A5023420583- Blood donation and transfusion practices
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Blood transfusion and management
- Viral gastroenteritis research and epidemiology
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Child Nutrition and Feeding Issues
- COVID-19 Pandemic Impacts
- Restless Legs Syndrome Research
- COVID-19 epidemiological studies
- Tattoo and Body Piercing Complications
- Folate and B Vitamins Research
- Influenza Virus Research Studies
- Sexuality, Behavior, and Technology
- Parkinson's Disease Mechanisms and Treatments
- SARS-CoV-2 detection and testing
- Child Nutrition and Water Access
- Blood Pressure and Hypertension Studies
Sanquin
2020-2025
Public Health Service of Amsterdam
2023-2024
Amsterdam University Medical Centers
2023-2024
Amsterdam UMC Location University of Amsterdam
2023-2024
University Medical Center Utrecht
2019-2020
Utrecht University
2019
ABSTRACT BACKGROUND Regular blood donation is associated with an increased risk of iron deficiency (ID; ferritin <15 µg/L). Oral supplementation known to shorten store recovery time and could serve as a more effective alternative extended intervals. We aimed determine the optimal ferritin-guided protocol in terms donor health, side-effects, return, treatment adherence. METHODS In this prospective randomized placebo-controlled trial donors levels ≤30 µg/L were enrolled study randomly...
Abstract Background Traditionally, during crises the number of new blood donors increases. However, current coronavirus disease 2019 (COVID‐19) pandemic created additional barriers to donate due governmental prevention measures and increased personal health risks. In this report, we examined how affected donor registrations in Netherlands, especially among groups with higher risk profiles for severe COVID‐19. Additionally, explored role media donation registrations. Study Design Methods We...
Abstract Background and Objectives In the Netherlands, as of April 2018, upper age limit for blood donation has been raised from 69 to 79 years, providing an opportunity study older donors' perspectives regarding donating at age. This aims explore whether donors agree with increase limit, if they feel obliged continue donating, identify their motivators barriers describe donation‐related experiences complications. Materials Methods An online survey was distributed among Dutch aged 68–73...
Abstract Background Blood donors are at risk for reduced iron stores, because of which donor monitoring received increased attention in the last decade. Despite importance health, international consensus on an appropriate policy is lacking. Therefore, we conduct a trial to evaluate what extent ferritin-guided donation intervals effective increasing haemoglobin and ferritin levels, decreasing low-haemoglobin deferral, return improving health whole blood Netherlands. Methods Sanquin Bank...
Many studies already reported on the association between patient characteristics severity of COVID-19 disease outcome, but relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study which used IgG response from 11,118 longitudinal measurements 2,082 unique COVID convalescent plasma donors. symptoms and donor were obtained by questionnaire. Antibody responses modelled using linear mixed-effects model. Our...
Abstract Background Less discriminatory donor selection policies for men who have sex with (MSM) may impact transfusion safety in terms of higher residual risks known transfusion‐transmitted infections (TTIs), increased vulnerability toward new TTIs that are also transmitted via sex, and HIV masked by pre‐exposure prophylaxis (PrEP). Study Design Methods TTI trends Dutch donors were studied over a 13‐year period (2011–2023), characterized successive relaxations MSM deferral criteria....
Abstract Introduction Whole blood donors are at increased risk for iron deficiency (ID). ID anemia is associated with several symptoms, such as fatigue, cognitive dysfunction, pica, and restless leg syndrome (RLS). However, it unclear if these symptoms also occur when a donor has developed without anemia. This study aims to determine whether non‐anemic (NAID) the occurrence of ID‐related symptoms. Study Designs Methods We combined data from three studies in whole (i.e., Donor Insight‐III,...
Awareness of infection with SARS-CoV-2 is crucial for the effectiveness COVID-19 control measures. Here, we investigate awareness and symptoms in relation to antibodies against healthy plasma donors. We asked individuals donating across Netherlands between May 11th 18th 2020 report COVID-19-related symptoms, tested indicative a past SARS-CoV-2. Among 3,676 antibodies, from questionnaire data, 239 (6.5%) are positive antibodies. Of those, 48% suspect no COVID-19, despite majority reporting...
