A5077113306- Travel-related health issues
- Mosquito-borne diseases and control
- Malaria Research and Control
- Parasites and Host Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral Infections and Vectors
- Platelet Disorders and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Hemoglobinopathies and Related Disorders
- Vector-borne infectious diseases
- Amoebic Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Parasitic Infections and Diagnostics
- Parasitic infections in humans and animals
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- Blood disorders and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Dermatological diseases and infestations
- COVID-19 epidemiological studies
- Rabies epidemiology and control
- Research on Leishmaniasis Studies
Erasmus MC
1997-2024
Erasmus University Rotterdam
1994-2024
Harbour BioMed (Netherlands)
2010-2021
Havenziekenhuis Rotterdam
2011-2020
University of Zurich
2016-2018
Hospital for Tropical Diseases
2009-2017
Universität Hamburg
2016
Mount Auburn Hospital
2016
University of Amsterdam
1999-2016
Boston University
2016
To understand the dynamics behind worldwide spread of mcr-1 gene, we determined population structure Escherichia coli and mobile genetic elements (MGEs) carrying gene. After a systematic review literature included 65 E. whole genome sequences (WGS), adding 6 recently sequenced travel related isolates, 312 MLST profiles. We 219 MGEs described in 7 Enterobacteriaceae species isolated from human, animal environmental samples. Despite high overall diversity, 2 lineages were observed that may...
The acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder with laboratory findings similar to those of congenital disease (vWD). Despite the numerous cases reported in literature until 1999 (n = 266), large studies on AvWS are not available. Moreover, diagnosis has been difficult and treatment empirical. These considerations prompted us organize an international registry. A questionnaire, devised collect specific information AvWS, was sent all members International Society...
Introduction Prompted by recent amendments of Yellow Fever (YF) vaccination guidelines from boost to single strategy and the paucity clinical data support this adjustment, we used profile YF-specific CD8+ T-cell subset profiles after primary neutralizing antibodies as a proxy for potentially longer lasting immunity. Methods Findings PBMCs serum were collected in six individuals on days 0, 3, 5, 12, 28 180, 99 >10 years YF-vaccination. Phenotypic characteristics YF- tetramer+ T-cells...
Yellow fever virus is a mosquito-borne flavivirus that causes yellow fever, an acute infectious disease occurs in South America and sub-Saharan Africa. Most patients with are asymptomatic, but among the 15% who develop severe illness, case fatality rate 20%-60%. Effective live-attenuated vaccines available protect against (1). An outbreak of began Brazil December 2016; since July 2017, cases both humans nonhuman primates have been reported from states São Paulo, Minas Gerais, Rio de Janeiro,...
The efficacy and safety of aspirin in the prevention treatment thrombosis essential thrombocythaemia (ET) was retrospectively analysed a cohort 68 ET patients. 41 patients presented with thrombosis, five bleeding; two had paradoxical combination bleeding at presentation. At presentation, significantly higher platelet leucocyte counts than thrombosis. During long‐term follow‐up incidence reduced receiving aspirin, either as monotherapy or cytoreduction. However, (500 mg/d) associated an...
Intravenous (IV) artesunate is the treatment of choice for severe malaria. In Europe, however, no GMP-manufactured product available and data in European travellers are scarce. Fortunately, became Netherlands Belgium through a named patient programme. This largest case series treated patients with malaria Europe.Hospitalized IV between November 2007 December 2010 were retrospectively evaluated. Patient characteristics, clinical outcome recorded on standardized form mortality, parasite...
Abstract Background Estimates of travel-related illness have focused predominantly on populations from highly developed countries visiting low- or middle-income countries, yet travel to and within high-income is very frequent. Despite being a top international tourist destination, few sources describe the spectrum infectious diseases acquired among travellers USA. Methods We performed descriptive analysis summarizing demographic characteristics, clinical diagnoses non-US-resident seen during...
Common problems in ill returned travelers to Brazil are dermatologic conditions, diarrhea, and febrile illnesses, especially dengue. Knowledge of potential risks can help clinicians advise attending large events care for those who become ill. Background. will host the 2014 FIFA World Cup 2016 Olympic Paralympic Games, that expected attract hundreds thousands international travelers. Travelers encounter locally endemic infections as well mass event–specific risks. Methods. We describe 1586...
Background: Zika virus has spread rapidly in the Americas and been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations epidemiology of disease travelers exposed Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel tropical medicine clinics 30 countries. Patients: Ill returned with a confirmed, probable, or clinically suspected diagnosis seen between January 2013 29 February 2016. Measurements: Frequencies demographic,...
There is increasing recognition of the contribution community-acquired cases to global burden Clostridium difficile infection (CDI). The epidemiology CDI among international travellers poorly understood, and factors associated with travel, such as antibiotic use changes in gut microbiota, could potentially put at higher risk.We summarized demographic, travel-associated geographic characteristics GeoSentinel database from 1997 2015. We also surveyed sites compare various testing indications,...
Cutaneous leishmaniasis (CL) may be emerging among international travellers and migrants. Limited data exist on mucocutaneous (MCL) in travellers. We describe the epidemiology of travel-associated CL MCL immigrants over a 20-year period through descriptive analysis GeoSentinel data.Demographic travel-related returned diagnosed with or at Surveillance Network site between 1 September 1997 31 August 2017 were analysed.A total 955 migrants travel-acquired (n = 916) during study period, whom 10%...
Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance travel-associated illness important.We evaluated travel-related encountered at EuroTravNet clinics, the European sub-network GeoSentinel, between March 1, 1998 and 31, 2018.103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, 2,880 (2.8%) during after travel. Despite increasing numbers patient encounters over 20 years, regions...
One hundred patients with a history of hemorrhoidal disease and suffering from an acute attack were randomized into two parallel groups treated Daflon 500 mg* (D500) or placebo (PL) under double-blind conditions. mg was administered at the dosage three tablets bid first four days following days. Overall improvement symptoms greater in D500 group than PL group, D2 up to D7. The clinical severity proctorrhagia, anal discomfort, pain, discharge diminished both but extent (P < 0.001 for all...
Abstract We describe a PCR-confirmed case of Plasmodium knowlesi infection with high parasitemia level and clinical signs severe malaria in migrant worker from Malaysian Borneo the Netherlands. Investigations showed that commercially available rapid antigen tests for detection human infections can detect P. humans.
A large outbreak of acute muscular sarcocystosis (AMS) among international tourists who visited Tioman Island, Malaysia, is described. Clinicians evaluating travelers returning ill from Malaysia with myalgia, or without fever, should consider AMS in their differential diagnosis. Background. Through 2 traveler-focused surveillance networks (GeoSentinel and TropNet), we identified investigated a (AMS), rarely reported zoonosis caused by protozoan parasite the genus Sarcocystis, associated...
Abstract Background Lymphocytopenia has frequently been described in patients with malaria, but studies on its association disease severity have yielded conflicting results. The neutrophil/lymphocyte count ratio (NLCR) introduced as a parameter for systemic inflammation critically ill and was found, together lymphocytopenia, to be better predictor of bacteraemia than routine parameters like C-reactive protein total leukocyte count. In the present study, predictive value NLCR lymphocytopenia...