A5009731605- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Bacterial Infections and Vaccines
- Cytomegalovirus and herpesvirus research
- Complement system in diseases
- Peripheral Neuropathies and Disorders
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- IgG4-Related and Inflammatory Diseases
- Multiple Sclerosis Research Studies
- Blood groups and transfusion
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- Blood transfusion and management
- Platelet Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- vaccines and immunoinformatics approaches
University of Amsterdam
2016-2025
Sanquin
2016-2025
Amsterdam University Medical Centers
2018-2025
University of Miami
2025
Amsterdam UMC Location University of Amsterdam
2013-2024
Netherlands Institute for Neuroscience
2019-2024
Vrije Universiteit Amsterdam
2019-2022
Amsterdam Neuroscience
2022
Peter Doherty Institute
2022
The University of Melbourne
2022
Adipose tissue contains a stromal vascular fraction (SVF) that is rich source of adipose tissue-derived stem cells (ASCs). ASCs are multipotent and in vitro-expanded have the capacity to differentiate, into amongst others, adipocytes, chondrocytes, osteoblasts, myocytes. For engineering purposes, however, it would be advantageous use whole SVF, which can transplanted without further vitro selection or expansion steps. Because little known about freshly isolated we phenotypically...
Data are scarce on immunogenicity of COVID-19 vaccines in patients with autoimmune diseases, who often treated immunosuppressive drugs. We aimed to investigate the effect different drugs antibody development after vaccination diseases.In this study, we used serum samples collected from diseases and healthy controls were included two ongoing prospective cohort studies Netherlands. Participants eligible for inclusion substudy if they had been vaccinated any vaccine via Dutch national...
<h3>Objectives</h3> Millions of patients worldwide are treated with therapeutic monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss response. Fully human agents, such as the anti-tumour necrosis factor α (anti-TNFα) adalimumab, considered weakly but anti-adalimumab antibodies (AAA) were recently detected more than half rheumatoid arthritis (RA) within 28 weeks treatment. A study was undertaken determine...
CD8+ T cells play a critical role in the immune response to viral pathogens. Persistent human cytomegalovirus (HCMV) infection results strong increase number of virus-specific, quiescent effector-type with constitutive cytolytic activity, but molecular pathways involved induction and maintenance these are unknown. We show here that HCMV induced acute lasting changes transcriptomes virus-reactive collected from HCMV-seropositive patients at distinct stages infection. Enhanced cell cycle...
A hallmark of B-cell immunity is the generation a diverse repertoire antibodies from limited set germline V(D)J genes. This usually defined in terms amino acid composition. However, variable domains may also acquire N-linked glycans, process conditional on introduction consensus motifs (N-glycosylation sites) during somatic hypermutation. High levels domain glycans have been associated with autoantibodies rheumatoid arthritis, as well certain follicular lymphomas. role these humoral immune...
The socioeconomic burden of COVID-19 and pressure on health-care systems can only be reduced by achieving herd immunity against SARS-CoV-2. For to achieved, it has been estimated that, depending the efficacy vaccines employed, approximately 60–100% global population needs vaccinated.1Anderson RM Vegvari C Truscott J Collyer BS Challenges in creating SARS-CoV-2 infection mass vaccination.Lancet. 2020; 396: 1614-1616Summary Full Text PDF PubMed Scopus (386) Google Scholar Countries all over...
Based on the advances in treatment of multiple sclerosis (MS), currently available disease-modifying treatments (DMT) have positively influenced disease course MS. However, efficacy DMT is highly variable and increasing comes with a more severe risk profile. Hence, unmet need for safer selective remains. Specifically restoring immune tolerance towards myelin antigens may provide an attractive alternative. In this respect, antigen-specific tolerisation autologous tolerogenic dendritic cells...
Existing literature suggests that patients with autoimmune diseases might be at increased risk of developing severe COVID-19,1Gianfrancesco M Hyrich KL Al-Adely S et al.Characteristics associated hospitalisation for COVID-19 in people rheumatic disease: data from the Global Rheumatology Alliance physician-reported registry.Ann Rheum Dis. 2020; 79: 859-866Crossref PubMed Scopus (911) Google Scholar which emphasises importance vaccination against SARS-CoV-2 this patient group. However, vaccine...
Characterisation of the human antibody response to SARS-CoV-2 infection is vital for serosurveillance purposes and treatment options such as transfusion with convalescent plasma or immunoglobulin products derived from plasma. In this study, we longitudinally quantitatively analysed responses in RT-PCR-positive adults during first 250 days after onset symptoms.
The mechanisms preventing detrimental T-cell responses against commensal skin bacteria remain elusive. Using monocyte-derived and skin-derived dendritic cells (DCs), we demonstrate that epidermal Langerhans (LCs), the DCs in most superficial layer of skin, have a poor capacity to internalize because low expression FcγRIIa. Furthermore, LCs show deficiency processing major histocompatibility complex II (MHC-II)-restricted presentation bacterial antigens, as result decreased molecules involved...
Objective Results from anti‐CD20 therapies demonstrate that B‐ and T‐cell interaction is a major driver of multiple sclerosis (MS). The local presence B‐cell follicle‐like structures oligoclonal bands in MS patients indicates certain B cells infiltrate the central nervous system (CNS) to mediate pathology. Which peripheral triggers underlie development CNS‐infiltrating not fully understood. Methods Ex vivo flow cytometry was used assess chemokine receptor profiles blood, cerebrospinal fluid,...
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