Background Frequent whole blood donors have an increased risk of developing iron deficiency. Iron deficiency can detrimental health effects when left untreated. Donation intervals are commonly too short to replenish stores and extending these reduces donor availability. Oral supplementation is known shorten store recovery time but may also induce gastrointestinal complaints. We aim optimise the effectiveness supplements while minimising risks side effects. Therefore, we will evaluate impact...
Abstract Background and Objectives Iron supplementation is an effective strategy to mitigate donation‐induced iron deficiency in blood donors. However, evidence on the perception of individuals involved donation as a service policy lacking. This study aimed evaluate knowledge whole donors (donors), collection staff (collection staff) donor physicians (physicians) regarding loss supplementation. Materials Methods Online focus group discussions had four six participants followed structured...
Abstract Background and Objectives Regular whole blood donations are associated with an increased risk of iron deficiency. Iron supplementation is effective strategy to prevent donation‐induced However, research on donor perceptions towards such a policy limited. Therefore, we aim evaluate donors' knowledge depletion their regarding as service policy. Materials Methods Three thousand Dutch donors were invited complete survey assessing attitudes Linear regression modelling was used...
Abstract Background To better balance the safety of blood supply and inclusion men who have sex with (MSM), further improvements are needed to risk management strategy employed in Netherlands reduce transfusion‐transmissible infections (TTIs). A gender‐neutral individual assessment could provide a solution by determining donor eligibility based on sexual behaviors known increase TTIs. Our objective is estimate proportion donors that would be deferred such an assessment, as well their...
Abstract While donating blood during the COVID‐19 pandemic offers individuals a possibility to contribute their community, donation also exposes donors additional risks, as physical distancing is impossible donation. This study explored what motivated and plasma in Netherlands donate pandemic, order identify potential focus points for donor recruitment future crises. In total, 3175 of invited 7286 who donated between 1 14 April 2020 participated an online questionnaire including questions...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic challenges governments worldwide to balance appropriate virus control measures and their societal economic consequences. These include the identification, isolation testing of potentially infected individuals. As this relies on an individual’s awareness infection, we investigated extent which healthy adults suspected having had COVID-19, how COVID-19 suspicion symptoms relate antibodies indicative a past infection with...
Abstract Background Whole blood donors may experience post‐donation symptoms such as fatigue, dizziness, or headache after donation, which could influence donor retention. We aimed to examine during 1 week whole investigate characteristics associated with symptoms, and evaluate associations between return. Methods During week, who donated successfully at one of the collection centers in The Netherlands were invited participate. Three thousand seventy six filled a diary, assessing days 6...
Abstract Background Whole blood donors are at increased risk for iron deficiency and anaemia. The current standard of haemoglobin (Hb) monitoring is insufficient to ensure the maintenance proper reserves donor health. We determine effects ferritin-guided donation intervals supply. Methods A interval policy was implemented evaluated through a stepped-wedge cluster-randomised controlled trial in all collection centres Netherlands. Ferritin measured new every 5th donation. Subsequent were...
To protect transfusion recipients from transfusion-transmissible infections, blood donors are deferred donating after recent tattooing or piercing. explore to what extent and how this deferral impacts donor availability, we performed an international study investigate many were for a tattoo piercing of these returned donate.We surveyed centre members the Biomedical Excellence Safer Transfusion (BEST) Collaborative European Blood Alliance Donor Studies Working Group on their numbers...
Introduction Serological surveillance is useful for assessing SARS-CoV-2 immunity in populations. To effectively study the presence and persistence of antibodies, it necessary to distinguish between persons with past infection, who only received vaccination. Knowledge duration antibody essential correct interpretation results. Methods Starting April 2020, waning antibodies was studied a longitudinal cohort 495 antibody-positive Dutch blood donors, not pre-selected by PCR testing or disease...