A5087184420- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Neonatal Health and Biochemistry
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Toxoplasma gondii Research Studies
- Neonatal and Maternal Infections
- Dermatological and COVID-19 studies
- Disaster Response and Management
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Polyomavirus and related diseases
- Mosquito-borne diseases and control
- Liver Disease Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Viral Infections and Immunology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Hepatitis Viruses Studies and Epidemiology
Leiden University Medical Center
2015-2025
National Institute for Public Health and the Environment
2009-2017
Imperial College Healthcare NHS Trust
2017
Kingston Hospital
2017
Hospital Universitario Puerta de Hierro Majadahonda
2017
Czech Academy of Sciences, Institute of Microbiology
2012
Leiden University
2010-2011
Azienda Ospedaliero Universitaria Ospedali Riuniti
2011
Istituto Oncologico Veneto
2011
Amsterdam UMC Location University of Amsterdam
2009
Parvovirus B19V (B19V) infection during pregnancy can be complicated by potentially life-threatening fetal hydrops, which managed intrauterine transfusion (IUT). This study investigates the long-term temporal patterns in epidemiology of and evaluates impact on combining data infections from Dutch Sentinel Surveillance system period 1990 to 2023, blood banking hospital hydrops. Using wavelet analysis, we identified annual epidemic cycles Netherlands 1990-2019 superimposed multiannual...
Abstract On July 10, 2008, Marburg hemorrhagic fever was confirmed in a Dutch patient who had vacationed recently Uganda. Exposure most likely occurred the Python Cave (Maramagambo Forest), which harbors bat species that elsewhere Africa have been found positive for virus. A multidisciplinary response team convened to perform structured risk assessment, classification of contacts, issue guidelines follow-up, provide information, and monitor crisis response. In total, 130 contacts were...
The hypothesis that elimination of facultative and strict anaerobic microorganisms from the gastro-intestinal tract by antimicrobial drugs in period time around allogeneic bone marrow transplantation (BMT) prevents acute graft-versus-host disease (GVHD), was examined a cohort 112 children grafted between 1989 2002 for hematological malignancies. All patients received T-cell replete human leukocyte antigens (HLA) matched sibling donors under identical conditions. To eliminate tract, total...
ObjectiveTo assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment this group.Study designA nationwide, non-randomized controlled trial, comparing six weeks oral to cCMV, recruited after newborn screening resulted referral. The choice whether treat was left parents subjects. Eligible subjects were full term aged <13 sensorineural diagnosed cCMV through dried blood spot...
BackgroundImplementation of yellow fever vaccination is currently hampered by limited supply vaccine. An alternative route administration with reduced amounts vaccine but without loss efficacy would boost programmes.Methods and FindingsA randomized, controlled, non-inferiority trial was conducted in a Dutch university center between August 2005 February 2007. A total 155 primary vaccinated 20 previously volunteers participated. Participants were randomly assigned 1∶1 ratio to receive...
Aim This study aimed to estimate long‐term impairment attributable congenital cytomegalovirus infection ( cCMV ). Method nationwide cohort retrospectively assessed in children born 2008 the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of ‐positive n =133) and matched ‐negative comparison =274) up 6 years age were analysed. Results Moderate severe was diagnosed 24.8% (33 out 133) all (53.8% symptomatic, 17.8% asymptomatic), compared with 12.0% 274)...
Cytomegalovirus (CMV) infection has been reported to contribute the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV not evaluated as a possible risk factor for 2 Our aim was investigate potential associations between seropositivity, IgG antibody level glucose regulation in oldest old.CMV seropositive subjects were more likely have (17.2% vs 7.9%, p = 0.016), had higher HbA1c (p 0.014) non-fasting 0.024) olds. These remained significant after adjustment...
Cytomegalovirus (CMV) is the most common infectious cause of congenital malformation and a leading developmental disabilities such as sensorineural hearing loss (SNHL), motor cognitive deficits. The significant disease burden from CMV infection (cCMV) led US National Institute Medicine to rank vaccine development highest priority. An average 6.7/1000 live births are affected by cCMV, but prevalence varies across within countries. In contrast other infections rubella toxoplasmosis, cCMV...
Currently, the best option for patients with hepatitis delta is interferon alpha therapy at least one year. To evaluate effect of combination lamivudine–high‐dose therapy, we first treated eight chronic infection lamivudine 24 weeks; then was combined a high dose followed by regular (9 MU tiw). Follow‐up 12 weeks. Virological, biochemical and histological features were evaluated response to therapy. At baseline, all HBsAg positive in serum HDV RNA‐(PCR)positive plasma; HBV DNA undetectable...
Cytomegalovirus (CMV) infections after transplantation are commonly treated using a prophylactic or preemptive regimen with (val)ganciclovir. It remains unclear, which approach is most effective in preventing CMV disease D+R- patients. The aim of this retrospective study was to compare the treatment response and antiviral resistance between two regimens renal transplant recipients.Before 2006, valganciclovir applied (42 patients). From 2006 onwards, patients first received prophylaxis for 90...
Varicella zoster virus (VZV) infections are a relevant cause of morbidity and mortality in hematological patients especially hematopoietic stem cell transplant (HSCT) recipients. The present study aimed to investigate the prevalence clinical significance viral persistence antiviral resistance by systematically analyzing all episodes VZV diagnosed our laboratory pediatric adult between 2007 2010.Patient charts were reviewed document patient disease characteristics. loads determined available...
Human cytomegalovirus (CMV) is a herpes virus with poorly understood transmission dynamics. Person-to-person thought to occur primarily through transfer of saliva or urine, but no quantitative estimates are available for the contribution different infection routes. Using data from large population-based serological study (n = 5,179), we provide key epidemiological parameters, including transmissibility primary infection, reactivation, and re-infection. Mixture models fitted age- sex-specific...
Objective To evaluate clinical, audiological and neuroimaging findings in a cohort of infants diagnosed with congenital cytomegalovirus (cCMV) infection after failure at newborn hearing screening. Methods A prospective observational study the Netherlands, using existing screening infrastructure for well babies. Between July 2012 November 2016, (CMV) PCR testing neonatally obtained dried blood spots (DBS) was offered to all who failed Clinical, data were collected. Results DBS 1374...