A5045746265- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemophilia Treatment and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Autoimmune Bullous Skin Diseases
- Clinical practice guidelines implementation
- Physics of Superconductivity and Magnetism
- Cancer-related gene regulation
- Sexual function and dysfunction studies
- Library Collection Development and Digital Resources
- Textile materials and evaluations
- Dietary Effects on Health
- Advanced Condensed Matter Physics
- Geological and Geochemical Analysis
- Comparative and International Law Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetes and associated disorders
- Blood Coagulation and Thrombosis Mechanisms
- Web and Library Services
- Urticaria and Related Conditions
- Health Promotion and Cardiovascular Prevention
- Digital Humanities and Scholarship
Erasmus MC
2011-2018
Erasmus University Rotterdam
2012-2018
Forschungszentrum Jülich
2009
Summary We performed a nation-wide cross-sectional study to evaluate determinants of bleeding symptoms in large unselected cohort adults with von Willebrand disease (VWD). VWD patients were included (n=664), based on lowest historically measured VWF:Ag and VWF:Act levels ≤30 U/dl. Menorrhagia (85%), cutaneous (77%), from minor wounds (77%) oral-cavity (62%) occurred most frequently. Higher age was associated higher score (BS), determined according Tosetto, females. A 10 year increase 0.8...
Summary Pregnant women with bleeding disorders require specialised peripartum care to prevent postpartum haemorrhage ( PPH ). If third trimester coagulation factor levels are <0.50 IU mL −1 , prophylactic treatment is indicated and administered according international guidelines. However, optimal dose duration unknown may still occur. The aim of this study was investigate the outcome in von Willebrand disease VWD ) or haemophilia carriership treated current practice From period 2002–2011,...
The bleeding phenotype of children with von Willebrand disease (VWD) needs to be characterized in detail facilitate diagnosis during childhood and aid the planning assessment treatment strategies. objective was evaluate occurrence, type, severity a large cohort moderate severe VWD. We included 113 (aged 0-16 years) Type 1 (n = 60), 2 44), 3 9) VWD factor (VWF) antigen and/or VWF ristocetin cofactor levels ≤ 30 U/dL from nation-wide cross-sectional study ("Willebrand Netherlands" study)....
Background: Joint bleeds ( JB ) are reported in a minority of patients with von Willebrand disease VWD but may lead to structural joint damage. Prevalence, severity and impact largely unknown. Objectives: The aim this study was assess prevalence, onset, treatment on health‐related quality life HR ‐QoL) integrity moderate severe . Methods: In the Netherlands 804 [von factor VWF activity ≤30U dL −1 ] completed questionnaire occurrence, sites consequences To analyse number, we additionally...
Background In type 1 von Willebrand Disease (VWD) patients, Factor (VWF) levels and bleeding symptoms are highly variable. Recently, the association between genetic variations in STXBP5 STX2 with VWF has been discovered general population. We assessed relationship STX2, levels, phenotype VWD patients. Methods 158 patients diagnosed according to current ISTH guidelines, we genotyped three tagging-SNPs analyzed their VWF:Ag severity of phenotype, as by Tosetto score. Results rs7978987 was...
Summary Desmopressin causes two- to six-fold increase of factor VIII (FVIII) in mild or moderate haemophilia A patients. However, responses are variable and little is known whether this associated with F8 gene mutation. The study objective was assess the relationship between mutation desmopressin response (absolute relative) determined 97 hemophilia Four amino acid changes (Arg2169His, Pro149Arg, Asn637Ser, Arg612Cys) a number other mutations leading an aberrant FVIII protein deficiency were...
The spin correlations in a series of cobaltate polycrystalline samples with Swedenborgite structure, ABaCo3BO7 (A = Y, Ca, and B Co, Fe, Al, Zn), were studied by means diffuse polarized neutron scattering. alternate stacking kagome triangular Co layers forms tetrahedral Co-network geometrical frustration antiferromagnetically (AF) coupled spins, which typically suppresses long-range order even at low temperatures (~1K) despite Curie-Weiss the 1000 K. generic magnetic scattering as found...
Abstract Inhibition of von Willebrand factor (VWF) expression in endothelial cells results enhanced, possible dysfunctional angiogenesis, consistent with observations severe gastrointestinal bleedings caused by vascular malformations patients disease (VWD). VWF is stored Weibel–Palade bodies (WPB) several other mediators like angiopoietin-2, osteoprotegerin and galectin-3. Increased release angiopoietin-2 has been observed medium lacking VWF, but data on circulating levels angiogenic factors...
To explore key factors for successful support in women with moderate or severe Von Willebrand disease (VWD) who are faced heavy menstrual bleeding (HMB) and surgery.A qualitative study design focus-group interviews thematic analysis of the discussions.Eleven VWD aged 41-68 years (median age 58 years) had a hysterectomy bipolar radiofrequency ablation (BRA) because HMB participated this study. Three 11 participants diagnosed before surgery. Two focus groups were conducted summer 2012....
Adsorption and desorption studies were done of polyhexamethylene biguanide (PHMB) onto two different types textile fiber surfaces. Based on these mathematical modelling, the rate constants calculated. Two experimental conditions used to simulate laundering, namely wet-to-wet dry-to-wet. The model PHMB surface concentrations showed that can be describe adsorption kinetics cotton cotton-polyester blends with reasonable accuracy.