A5091240947- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- Blood donation and transfusion practices
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Parvovirus B19 Infection Studies
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Vector-borne infectious diseases
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Full-Duplex Wireless Communications
- Dermatological and COVID-19 studies
- Polyomavirus and related diseases
- Respiratory viral infections research
- Blood groups and transfusion
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
Sanquin
2016-2025
University of Amsterdam
2012-2025
Amsterdam University Medical Centers
2019-2025
Amsterdam UMC Location University of Amsterdam
2012-2023
National Institute for Public Health and the Environment
2011-2020
University of Saskatchewan
2013
Czech Academy of Sciences, Institute of Microbiology
2013
Technical University of Munich
2013
National Taiwan University Hospital
2013
Asklepios Klinik St. Georg
2013
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential IgG function, shows variable composition in humans. Afucosylated variants already used anticancer therapeutic their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated (approximately 6% of total humans) specifically formed enveloped viruses but generally not other antigens. This mediates...
Parvovirus B19V (B19V) infection during pregnancy can be complicated by potentially life-threatening fetal hydrops, which managed intrauterine transfusion (IUT). This study investigates the long-term temporal patterns in epidemiology of and evaluates impact on combining data infections from Dutch Sentinel Surveillance system period 1990 to 2023, blood banking hospital hydrops. Using wavelet analysis, we identified annual epidemic cycles Netherlands 1990-2019 superimposed multiannual...
In Europe, the dynamics of endemic hepatitis E virus (HEV) infection remain enigmatic. We studied presence silent HEV among Dutch blood donors. Using donations collected throughout Netherlands in 2011 and 2012, 40,176 were tested for RNA 459 pools 48 or 480 donations. Deconstruction reactive identified 13 viraemic addition, 5,239 donors anti-HEV IgG IgM when IgM-positive. Of donations, 1,401 (27%) repeat-positive IgG, which 49 (3.5%) also positive IgM. Four IgM-positive RNA. seroprevalence...
In 2004, the novel respiratory human coronavirus NL63 (HCoV-NL63) was identified, and subsequent research revealed that virus has spread worldwide. HCoV-229E is a close relative of HCoV-NL63, infection with either can lead to hospitalization young children, immunocompromised persons, elderly. Children infected HCoV-NL63 often develop croup, obstruction airway. this study we investigated at which age children are confronted for first time an and, thus, they seroconvert positivity. We designed...
The public health implications of hepatitis E virus (HEV) in Europe have changed due to increasing numbers cases and recent reports chronic, persistent HEV infections associated with progression cirrhosis immunosuppressed patients. main infectious risk for such patients is exposure undercooked infected pork products blood transfusion. We summarised the epidemiology among donors also outlined any strategies prevent transfusion-transmitted HEV, 11 European countries. In response threat posed...
Background. Treatment of patients with chronic hepatitis B (CHB) nucleos(t)ide analogues (NAs) suppresses virus (HBV) DNA production but does not affect the synthesis RNA pregenome or HBV messenger RNA. Whether RNA–containing particles continue to be secreted into bloodstream remains controversial.
BACKGROUND The incidence of hepatitis E virus (HEV) infection in the Netherlands is high. Blood donors are not routinely screened for HEV infection, but since January 2013, donations used production solvent/detergent (S/D)‐treated plasma have been RNA. STUDY DESIGN AND METHODS Donations were RNA pools 96 and 192 donations. In addition, all made between 60 days before after each RNA‐positive donation tested individually anti‐HEV immunoglobulin G. RESULTS screening 59,474 2013 December 2014...
The polyomavirus family currently includes thirteen human (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis nephropathy (BKPyV), Merkel cell carcinoma (MCPyV), trichodysplasia spinulosa (TSPyV). Some recently discovered polyomaviruses of still unknown prevalence pathogenic potential. Because infections persist might be transferred by blood components patients, we studied...
The world is combating an ongoing COVID-19 pandemic with health-care systems, society and economies impacted in unprecedented way. It unclear how many people have contracted the causative coronavirus (SARS-CoV-2) unknowingly are asymptomatic. Therefore, reported cases do not reflect true scale of outbreak. Here we present prevalence distribution antibodies to SARS-CoV-2 a healthy adult population Netherlands, which highly affected country, using high-performance immunoassay. Our results...
In October 2020, the first case of autochthonous West Nile virus neuroinvasive disease was diagnosed in Netherlands with a presumed infection last week August. Investigations revealed five more cases local (WNV) infection. The resided region where WNV detected bird and mosquitoes August 2020. Molecular analysis successful for two identified presence lineage 2.
Characterisation of the human antibody response to SARS-CoV-2 infection is vital for serosurveillance purposes and treatment options such as transfusion with convalescent plasma or immunoglobulin products derived from plasma. In this study, we longitudinally quantitatively analysed responses in RT-PCR-positive adults during first 250 days after onset symptoms.
