder phenotype, may suffer from considerable morbidity mortality risk. However, many aspects course disease treatment remain unclear....
Persons with nonsevere hemophilia A (NSHA) experience less frequent joint bleeding than persons severe A, but may still develop damage. Biomarkers of cartilage and synovial remodeling can reflect ongoing pathologic processes that precede or coincide damage on imaging. If so, biomarkers be an important diagnostic tool for in NSHA.To assess the correlation between MRI-detected NSHA.In a cross-sectional study, men NSHA (factor VIII [FVIII], 2-35 IU/dL) were included. Participants underwent...
Abstract Background Intra-articular bleeds in patients with inherited bleeding disorders lead to active synovitis which may progress a chronic state over time. We explored the diagnostic value of color Doppler ultrasound detecting boys disorders. Results Sixty hemophilia and 3 type von Willebrand disease aged 5 18 years (median 12.3 years) were imaged by gray-scale (US) three centers (Beijing, China [ n = 22], Guangzhou, 12] Toronto, Canada 29])) this observational study. Images...
Pharmacokinetic (PK)-guided dosing is used to individualize factor (F)VIII and FIX replacement therapy.
B. To start an early prophylaxis to avoid joint damage should be discussed even in patients with mild hemophilia.
Background: Bone diseases, such as low bone mineral density (BMD) and osteoporosis are emerging concerns in people with hemophilia (PWH).As a consequence, PWH might experience fractures more frequently than the general population.Aims: Our primary aim was to compare incidence of no bleeding disorders.The secondary identify risk factors associated PWH.Methods: This retrospective, case-control, study based on data from Canadian Bleeding Disorders Registry administrative Institute for Clinical...