A5087783176- Blood donation and transfusion practices
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- Liver Disease and Transplantation
- Vector-borne infectious diseases
- Organ Donation and Transplantation
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
- HIV/AIDS Research and Interventions
- Platelet Disorders and Treatments
- Surgical site infection prevention
- Veterinary medicine and infectious diseases
- Vaccine Coverage and Hesitancy
- Proteoglycans and glycosaminoglycans research
- Sex work and related issues
- Glutathione Transferases and Polymorphisms
Sanquin
2014-2024
Academic Medical Center
2011-2014
Loyola University Medical Center
2012
Jeroen Bosch Ziekenhuis
2011
University of Twente
2011
St. Antonius Ziekenhuis
2011
National Institute for Public Health and the Environment
2011
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of current disease 2019 (COVID‐19) pandemic. Understanding immune response that provides specific immunity but may also lead to immunopathology crucial for design potential preventive and therapeutic strategies. Here, we characterized quantified SARS‐CoV‐2‐specific responses in patients with different clinical courses. Compared individuals a mild presentation, CD4 + T‐cell were qualitatively impaired...
In Europe, the dynamics of endemic hepatitis E virus (HEV) infection remain enigmatic. We studied presence silent HEV among Dutch blood donors. Using donations collected throughout Netherlands in 2011 and 2012, 40,176 were tested for RNA 459 pools 48 or 480 donations. Deconstruction reactive identified 13 viraemic addition, 5,239 donors anti-HEV IgG IgM when IgM-positive. Of donations, 1,401 (27%) repeat-positive IgG, which 49 (3.5%) also positive IgM. Four IgM-positive RNA. seroprevalence...
The world is combating an ongoing COVID-19 pandemic with health-care systems, society and economies impacted in unprecedented way. It unclear how many people have contracted the causative coronavirus (SARS-CoV-2) unknowingly are asymptomatic. Therefore, reported cases do not reflect true scale of outbreak. Here we present prevalence distribution antibodies to SARS-CoV-2 a healthy adult population Netherlands, which highly affected country, using high-performance immunoassay. Our results...
BACKGROUND: In 2007, 2008, and 2009 outbreaks of Q‐fever occurred in the Netherlands with increasing magnitude. The outbreak 2354 reported cases is largest human ever recorded. To assess extent infection safety donated blood, we tested local blood donations for presence Coxiella burnetii antibodies DNA. STUDY DESIGN AND METHODS: Starting May 2009, more than 40,000 serum samples were collected from all consenting donors areas high incidence. 1004 highest number C. DNA by polymerase chain...
Background Recent studies show that endemic hepatitis E virus ( HEV ) infection occurs frequently in some developed countries. In the N etherlands 2013, routine screening of 35,220 plasma donations for RNA showed 20 donors to be viremic (1:1761), which seems contradict reports declining seroprevalence recent past. Study Design and Methods To asses pressure changes over time, archived samples from D utch blood collected 1988 2000 were tested anti‐ immunoglobulin Ig G . The findings compared...
Abstract The world is combating an ongoing COVID-19 pandemic 1-4 . Health-care systems, society and the economy are impacted in unprecedented way. It unclear how many people have contracted causative coronavirus (SARS-CoV-2) unknowingly. Therefore, reported cases do not reflect true scale of outbreak 5-9 Natural herd immunity has been suggested as a potential exit strategy during outbreaks, which may arise when 50-67% community infected 10 Here we present prevalence distribution antibodies...
BACKGROUND The screening of Dutch blood donations for West Nile virus (WNV) may be imminent, as WNV emerges in nearby countries and more donors travel to WNV‐affected regions. Since 2016 the related, mosquito‐borne Usutu (USUV) causes seasonal mortality birds. To what extent will human USUV infections affect donor screening? STUDY DESIGN AND METHODS From April through September 2018, plasma samples from blackbird‐rich regions were stored. When increased bird was reported August, July, tested...
Risk behavior-based donor selection procedures are widely used to mitigate the risk of transfusion-transmissible infections (TTIs), but their effectiveness is disputed in countries with low residual risks TTIs.In 1995 2014, Dutch blood donors infected hepatitis B virus (HBV), C (HCV), human immunodeficiency (HIV), T-lymphotropic (HTLV), or syphilis were interviewed by trained medical counselors identify factors associated TTIs. Trends prevalence and incidence TTIs analyzed using binomial...
The incidence of autochthonous hepatitis E virus genotype 3 (HEV gt3) infections in Western Europe is high. Although pigs are a major reservoir the virus, exact sources and transmission route(s) HEV gt3 to humans remain unclear.To determine role meat consumption at population level, seroprevalence anti-HEV IgG antibodies was compared between Dutch blood donors with vegetarian lifestyle who consume on daily basis.The age-weighted among not eating significantly lower than meat-eating (12.4% vs...
The incidence of transfusion-transmitted malaria is very low in non-endemic countries due to strict donor selection. optimal strategy mitigate the risk without unnecessary exclusion blood donations is, however, still debated and asymptomatic carriers Plasmodium species may be qualified donate for transfusion purposes. In April 2011, a 59-year-old Dutch woman with spiking fevers four days was diagnosed malariae infection. patient had never been abroad, but nine weeks before, she received red...
