David O. Freedman

ORCID: 0000-0002-5642-5257
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Travel-related health issues
  • Mosquito-borne diseases and control
  • Viral Infections and Vectors
  • Parasitic Diseases Research and Treatment
  • Parasites and Host Interactions
  • Hepatitis Viruses Studies and Epidemiology
  • Zoonotic diseases and public health
  • Malaria Research and Control
  • Viral Infections and Outbreaks Research
  • Vaccine Coverage and Hesitancy
  • Insect symbiosis and bacterial influences
  • Parasite Biology and Host Interactions
  • COVID-19 epidemiological studies
  • Influenza Virus Research Studies
  • Global Public Health Policies and Epidemiology
  • Vibrio bacteria research studies
  • Dermatological diseases and infestations
  • Climate Change and Health Impacts
  • Trypanosoma species research and implications
  • Global Health and Surgery
  • Data-Driven Disease Surveillance
  • Virology and Viral Diseases
  • Insects and Parasite Interactions
  • Vector-borne infectious diseases
  • Helminth infection and control

University of Alabama at Birmingham
2014-2024

University of Alabama
1990-2020

University Health Network
2016-2017

Island Health
2016-2017

University of Ottawa
2016-2017

Public Health Agency of Canada
2016-2017

Public Health Ontario
2016-2017

McGill University
1987-2017

Toronto Public Health
2017

Winnipeg Regional Health Authority
2017

Public health measures were decisive in controlling the SARS epidemic 2003. Isolation is separation of ill persons from non-infected persons. Quarantine movement restriction, often with fever surveillance, contacts when it not evident whether they have been infected but are yet symptomatic or infected. Community containment includes that range increasing social distancing to community-wide quarantine. Whether these will be sufficient control 2019-nCoV depends on addressing some unanswered questions.

10.1093/jtm/taaa020 article EN other-oa Journal of Travel Medicine 2020-02-10

Approximately 8 percent of travelers to the developing world require medical care during or after travel. Current understanding morbidity profiles among ill returned is based on limited data from 1980s.Thirty GeoSentinel sites, which are specialized travel tropical-medicine clinics six continents, contributed clinician-based sentinel surveillance for 17,353 travelers. We compared frequency occurrence each diagnosis returning regions world.Significant regional differences in proportionate...

10.1056/nejmoa051331 article EN New England Journal of Medicine 2006-01-11

David R. Hill, Charles D. Ericsson, Richard Pearson, Jay S. Keystone, O. Freedman, Phyllis E. Kozarsky, Herbert L. DuPont, Frank J. Bia, Philip Fischer, and Edward T. Ryan National Travel Health Network Centre Department of Infectious Tropical Diseases, London School Hygiene Medicine, London, England; University Toronto, Center for Toronto General Hospital, Ontario, Canada; Internal Clinical Texas Medical at Houston, St. Luke’s Houston Public Health, Baylor College Texas; Departments...

10.1086/508782 article EN Clinical Infectious Diseases 2006-11-17

Abstract We examined seasonality and annual trends for dengue cases among 522 returned travelers reported to the international GeoSentinel Surveillance Network. Dengue showed region-specific peaks Southeast Asia (June, September), South Central (October), America (March), Caribbean (August, October). Travel-related exhibited oscillations with several epidemics occurring during study period. In Asia, proportionate morbidity increased from 50 per 1,000 ill in nonepidemic years an average of...

10.3201/eid1407.071412 article EN cc-by Emerging infectious diseases 2008-07-01

We performed a descriptive analysis of acute and potentially life-threatening tropical diseases among 82,825 ill western travelers reported to GeoSentinel from June 1996 August 2011. identified 3,655 patients (4.4%) with total 3,666 diagnoses representing 13 diseases, including falciparum malaria (76.9%), enteric fever (18.1%), leptospirosis (2.4%). Ninety-one percent the had fever; median time travel presentation was 16 days. Thirteen (0.4%) died: 10 malaria, 2 melioidosis, 1 severe dengue....

