A5023273329- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Sports injuries and prevention
- Cardiac Arrest and Resuscitation
- Advanced Glycation End Products research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Health and Mental Health
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Respiratory Support and Mechanisms
- Cardiac electrophysiology and arrhythmias
- High Altitude and Hypoxia
- Advanced Neuroimaging Techniques and Applications
- Exercise and Physiological Responses
- Mechanical Circulatory Support Devices
- Physical Activity and Health
- Cardiac tumors and thrombi
- Cardiovascular Syncope and Autonomic Disorders
- IL-33, ST2, and ILC Pathways
- Stroke Rehabilitation and Recovery
Radboud University Medical Center
2016-2024
Radboud University Nijmegen
2014-2024
Radboud Institute for Molecular Life Sciences
2021-2024
University Medical Center
2018-2023
Netherlands Heart Institute
2017
Meander Medisch Centrum
2017
University Medical Center Groningen
2017
Hartford Hospital
2017
Liverpool John Moores University
2017
University Medical Center Utrecht
2017
Background: Higher levels of physical activity are associated with a lower risk cardiovascular events. Nevertheless, there is debate on the dose-response relationship exercise and disease outcomes whether high volumes may accelerate coronary atherosclerosis. We aimed to determine between lifelong Methods: Middle-aged men engaged in competitive or recreational leisure sports underwent noncontrast contrast-enhanced computed tomography scan assess artery calcification (CAC) plaque...
Physical activity and exercise training are associated with a lower risk for coronary events. However, cross-sectional studies in middle-aged older male athletes revealed increased artery calcification (CAC) atherosclerotic plaques, which were related to the amount intensity of lifelong exercise. We examined longitudinal relationship between characteristics atherosclerosis. Middle-aged men from MARC-1 (Measuring Athlete's Risk Cardiovascular Events 1) study invited follow-up MARC-2 2) study....
Blood concentrations of cardiac troponin above the 99th percentile are a key criterion for diagnosis acute myocardial injury and infarction. Troponin concentrations, even below percentile, predict adverse outcomes in patients general population. Elevated commonly observed after endurance exercise, but clinical significance this increase is unknown. We examined association between postexercise I long-distance walkers. measured 725 participants (61 [54-69] yrs) before immediately 30 to 55 km...
Cardiac troponins (cTn) are proteins that regulate cardiomyocyte contraction. A rise and fall of cTn above the upper reference limit is diagnostic myocardial injury. Therefore, measurements part routine workup when suspecting acute coronary syndromes. Exercise can also produce elevations. Many studies in last three decades have advanced our understanding exercise-induced release. Beyond technical improvements assays, various predictors release been identified, whereas insight into patterns...
Cerebral blood flow (CBF) is stably maintained through the combined effects of pressure (BP) regulation and cerebral autoregulation. Previous studies suggest that aerobic exercise training improves cardiac baroreflex function beneficially affects BP regulation, but may negatively affect The purpose this study was to reveal impact lifelong on dynamic autoregulation (CA) in older adults. Eleven Masters athletes (MA) (8 men, 3 women; mean age 73 ± 6 yr; >15 yr) 12 healthy sedentary elderly (SE)...
Background The majority of sports‐related injuries involve skeletal muscle. Unlike acute trauma, which is often caused by a single traumatic event leading to symptoms, exercise‐induced microtrauma may remain subclinical and difficult detect. Therefore, novel methods detect localize muscle are desirable. Purpose To assess delayed microstructural changes in upper leg muscles with multiparametric quantitative MRI after running marathon. Study Type Longitudinal; 1‐week prior, 24–48 hours...
ABSTRACT Aims Middle-aged and older male athletes have more coronary atherosclerosis than less active peers. We aimed to explore mechanisms that can contribute this accelerated by comparing exercise-induced changes in hemodynamic factors, circulating hormones, electrolytes, inflammatory markers across with without atherosclerosis. Methods 59 recruited from the MARC-2 study were stratified as controls (coronary artery calcium score (CACS) = 0, n 20), high CACS (≥300 Agatston Units or ≥ 75th...
The magnitude of exercise-induced cardiac troponin (cTn) elevations is dependent on cardiovascular health status, and previous studies have shown that occult coronary atherosclerosis highly prevalent among amateur athletes. We tested the hypothesis middle-aged older athletes with demonstrate greater cTn following a controlled endurance exercise test compared healthy peers. included 59 male from Measuring Athletes' Risk Cardiovascular events 2 (MARC-2) study stratified them as controls...
ABSTRACT Purpose Previous studies have suggested that extreme endurance exercise may induce cardiac microdamage could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a biomarker for assessment fibrosis, inflammation, and strain. We evaluated baseline exercise-induced sST2 concentrations in heterogeneous cohort marathon runners identify predictors concentrations. Methods Ninety-two supplied demographic data, health status, physical activity levels,...
ABSTRACT Purpose Hypertrophic cardiomyopathy (HCM) is characterized by inappropriate left ventricular (LV) wall thickness. Adaptations to exercise can occasionally mimic certain HCM characteristics. However, it unclear whether physical activity affects genotype expression and disease Consequently, we compared lifelong volumes between gene carriers with without phenotype, characteristics among tertiles of in phenotypic patients. Methods We enrolled n = 22 positive/phenotype negative (G+/P−)...
Prolonged exercise can induce cardiac troponin release. As single bouts of may protect against injury, we explored the hypothesis that magnitude exercise-induced release attenuates upon successive days exercise. We also examined whether effects differ between healthy participants and individuals with cardiovascular risk factors (CVRFs) established disease (CVD). I (cTnI) concentrations from whole venous blood samples collected antecubital vein (10 mL) in 383 (61 ± 14 yr) at rest immediately...