A5069227141- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Clinical Nutrition and Gastroenterology
- Parasitic Diseases Research and Treatment
- Insect symbiosis and bacterial influences
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Nutrition and Health in Aging
- Immunotherapy and Immune Responses
- HIV-related health complications and treatments
- Blood groups and transfusion
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Parasite Biology and Host Interactions
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Esophageal and GI Pathology
- Parasites and Host Interactions
- Antibiotic Resistance in Bacteria
Erasmus MC
2018-2023
Sanquin
2016-2018
University Medical Center Utrecht
1993-2016
Utrecht University
2009-2013
Canisius-Wilhelmina Ziekenhuis
2011
École Normale Supérieure - PSL
2009
University of Amsterdam
1984-2009
Institute of Social and Preventive Medicine
2009
University of Bern
2009
Heidelberg University
1993
In Amsterdam, HIV prevalence has nearly halved among injecting drug users (IDU) since 1990. Hepatitis C virus (HCV) also declined; and HCV incidence dropped to zero. We examined possible explanations for these time trends, which the implementation of harm reduction measures aimed at reducing risk behaviour IDU.We used individual-based modelling spread HCV. Information about demographic parameters was obtained from Amsterdam Cohort Study (ACS) users. The model included changes in inflow new...
Background People who inject drugs (PWID) are disproportionally affected by the hepatitis C virus (HCV) infection. The efficacy of HCV treatment has significantly improved in recent years with introduction direct-acting antivirals (DAAs). However, DAAs more costly than pegylated-interferon and ribavirin (PegIFN/RBV). We aimed to assess cost-effectiveness four strategies among PWID scale-up. Methods An individual-based model was used describing HIV transmission disease progression PWID....
BACKGROUND The incidence of hepatitis E virus (HEV) has increased substantially in Europe recently, thereby threatening blood safety. A cost‐effectiveness analysis for HEV screening donations the Netherlands was performed. STUDY DESIGN AND METHODS simulation model developed to mimic process donation, infections donor population, donation testing, and transmission transfusion recipients. variability viral loads among donors modeled using observed loads. number (incurable) chronic organ stem...
With the 2020 target year for elimination of lymphatic filariasis (LF) approaching, there is an urgent need to assess how long mass drug administration (MDA) programs with annual ivermectin + albendazole (IA) or diethylcarbamazine (DA) would still have be continued, and can accelerated. We addressed this using mathematical modeling.We used 3 structurally different models LF transmission (EPIFIL, LYMFASIM, TRANSFIL) simulate trends in microfilariae (mf) prevalence a range endemic settings,...
ABSTRACT The rapid decay of the viral load after drug treatment in patients infected with human immunodeficiency virus type 1 (HIV-1) has been shown to result from loss cells due their high turnover, a generation time around 2 days. Traditionally, dynamics is investigated using models differential equations which both death rate and production are assumed be constant. Here, we describe age-structured rates depend on age cells. In order investigate effects age-dependent rates, compared these...
Abstract Background and Aims Treatment of injecting drug users (IDU) for hepatitis C virus (HCV) infection may prevent onward transmission. Treating individuals who often share equipment is most likely to new infections. However, these high‐risk IDU are also more become re‐infected than low‐risk IDU. We investigated which group treatment best targeted. Design modelled the expected benefits per one chronically HCV‐infected in a population low‐ The treating or were compared. Measurements...
ObjectivesMethicillin-resistant Staphylococcus aureus (MRSA) infections impose a considerable burden on health systems, yet there is remarkable variation in the global incidence and epidemiology of MRSA. The MACOTRA consortium aimed to identify bacterial markers epidemic success MRSA isolates Europe using representative collection originating from France, Netherlands United Kingdom.MethodsOperational definitions were defined meetings compose balanced strain successful sporadic isolates....
Hepatitis C virus (HCV) and human immunodeficiency (HIV) are both transmitted through populations of injecting drug users (IDU) by the sharing contaminated syringes. Prevalence HCV is high in most IDU populations, whereas HIV prevalence varies considerably across populations. Understanding dynamics these interacting infections may allow us to use as an indicator for risk persistent spread HIV. We developed a mathematical model that describes population. The allows HCV–HIV co-infection...