10.4269/ajtmh.12-0551 article EN American Journal of Tropical Medicine and Hygiene 2013-01-17

Longitudinal data examining travel-associated illness patterns are lacking. To address this need and determine trends clusters in travel-related illness, we examined for 2000-2010, prospectively collected 42,223 ill travelers by 18 GeoSentinel sites. The most common destinations from which returned were sub-Saharan Africa (26%), Southeast Asia (17%), south-central (15%), South America (10%). proportion who traveled tourism decreased significantly, the to visit friends relatives increased....

10.3201/eid1907.121573 article EN cc-by Emerging infectious diseases 2013-06-11

A study was conducted in Lima, Peru to determine if patients with Strongyloides hyperinfection had human T cell lymphotropic virus type-1 (HTLV-I) infection. The included and a control group consisted of sex- age-matched asymptomatic healthy individuals whose stools were negative for Strongyloides. third intestinal strongyloidiasis. Sera from each subject tested HTLV-1/2I by an ELISA Western blot. HLTV-1 infection rates (85.7%, 18 21) significantly (P < 0.001) associated compared the...

10.4269/ajtmh.1999.60.146 article EN American Journal of Tropical Medicine and Hygiene 1999-01-01

Data on relative rates of acquisition gastrointestinal infections by travelers are incomplete. The objective this study was to analyze associated with oral ingestion pathogens in international relation place exposure. We performed a multicenter, retrospective observational analysis 6,086 ill enough any infection seek medical care at GeoSentinel clinic after completion travel during 2000 2005. determined regional and country‐specific reporting rate ratios (RRRs) comparison risk northern...

10.1111/j.1708-8305.2008.00203.x article EN Journal of Travel Medicine 2008-07-01

No systematic studies exist on sex and gender differences across a broad range of travel-associated diseases.Travel tropical medicine GeoSentinel clinics worldwide contributed prospective, standardized data 58,908 patients with illness to central database from 1 March 1997 through 31 October 2007. We evaluated in health outcomes demographic characteristics. Statistical significance for crude analysis dichotomous variables was determined using chi2 tests calculation odds ratios (ORs) 95%...

10.1086/650575 article EN Clinical Infectious Diseases 2010-02-15
Mary Wilson Lin H. Chen Pauline Han J. S. Keystone Jakob P. Cramer and 95 more Aluísio Augusto Cotrim Segurado DeVon C. Hale Mogens Jensenius Eli Schwartz Frank von Sonnenburg Karin Leder A. Plier Kenneth G. C. Smith Gerd Burchard Rahul Anand Stefanie S. Gelman Kevin C. Kain Andrea K. Boggild Cecilia Perret Fernando Valdivieso L Loutan François Chappuis Patricia Schlagenhauf Rainer Weber Robert Steffen Éric Caumes A. Pérignon Michael Libman B. Ward J. Dick MacLean Martin P. Grobusch Abraham Goorhuis P. de Vries Kartini Gadroen Frank P. Mockenhaupt Gundel Harms Philippe Parola Fabrice Simon J. Delmont H. Nord H. Laveran G. Carosi Francesco Castelli Bradley A. Connor Phyllis E. Kozarsky Henry H. L. Wu Jessica K. Fairley Carlos Franco‐Paredes J. Using Gabrielle Fröberg Helena Hervius Askling Ulf Bronner N. Jean Haulman David Roesel Elaine C. Jong Rogelio López‐Vélez José A. Pérez‐Molina Joseph Torresi Graham Brown Carmelo Licitra Alfonso Crespo Anne Marie McCarthy Vanessa Field John D. Cahill George McKinley Perry J.J. van Genderen Effrossyni Gkrania‐Klotsas William M. Stauffer Paul F. Walker Shuzo Kanagawa Yasuyuki Kato Y. Mizunno Marc Shaw Annemarie Hern Jean Vincelette David O. Freedman Susan Anderson Noreen A. Hynes R. Bradley Sack R. McKenzie Thomas B. Nutman Amy D. Klion C. Rapp Olivier Aoun Patrick Doyle Wayne Ghesquière Luis Valdez H. Siu N. Tachikawa Hanako Kurai Hironori Sagara David G. Lalloo Nicholas J. Beeching Alejandra Gurtman Susan McLellan Elizabeth D. Barnett Stefan Hagmann Maud Henry Andy O. Miller Marc Mendelson

Common problems in ill returned travelers to Brazil are dermatologic conditions, diarrhea, and febrile illnesses, especially dengue. Knowledge of potential risks can help clinicians advise attending large events care for those who become ill. Background. will host the 2014 FIFA World Cup 2016 Olympic Paralympic Games, that expected attract hundreds thousands international travelers. Travelers encounter locally endemic infections as well mass event–specific risks. Methods. We describe 1586...

