A5089817164- Blood donation and transfusion practices
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Blood transfusion and management
- Hepatitis B Virus Studies
- Iron Metabolism and Disorders
- Hepatitis C virus research
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Healthcare cost, quality, practices
- Hemophilia Treatment and Research
- Viral Infections and Outbreaks Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- COVID-19 epidemiological studies
- Malaria Research and Control
- Data Quality and Management
- Privacy-Preserving Technologies in Data
- HIV/AIDS Research and Interventions
- Psychology of Social Influence
- Zoonotic diseases and public health
- Healthcare Operations and Scheduling Optimization
Sanquin
2016-2025
Leiden University
2022
Utrecht University
2009-2018
University Medical Center Utrecht
2009-2018
Heidelberg University
2017
University Hospital Heidelberg
2017
Oklahoma State University Center for Health Sciences
2010-2016
Dutch Blood Transfusion Society
2015
National Institute for Public Health and the Environment
2008-2012
European Centre for Disease Prevention and Control
2012
The use of di-ethyl-hexyl-phthalate (DEHP) in medical devices will be banned the European Union from 1 July 2030, onwards. It is therefore important to evaluate performance non-DEHP blood collection system alternatives. Previously, we reported that red cell concentrates (RCCs) phosphate-adenine-glucose-guanosine-saline-mannitol (PAGGSM) stored containers did not result an increased transfusion reaction rate (TRR) as compared with saline-adenine-glucose-mannitol (SAGM)/DEHP-stored RCC....
Background Transfusion recipient data are needed for correct estimation of cost-effectiveness in terms outcomes after transfusion. Also, such essential monitoring blood use, future use and benchmarking. Study Design Methods A sample 20 93 Dutch hospitals was selected. Datasets containing all product transfusions between 1996 2006 were extracted from hospital bank computer systems, transfusion date, type characteristics as gender, address, date birth. The datasets appended matched to national...
BACKGROUND Whole blood donors are at risk of becoming iron deficient. To monitor stores, Sanquin implemented a new deferral policy based on ferritin levels, in addition to the traditional hemoglobin measurements. METHODS Ferritin levels determined every fifth donation, as well all first‐time donors. Donors with <15 ng/mL (WHO threshold) deferred for 12 months; those ≥15 and ≤30 6 months. The first results were analyzed presented here. RESULTS show that 25% women (N = 20151, 95% CI...
BACKGROUND: Concerns have been raised that aging of the general population will increase demand for blood products. Modeling can be applied to assess trends in and supply predict how these develop over time. STUDY DESIGN AND METHODS: We developed mathematical models describe national red cell (RBC) The first model assumes mean numbers transfusions per inhabitant age sex are constant. A second incorporates observed changes clinical use Further, a donation is future RBC supply. To estimate...
Risk behavior-based donor selection procedures are widely used to mitigate the risk of transfusion-transmissible infections (TTIs), but their effectiveness is disputed in countries with low residual risks TTIs.In 1995 2014, Dutch blood donors infected hepatitis B virus (HBV), C (HCV), human immunodeficiency (HIV), T-lymphotropic (HTLV), or syphilis were interviewed by trained medical counselors identify factors associated TTIs. Trends prevalence and incidence TTIs analyzed using binomial...
BACKGROUND The incidence of hepatitis E virus (HEV) has increased substantially in Europe recently, thereby threatening blood safety. A cost‐effectiveness analysis for HEV screening donations the Netherlands was performed. STUDY DESIGN AND METHODS simulation model developed to mimic process donation, infections donor population, donation testing, and transmission transfusion recipients. variability viral loads among donors modeled using observed loads. number (incurable) chronic organ stem...
A ubiquitous issue in research is that of selecting a representative sample from the study population. While random sampling strategies are gold standard, practice, participants not always feasible nor necessarily optimal choice. In our case, selection must be made 12 hospitals (out 89 Dutch total). With this hospitals, it should possible to estimate blood use remaining as well. paper, we evaluate both and purposive for case estimating hospitals. Available population-wide data on hospital...
Summary. Inhibitory antibodies to exogenous FVIII/FIX are a major complication of haemophilia treatment. Up 30% previously untreated patients (PUPs) with severe A develop inhibitors, most likely during the initial 50 exposure days concentrate. In addition classical cohort studies, European monitoring system (EUHASS) has been set up evaluate inhibitor development in PUPs. The present study addresses reliability estimating cumulative incidence this registry. Data from retrospective CANAL...
Severe hemophilia requires life-long treatment with expensive clotting factor concentrates; studies comparing effects of different therapeutic strategies over decades are very difficult to perform. A simulation model was developed evaluate the long-term outcome on demand, prophylactic and mixed for patients severe A.A computer based individual patients' data from a Dutch cohort study in which intermediate dose prophylaxis used French demand used, multivariate regression analyses. This...
