A5005198723- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Child and Adolescent Health
- Infant Development and Preterm Care
- Cytomegalovirus and herpesvirus research
- Child Abuse and Trauma
- Hearing Impairment and Communication
- Language Development and Disorders
- Breastfeeding Practices and Influences
- Herpesvirus Infections and Treatments
- Down syndrome and intellectual disability research
- Homicide, Infanticide, and Child Abuse
- Infant Health and Development
- Congenital Diaphragmatic Hernia Studies
- Parvovirus B19 Infection Studies
- Family and Disability Support Research
- Emergency and Acute Care Studies
- Neonatal Respiratory Health Research
- Ear Surgery and Otitis Media
- Pediatric health and respiratory diseases
- Child Nutrition and Feeding Issues
- Neonatal Health and Biochemistry
- Interpreting and Communication in Healthcare
- Child Abuse and Related Trauma
- Restraint-Related Deaths
Leiden University Medical Center
2012-2024
Amgen (United States)
2024
Garvan Institute of Medical Research
2021
Leiden University
2009-2020
Willem-Alexander Kinderziekenhuis
2014-2020
University of Amsterdam
2018
University of the Humanities
2018
University of South Carolina
2017
Hague Institute for Global Justice
2014
Pediatrics and Genetics
2012
Newborn hearing screening programs have been implemented in many countries because it was thought that the earlier permanent childhood impairment is detected, less developmentally disadvantaged children would become. To date, however, no strong evidence exists for universal introduction of newborn screening.To study effect vs distraction screening, conducted at 9 months age, on development, spoken communication, and quality life.Between 2002 2006, all 65 regions The Netherlands replaced with...
ObjectiveTo assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment this group.Study designA nationwide, non-randomized controlled trial, comparing six weeks oral to cCMV, recruited after newborn screening resulted referral. The choice whether treat was left parents subjects. Eligible subjects were full term aged <13 sensorineural diagnosed cCMV through dried blood spot...
Prevalence of overweight in children is increasing, causing various health problems. This study aims to establish growth references for weight and assess the prevalence rates obesity a nationwide sample Dutch with Down syndrome (DS), taking into account influence comorbidity.In 2009, longitudinal data from trisomy 21 who were born after 1982 retrospectively collected medical records 25 regional specialized DS centers. "Healthy" was defined as not having concomitant disorders or only mild...
Aim This study aimed to estimate long‐term impairment attributable congenital cytomegalovirus infection ( cCMV ). Method nationwide cohort retrospectively assessed in children born 2008 the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of ‐positive n =133) and matched ‐negative comparison =274) up 6 years age were analysed. Results Moderate severe was diagnosed 24.8% (33 out 133) all (53.8% symptomatic, 17.8% asymptomatic), compared with 12.0% 274)...
Abstract Craniosynostosis, the premature fusion of one or more cranial sutures, is a developmental defect that disrupts morphogenetic program, leading to variable dysmorphic craniofacial features and associated functional abnormalities. Craniosynostosis frequently observed as an feature in number clinically genetically heterogeneous syndromic conditions, including group disorders caused by activating mutations genes coding for fibroblast growth factor receptor family members FGFR1, FGFR2,...
Objective To provide cross-sectional height and head circumference (HC) references for healthy Dutch children with Down syndrome (DS), while considering the influence of concomitant disorders on their growth, to compare growth between DS from general population. Study design Longitudinal medical data were retrospectively collected records in 25 30 regional hospital-based outpatient clinics Netherlands. Children Trisomy 21 karyotype descent born after 1982 included. The LMS method was applied...
Objective To evaluate clinical, audiological and neuroimaging findings in a cohort of infants diagnosed with congenital cytomegalovirus (cCMV) infection after failure at newborn hearing screening. Methods A prospective observational study the Netherlands, using existing screening infrastructure for well babies. Between July 2012 November 2016, (CMV) PCR testing neonatally obtained dried blood spots (DBS) was offered to all who failed Clinical, data were collected. Results DBS 1374...
Since 2002, the World Health Organization and many governments professional associations have recommended exclusive breastfeeding for 6 months followed by complementary feeding (giving solid foods alongside breast milk) as optimal infant practice. Several articles been published challenging this recommendation. Arguably, most influential has 2008 commentary of European Society Pediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) Committee on Nutrition, which that should be introduced...
Objective: The aim of this study is to investigate whether the quality Dutch, community based, universal newborn hearing screening programme consistent over time. Design: Universal data from three cohorts are compared on a number targets concerning outcome and process in stage, programme. Study sample: A total 552 820 children entered (189 794 2002–2006; 181 574 2008, 452 2009). Results: Participation high implementation onwards increases time for all screen stages percentages above 99%....
Objectives: The first aim of this study was to examine various aspects Theory Mind (ToM) development in young children with moderate hearing loss (MHL) compared peers. second the relation between language abilities and ToM both groups. third compare sequence MHL Design: Forty-four 3 5 years old (35 70 dB HL) who preferred use spoken were identified from a nationwide on children. These 101 Children observed during several tasks measure intention understanding, acknowledgement other’s desires,...