Teclistamab and other B-cell maturation antigen (BCMA)-targeting bispecific antibodies (BsAbs) have substantial activity in patients with heavily pretreated multiple myeloma (MM) but are associated a high rate of infections. BCMA is also expressed on normal plasma cells mature B cells, which essential for the generation humoral immune response. The aim this study was to improve understanding impact BCMA-targeting BsAbs immunity. teclistamab polyclonal immunoglobulins cell counts evaluated MM...
Background Since 2009, European guidelines recommend individuals with hepatitis B virus (HBV) and HIV be tested for D (HDV). Aim To analyse HDV testing in HBV/HIV during routine practice the Netherlands. Methods We assessed data from ATHENA cohort of people who were ever HBV surface antigen-positive, aged ≥ 18 years attended one 24 treatment centres Netherlands 2000–22. Using longitudinal analysis, we estimated percentage (antibody or RNA test) over time. In cross-sectional determinants...
11Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University Amsterdam, The Netherlands, 2Department ofNeurology, 3Department Intensive Care, ofAmsterdam, 4Department Clinical Virology, Netherlands,5Department Erasmus Centre, Rotterdam, 6Department Radiology, Amsterdam,Amsterdam, 7Department Pathology, 8Centre Expertise forRabies, Canadian Food Inspection Agency, Ottawa Laboratory (Fallowfield), Ottawa, Ontario, Canada
Background. Recent outbreaks in the Netherlands allowed for laboratory follow-up of a large series patients with acute Q fever and evaluation test algorithms to detect chronic fever, condition considerable morbidity mortality. Methods. For 686 IgG antibodies Coxiella burnetii were determined using an immunofluorescence assay at 3, 6, 12 months follow-up. Polymerase chain reaction (PCR) was performed after on earlier serum samples phase I antibody titer ≥1:1024. Results. In 43% patients, II...
BACKGROUND: In 2007, 2008, and 2009 outbreaks of Q‐fever occurred in the Netherlands with increasing magnitude. The outbreak 2354 reported cases is largest human ever recorded. To assess extent infection safety donated blood, we tested local blood donations for presence Coxiella burnetii antibodies DNA. STUDY DESIGN AND METHODS: Starting May 2009, more than 40,000 serum samples were collected from all consenting donors areas high incidence. 1004 highest number C. DNA by polymerase chain...
Background Recent studies show that endemic hepatitis E virus ( HEV ) infection occurs frequently in some developed countries. In the N etherlands 2013, routine screening of 35,220 plasma donations for RNA showed 20 donors to be viremic (1:1761), which seems contradict reports declining seroprevalence recent past. Study Design and Methods To asses pressure changes over time, archived samples from D utch blood collected 1988 2000 were tested anti‐ immunoglobulin Ig G . The findings compared...
Background In this study, we aimed to identify baseline predictors of response in chronic hepatitis B patients treated with a combination pegylated interferon (PEG-IFN)-α2a and adefovir. Methods We 92 (44 e antigen [HBeAg]-positive 48 HBeAg-negative) HBV DNA>100,000 copies/ml (>17,182 IU/ ml) PEG-IFN adefovir for weeks followed them up 2 years. Baseline markers HBeAg loss, combined (HBeAg negativity, DNA levels ≤2,000 IU/ml alanine aminotransferase [ALT] normalization) surface (HBsAg)...
BACKGROUND The increasing incidence of reported hepatitis E cases in Europe has focused attention on virus (HEV) and the risk transfusion‐transmitted E. aim this study was to investigate prevalence antibodies HEV (anti‐HEV) among Danish blood donors 2013 compare it previous studies Denmark. In addition we wanted relative reactivity two different assays. STUDY DESIGN AND METHODS Samples from 504 were collected analyzed for anti‐HEV with an in‐house assay developed at National Institutes...
The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide hepatitis C virus (HCV) treatment uptake among patients coinfected with human immunodeficiency (HIV) and HCV.Data were obtained from ATHENA HIV observational cohort in which >98% of HIV-infected ever registered 1998 are included. Patients included if they had 1 positive HCV RNA result, did not have spontaneous clearance, known still be care. Treatment outcome...
Abstract The world is combating an ongoing COVID-19 pandemic 1-4 . Health-care systems, society and the economy are impacted in unprecedented way. It unclear how many people have contracted causative coronavirus (SARS-CoV-2) unknowingly. Therefore, reported cases do not reflect true scale of outbreak 5-9 Natural herd immunity has been suggested as a potential exit strategy during outbreaks, which may arise when 50-67% community infected 10 Here we present prevalence distribution antibodies...