Joppe W. Hovius
A5002876648- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Dermatological diseases and infestations
- COVID-19 Clinical Research Studies
- Insect and Pesticide Research
- SARS-CoV-2 and COVID-19 Research
- Toxin Mechanisms and Immunotoxins
- HIV/AIDS Research and Interventions
- Insect symbiosis and bacterial influences
- Zoonotic diseases and public health
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Yersinia bacterium, plague, ectoparasites research
- Long-Term Effects of COVID-19
- Complement system in diseases
- HIV Research and Treatment
- Hepatitis C virus research
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Burkholderia infections and melioidosis
- HIV, Drug Use, Sexual Risk
Amsterdam University Medical Centers
2019-2025
Amsterdam UMC Location University of Amsterdam
2015-2024
University of Amsterdam
2015-2024
Geneeskundige en Gezondheidsdienst
2020-2024
GGD Amsterdam
2023
Corona (Poland)
2021
Inserm
2021
European Society of Clinical Microbiology and Infectious Diseases
2021
Public Health Service of Amsterdam
2021
OLVG
2019-2020
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential IgG function, shows variable composition in humans. Afucosylated variants already used anticancer therapeutic their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated (approximately 6% of total humans) specifically formed enveloped viruses but generally not other antigens. This mediates...
BackgroundMortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight pathways associated unfavourable outcome may lead to new treatment strategies.MethodsWe performed a prospective cohort study of COVID-19 admitted general ward or ICU who underwent serial blood sampling. To provide insight involved disease progression, associations were estimated between risk and measurements 64 biomarkers potential important infection (inflammation,...
Ixodes ticks are major vectors for human pathogens, such as Borrelia burgdorferi, the causative agent of Lyme disease. Tick saliva contains immunosuppressive molecules that facilitate tick feeding and B. burgdorferi infection. We here demonstrate, to our knowledge first time, scapularis salivary protein Salp15 inhibits adaptive immune responses by suppressing dendritic cell (DC) functions. both Toll-like receptor- burgdorferi–induced production pro-inflammatory cytokines DCs DC-induced T...
Lyme borreliosis is the most common tick-borne human disease and caused by Borrelia burgdorferi sensu lato (s.l.). miyamotoi, a relapsing fever spirochaete, transmitted transovarially, whereas this has not been shown for B. (s.l). Therefore, (s.l) considered to cycle from nymphs larvae through vertebrates. Larvae of Ixodes ricinus are occasionally infected, but their vector competence never studied. We challenged 20 laboratory mice with field-collected I. ricinus. A subset these was analysed...
Abstract The Lyme disease agent, Borrelia burgdorferi , colonizes the gut of tick Ixodes scapularis which transmits pathogen to vertebrate hosts including humans. Here we show that B . colonization increases expression several genes pixr encoding a secreted protein with Reeler domain. RNA interference-mediated silencing or immunity against PIXR in mice, impairs ability colonize gut. inhibits bacterial biofilm formation vitro and vivo. Abrogation function vivo results alterations microbiome,...
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections often cause only mild disease that may evoke relatively low Ab titers compared with patients admitted to hospitals. Generally, total bridging assays combine good sensitivity high specificity. Therefore, we developed sensitive for detection of SARS-CoV-2 Abs the receptor-binding domain (RBD) and nucleocapsid protein in addition conventional isotype-specific assays. kinetics was assessed PCR-confirmed, hospitalized...
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this had 0.54 to 0.74 log 10 increase (i.e., ~3.5-fold 5.5-fold increase) viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 other strains. Without treatment, advanced HIV—CD4 counts below 350 cells per cubic millimeter, long-term clinical consequences—is expected be reached, on average, 9 months after diagnosis for their thirties variant. Age, sex,...
Concerns about long-lasting symptoms attributed to Lyme borreliosis (LB) are widespread in the Western world, while such highly prevalent general population.In largest prospective study date, adults with physician-confirmed LB were included at start of antibiotic treatment. Primary outcomes, prevalence persistent and symptom severity, assessed using three-monthly standardised questionnaires during one year. Persistent defined as impaired scores for fatigue (CIS, subscale fatigue), cognitive...
Rationale: Bacterial lung microbiota are correlated with inflammation and acute respiratory distress syndrome (ARDS) altered in severe coronavirus disease (COVID-19). However, the association between (including fungi) resolution of ARDS COVID-19 remains unclear. We hypothesized that increased bacterial fungal burdens related to nonresolving mortality COVID-19. Objectives: To determine relation clinical outcomes COVID-19–related ARDS. Methods: This observational cohort study enrolled...
BackgroundPost-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/severe COVID-19, led us to determine, an exploratory observational study, whether IDO2 is expressed active PASC, may correlate with pathophysiology.MethodsPlasma or serum, peripheral blood mononuclear cells (PBMC) were obtained from well-characterized PASC...
Human herpesviruses, particularly cytomegalovirus (CMV) and herpes simplex virus (HSV), frequently reactivate in critically ill patients, including those with acute respiratory distress syndrome (ARDS) related to coronavirus disease 2019 (COVID-19). The clinical interpretation of pulmonary herpesvirus reactivation is challenging there ongoing debate about its association mortality benefit antiviral medication. We aimed quantify the incidence pathogenicity CMV HSV reactivations COVID-19 patients.