Heparan sulfate proteoglycans (HSPGs) are well known for their proposed role in glomerular filtration. In addition, HSPGs can bind the leukocyte adhesion molecule l-selectin and chemokines, suggesting a inflammation. We examined panel of biopsies representing different human primary kidney diseases monocyte chemoattractant protein-1 (MCP-1) binding. various renal diseases, MCP-1 binding to interstitial perivascular matrix is increased, which significantly associated with influx. proteinuric...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of current disease 2019 (COVID-19) pandemic. Understanding both immunological processes providing specific immunity and potential immunopathology underlying pathogenesis this may provide valuable insights for therapeutic interventions. Here, we quantified SARS-CoV-2 immune responses in patients with different clinical courses. Compared to individuals a mild presentation, CD4+ T cell were...
Abstract Background Less discriminatory donor selection policies for men who have sex with (MSM) may impact transfusion safety in terms of higher residual risks known transfusion‐transmitted infections (TTIs), increased vulnerability toward new TTIs that are also transmitted via sex, and HIV masked by pre‐exposure prophylaxis (PrEP). Study Design Methods TTI trends Dutch donors were studied over a 13‐year period (2011–2023), characterized successive relaxations MSM deferral criteria....
Blood donations resulting in "nontransparent turbid milky" plasma must be discarded. The aim of this study was to objectively determine opacity and identify risk factors for donations.This case-control included 238 whole blood donors who provided (cases) 309 random control subjects with normal plasma. Participants filled a questionnaire regarding cardiovascular factors. Fat intake assessed using validated questionnaire. Opacity lipids were measured. Additional data retrieved from the bank...
Awareness of infection with SARS-CoV-2 is crucial for the effectiveness COVID-19 control measures. Here, we investigate awareness and symptoms in relation to antibodies against healthy plasma donors. We asked individuals donating across Netherlands between May 11th 18th 2020 report COVID-19-related symptoms, tested indicative a past SARS-CoV-2. Among 3,676 antibodies, from questionnaire data, 239 (6.5%) are positive antibodies. Of those, 48% suspect no COVID-19, despite majority reporting...
Deferral of men who have sex with (MSM) from blood donation is highly debated. We therefore investigated their suitability to donate blood.We compared the antibody prevalence 10 sexually and transfusion-transmissible infections (TTIs) among 583 MSM age-matched repeat male donors. were classified as low risk (lr) or medium-to-high (hr) based on self-reported sexual behavior qualified unqualified using Dutch donor deferral criteria. Infection pressure (IP) was defined number antibody-reactive...
Background Blood donors unaware of Trypanosoma cruzi infection may donate infectious blood. Risk factors and the presence T. antibodies in at-risk Dutch blood were studied to assess whether specific safety measures are warranted Netherlands. Methodology Birth a country endemic for Chagas disease (CEC), having mother born CEC, or resided at least six continuous months CEC considered risk infection. From March through September 2013, factor questions asked all who volunteered components. Serum...
BACKGROUND In the Netherlands, needle‐related events (NREs) including tattoos, piercings, and acupuncture are a reason for temporary blood donor deferral. This study aims to evaluate whether donors with recent NREs had higher risk of transfusion‐transmissible infections (TTIs) compared without NREs. STUDY DESIGN AND METHODS Data from 2006 through 2015 on all donation attempts in Netherlands were collected. Multivariate regression models (for repeated measurements) used assess associations...
BACKGROUND: Since 2007, large outbreaks of Q fever occurred in the Netherlands. The unprecedented number infections resulted need for Dutch blood transfusion service to evaluate risk transmission Coxiella burnetii via blood. STUDY DESIGN AND METHODS: A lookback procedure (recipient tracing) was performed transfused products whole donors with confirmed C. infection within 3 weeks before after donation. Repository samples index donations were tested real‐time polymerase chain reaction (PCR)...
Background The N etherlands experienced major Q fever outbreaks from 2007 through 2009. An increasing number of human chronic cases has been reported in the affected area. Blood donors unaware C oxiella burnetii infection might be infectious for transfusion recipients. Local blood donations were screened serologic signs infection. Study Design and Methods From A ugust 2012 J anuary 2013, a total 2490 serum samples collected all consenting most outbreak area P hase II anti‐ immunoglobulin G...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic challenges governments worldwide to balance appropriate virus control measures and their societal economic consequences. These include the identification, isolation testing of potentially infected individuals. As this relies on an individual’s awareness infection, we investigated extent which healthy adults suspected having had COVID-19, how COVID-19 suspicion symptoms relate antibodies indicative a past infection with...
Background and Objectives Individuals may donate blood in order to determine their infection status after exposure an increased risk. Such test‐seeking behaviour decreases transfusion safety. Instances of test seeking are difficult substantiate as donors unlikely admit such behaviour. However, manifestation a population repeat be determined using statistical inference. Materials Methods Test‐seeking would highly motivated following risk, influencing the timing donation. Donation intervals...
Abstract Background and objective Donor selection criteria (DSC) are a vital link in the chain of supply Substances Human Origin (SoHO) but also subject to controversy differences opinion. Traditionally, DSC have been based on application precautionary principle. Materials methods From 2017 2020, TRANSPOSE (TRANSfusion transplantation PrOtection SElection donors), European research project, aimed identify discrepancies between current by proposing standardized risk assessment method for all...