10.1093/cid/ciu122 article EN Clinical Infectious Diseases 2014-02-28

‘Immunity passport’ (also called ''immunity certificate'' or license'' has been suggested to certify traveler’ protection from SARS-CoV-2 infection. Some data have demonstrated development of neutralizing antibodies that may protect against reinfection and reduce disease severity in the short-term, some tests correlate with virus neutralization. More evidence is needed on serologies for such certification facilitate travel, travelers their destination countries.

10.1093/jtm/taaa085 article EN other-oa Journal of Travel Medicine 2020-05-26

Qdenga (Takeda) is now WHO recommended for residents of highly endemic areas. Travellers from dengue non-endemic countries with previous travel-related (any serotype) will benefit TAK-003 vaccination to prevent a secondary infection during future risk travel. Dengue-naïve travellers have less potential and use remain discretionary now.

10.1093/jtm/taad132 article EN Journal of Travel Medicine 2023-10-01

GeoSentinel is a network of 22 member travel/tropical medicine clinics (14 in the United States and 8 other countries) initiated 1995 by International Society Travel Medicine (ISTM). based on concept that these are ideally situated to effectively detect geographic temporal trends morbidity among travelers. The core surveillance tool single-page faxable form submitted central data site for each post-travel patient, including immigrants, refugees, foreign visitors. Diagnoses entered either as...

10.1111/j.1708-8305.1999.tb00839.x article EN Journal of Travel Medicine 1999-06-01

Journal Article Lymphoscintigraphic Analysis Of Lymphatic Abnormalities In Symptomatic And Asymptomatic Human Filariasis Get access David O. Freedman, Freedman Division of Geographic Medicine, University Alabama at BirminghamNuclear Medicine Unit, Laboratorios Cerpe, and Centro des Pesquisas Aggeu MagalhaesRecife, Brazil Reprints or correspondence: Dr. Freedman. UAB Station, BBRB 206, Birmingham. AL 35294–2170. Search for other works by this author on: Oxford Academic PubMed Google Scholar...

10.1093/infdis/170.4.927 article EN The Journal of Infectious Diseases 1994-10-01

There is little information about naturally occurring protective immunity in individuals living areas endemic for lymphatic filariasis, though an immunologically hyperresponsive, uninfected group of "endemic normal" that may be immune has been previously recognized. To analyze the nature hyperresponsiveness and its potential relation to a state such individuals, strict clinical, parasitological, serological criteria were applied select seven "infection-free" normal (ENs) from population 459...

10.1172/jci113850 article EN Journal of Clinical Investigation 1989-01-01

Among ill returned travelers to Schistosoma -endemic areas reported the GeoSentinel Surveillance Network over a decade 410 schistosomiasis diagnoses were identified: 102 mansoni , 88 S. haematobium 7 japonicum and 213 unknown human species. A total of 83% acquired in Africa. Unlike previous large case series, individuals born endemic excluded. Controlling for age sex, those traveling missionary or volunteer work, as expatriates more likely be diagnosed with schistosomiasis. Sixty-three...

10.4269/ajtmh.2008.79.729 article EN American Journal of Tropical Medicine and Hygiene 2008-11-01

Fascioliasis is highly endemic in the Andean region of South America. Newer serological assays have improved our ability to diagnose acute fascioliasis. The diagnosis was established by Fasciola hepatica serology (Fas2-ELISA or Western blot) 10 patients. Identifiable exposure included ingestion watercress (N = 8), alfalfa juice 5), and lettuce 1). Computed tomography abdomen showed hepatomegaly 9), track-like hypodense lesions with subcapsular location hematoma 2). Radiologic sequelae cyst...

10.4269/ajtmh.2008.78.222 article EN American Journal of Tropical Medicine and Hygiene 2008-02-01
Coming Soon ...