BACKGROUND: During the past decade, blood screening tests such as triplex nucleic acid amplification testing (NAT) and human T‐cell lymphotropic virus type I or (HTLV‐I/II) antibody were added to existing serologic for hepatitis B (HBV), immunodeficiency (HIV), C (HCV). In some low‐prevalence regions these additional yielded disputable benefits that can be valuated by cost‐effectiveness analyses (CEAs). CEAs are used support decision making on implementation of medical technology. We present...
Background A timely risk assessment is desired to guide decisions on preventive transfusion safety measures during emerging infectious disease ( EID ) outbreaks. The E uropean Up‐Front Risk Assessment Tool EUFRAT model was developed provide quantitative transmission estimates of EIDs through blood transfusion. Study Design and Methods generic comprises five sequential steps estimate the infection risks in chain: 1) prevalence donor population, 2) obtaining infected donations, 3) components,...
Pathogen reduction (PR) of selected blood components is a technology that has been adopted in practice various ways. Although they offer great advantages improving the safety supply, these technologies have limitations which hinder their broader use, e.g. increased costs. In this context, European Centre for Disease Prevention and Control (ECDC), co-operation with Italian National Blood Centre, organised an expert consultation meeting to discuss potential role pathogen (PRT) as intervention...
When undergoing or about to undergo a needle-related procedure, most people are not aware of the adverse emotional and physical reactions (so-called vasovagal reactions; VVR), that might occur. Thus, rather than relying on self-report measurements, we investigate whether can predict VVR levels from video sequence containing facial information measured during blood donation. We filmed 287 donors throughout donation procedure where obtained 1945 videos for data analysis. compared 5 different...
Bacterial contamination is a life-threatening risk of blood transfusion, especially with platelet (PLT) transfusions. culturing (BCU) PLTs as well pathogen reduction (PRT) reduce the likelihood such contamination. The cost-effectiveness (CE) these interventions was analyzed after introduction diversion pouch during collection.The balance between costs and benefits preventing adverse events due to PLT transfusion assessed mathematical decision model Monte Carlo simulations. Model parameters...
Background and Objectives Despite increasingly meticulous haemovigilance reporting throughout the world, a systematic assessment of cost transfusion reactions is still lacking. This partly caused by fact that such an requires subjective expert additional costs linked to adverse reaction. Data on could support decision‐making regarding blood safety measures. Materials Methods Thirteen experts from nine hospitals were asked estimate care required following various types reactions. Additional...
Many studies already reported on the association between patient characteristics severity of COVID-19 disease outcome, but relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study which used IgG response from 11,118 longitudinal measurements 2,082 unique COVID convalescent plasma donors. symptoms and donor were obtained by questionnaire. Antibody responses modelled using linear mixed-effects model. Our...
Cost-effectiveness analyses of blood safety interventions require estimates the life expectancy after product transfusion. These are best derived from survival transfusion, per age group and component type.In PROTON (PROfiles TransfusiON recipients) study transfusion recipient data was collected a hospital sample covering 28% total use between 1996 2006 in Netherlands. The dataset includes date type transfused identification details. were individually matched to mortality Survival first any...
SUMMARY On account of the serious complications hepatitis C virus (HCV) infection and improved treatment possibilities, need to improve HCV awareness case-finding is increasingly recognized. To optimize a future national campaign with this objective, three pilot campaigns were executed in regions The Netherlands. One was aimed at general population, second (similar) extended support programme for primary care third specifically hard-drug users. Data from used build mathematical model...
Background The Q fever outbreaks in the N etherlands 2007 to 2009 initiated discussion on necessity of measures prevent transmission through blood products. Risk assessments help transfusion regulators decide when and where are required. This study assesses ( TT ) risk using E uropean U p‐ F ront R isk A ssessment T ool EUFRAT model. Study Design Methods We estimated number infections recipients during outbreaks' peaks selected notification data; estimates calculated from probability a donor...
Hepatitis C virus infection (HCV) is a serious, but underdiagnosed disease that can generally be treated successfully. Therefore, nationwide HCV awareness campaign was implemented in the Netherlands targeting people who inject drugs (PWID) addiction care ('PWID intervention') and high-risk groups general population ('public intervention'). The objective of this study to assess effectiveness cost-effectiveness interventions used campaign. For 'PWID' intervention, all centres provided...
Abstract Background During pregnancy, maternal red blood cell (RBC) antibodies can lead to life‐threatening fetal hemolysis and anemia. Women become immunized by a pregnancy or an unmatched transfusion. Our aim was quantify the effect of nationwide K‐matched transfusion policy for women childbearing age potential prevent K‐immunization in pregnancy. Study Design Methods In this nation‐wide change evaluation study we determined occurrence RBC before after introduction evaluated cause K...