The objectives of this study were to determine the incidence density and occurrence horizontal spread highly resistant gram-negative rods (HR-GNRs) in Dutch hospitals. factors that influence these outcome measures also investigated.All patients with HR-GNRs, as determined by sample testing, who hospitalized 1 18 hospitals during a 6-month period (April through October 2007) included study. For all available isolates, species was identified, susceptibility (including presence...
Hepatitis E virus (HEV) infections may be acquired through transfusion of blood components. As transfusion-transmitted mostly affect vulnerable individuals, measures to ensure the supply safe components are under discussion. On basis epidemiological situation in Germany, different testing strategy scenarios were investigated simulation studies. Testing for HEV RNA by nucleic acid amplification technique (NAT) assays with a pool size 96, and 95% LoD 20 IU/ml will result an 80% reduction...
Background Stable low pre-control prevalences of helminth infection are not uncommon in field settings, yet it is poorly understood how such levels can be sustained, thereby challenging efforts to model them. Disentangling possible facilitating mechanisms important, since these may differently affect intervention impact. Here we explore the role assortative (i.e. non-homogenous) mixing and exposure heterogeneity transmission, using onchocerciasis as an example. Methodology/Principal findings...
Background The existence of locations with low but stable onchocerciasis prevalence is not well understood. An often suggested yet poorly investigated explanation that the infection spills over from neighbouring higher densities. Methodology We adapted stochastic individual based model ONCHOSIM to enable simulation multiple villages, separate blackfly (intermediate host) and human populations, which are connected through regular movement villagers and/or flies. With this we explore impact...
We aimed to identify temporal trends in all-cause and cause-specific mortality rates among people who use drugs (PWUD) compared with the general Dutch population determine whether differed by hepatitis C virus (HCV)/HIV (co) infection status.Longitudinal cohort study.Using data from Amsterdam Cohort Studies 1254 PWUD (1985-2012), standardized ratios (SMRs) were calculated; SMRs stratified serological group (HCV/HIV-uninfected, HCV-monoinfected, HCV/HIV-coinfected) calendar period. Temporal...
To determine the potential of treatment as prevention for reducing HIV incidence among injecting drug users (IDU).Transmission dynamics influenced by cART uptake and demographic changes were studied using an individual-based model. Parameters based on data Amsterdam Cohort Study, counterfactual scenarios examined this city. Demography modeled population was also varied to allow more general conclusions.We estimated that over complete epidemic IDU in historic use has led only 2% less...
One of the hypothesized functions marine protected areas (MPAs) is to serve as sources biomass, with biomass spilling over from reserve into neighbouring, harvested areas. We argue that net larval flow (from or reserve) depends on between-area differences in population-level production rate, whereas direction adult standing stock. Hence, an important question whether increases (overcompensation) decreases (undercompensation) increased per capita mortality. show a consumer–resource context,...
Background and Objectives Individuals may donate blood in order to determine their infection status after exposure an increased risk. Such test‐seeking behaviour decreases transfusion safety. Instances of test seeking are difficult substantiate as donors unlikely admit such behaviour. However, manifestation a population repeat be determined using statistical inference. Materials Methods Test‐seeking would highly motivated following risk, influencing the timing donation. Donation intervals...
Methicillin resistant Staphylococcus aureus (MRSA) bacteria cause serious, often healthcare-associated infections and are frequently highly to diverse antibiotics. Multiple MRSA clonal complexes (CCs) have evolved independently countries different prevalent CCs. It is unclear when why the dominant CC in a region may switch. We developed mathematical deterministic model of competing for limited resource. The distinguishes 'standard MRSA' multidrug sub-populations within each CC, allowing...
Background Anti-RhD immunised donors provide anti-RhD immunoglobulins used for the prevention of rhesus disease. These are periodically hyper-immunised (boostered) to retain a high titer level anti-RhD. Study design and methods We analysed donor records from 1998 2016, consisting 30,116 titers 755 donors, encompassing 3,372 booster events. Various models were fit these data allow describing over time. Results A random effects model with log-linear decline time saturating response boostering...
Background Dual infection with HIV-1 and HIV-2, which is not uncommon in West Africa, has important implications for transmission, progression, antiretroviral therapy. Few studies have examined HIV viral dynamics this setting. Methods We compared HIV-2 loads from 65 dually infected, therapy-naïve Senegalese subjects. Participants provided demographic information blood, oral fluid, cervicovaginal lavage (CVL) or semen samples virologic immunologic testing. Associations between levels plasma,...