A5023602626- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
- Toxoplasma gondii Research Studies
- Heart Rate Variability and Autonomic Control
- Pediatric health and respiratory diseases
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet and metabolism studies
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- Neonatal and Maternal Infections
National Institute for Public Health and the Environment
2014-2020
Leiden University Medical Center
2014-2017
Amsterdam UMC Location University of Amsterdam
2013
Emma Kinderziekenhuis
2013
University of Amsterdam
2013
Gelre Hospitals
2012
Utrecht University
2012
Aim This study aimed to estimate long‐term impairment attributable congenital cytomegalovirus infection ( cCMV ). Method nationwide cohort retrospectively assessed in children born 2008 the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of ‐positive n =133) and matched ‐negative comparison =274) up 6 years age were analysed. Results Moderate severe was diagnosed 24.8% (33 out 133) all (53.8% symptomatic, 17.8% asymptomatic), compared with 12.0% 274)...
Human cytomegalovirus (CMV) is a herpes virus with poorly understood transmission dynamics. Person-to-person thought to occur primarily through transfer of saliva or urine, but no quantitative estimates are available for the contribution different infection routes. Using data from large population-based serological study (n = 5,179), we provide key epidemiological parameters, including transmissibility primary infection, reactivation, and re-infection. Mixture models fitted age- sex-specific...
SUMMARY Congenital cytomegalovirus infection (cCMV) may lead to symptoms at birth and long-term consequences. We present a nationwide, retrospective cohort study on the outcome of cCMV up age 6 years. For this we identified cCMV, using polymerase chain reaction, by analysing dried blood spots, which are taken shortly after for neonatal screening. The group children with were compared who negative birth. Data collected about their health development Parents 73 693 invited participate, 32 486...
Objective Congenital cytomegalovirus infection (cCMV) can cause symptoms at birth as well long-term impairment. This study estimates cCMV-related healthcare costs in the Netherlands early childhood. Design, setting and patients In a nationwide retrospective cohort study, 156 children with cCMV were identified by testing 31 484 neonatal dried blood spots for cCMV. Use of resources first 6 years life matched cCMV-negative control group analysed. Mean per child calculated multiplying resource...
Congenital cytomegalovirus (cCMV) infection is the most common congenital worldwide and can lead to long-term impairments such as developmental delay. It currently unknown how this affects daily life of children their parents. Children For study, with cCMV were identified by testing stored dried blood spots 31,484 five-year-old born in 2008 Netherlands. Parents 133 274 without participated filled questionnaires on child’s development, parents’ quality life, care provided for consequences...
Infection with cytomegalovirus (CMV) is highly prevalent worldwide and can cause severe disease in immunocompromised persons congenitally infected infants. The burden caused by congenital CMV infection high, especially resource-limited countries. Vaccines are currently under development for various target groups. We evaluated the impact of vaccination strategies hygiene intervention using transmission models. Model parameters were estimated from a cross-sectional serological population study...
Abstract Congenital CMV infection (cCMV) is the most common congenital that can cause long-term impairment (LTI). The pathogenesis of LTI not completely understood. Fetal immunity may play a role in controlling and preventing LTI, although immune activation also contribute to fetal immunopathology. In this study, we analyzed various molecular markers T B cell numbers neonatal dried blood spots 99 children with cCMV 54 without cCMV: δRec-ψJα signal joints on TCR excision circles, intron...
Abstract Human cytomegalovirus is a herpes virus with poorly understood transmission dynamics. We here provide quantitative estimates of the transmissibility primary infection, reactivation, and re-infection using age-and sex-specific antibody response data. The data are optimally described by three distributions measurements, i.e. uninfected, infected, infected after reactivation/re-infection. Estimates seroprevalence increase gradually age, such that at 80 years 73% (95%CrI: 64%-78%)...