A5048394409- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Liver Disease and Transplantation
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Blood groups and transfusion
- Diabetes Treatment and Management
- Bone and Joint Diseases
- Viral gastroenteritis research and epidemiology
- Lipoproteins and Cardiovascular Health
- Travel-related health issues
- Eosinophilic Esophagitis
- Drug-Induced Adverse Reactions
- Polyomavirus and related diseases
University Medical Center Utrecht
2016-2025
Maastricht University Medical Centre
2025
Maastricht University
2023-2024
Utrecht University
2005-2022
University Medical Center
2012-2020
ViiV Healthcare (Spain)
2019
Gilead Sciences (United Kingdom)
2019
University Hospital Heidelberg
2010-2018
Heidelberg University
2010-2018
University Hospital and Clinics
2018
Direct-acting antivirals (DAAa) cure hepatitis C virus (HCV) infections in 95% of infected patients. Modeling studies predict that universal HCV treatment will lead to a decrease the incidence new but real-life data are lacking. The among Dutch human immunodeficiency (HIV)-positive men who have sex with (MSM) has been high for >10 years. In 2015 DAAs became available all patients and resulted rapid uptake HIV-positive MSM. We assessed whether this was followed by infections.Two prospective...
Background. Since 2000, incidence of sexually acquired hepatitis C virus (HCV)-infection has increased among human immunodeficiency (HIV)-infected men who have sex with (MSM). To date, few case-control and cohort studies evaluating HCV transmission risk factors were conducted in this population, most these initially designed to study HIV-related behavior characteristics. Methods. From 2009 onwards, HIV-infected MSM acute infection controls (HIV-monoinfected MSM) prospectively included the...
Objectives: To investigate the short- and long-term dynamics of intact defective proviral HIV DNA during ART. Design: We evaluated viral reservoir in a cohort nine individuals with chronic HIV-1 subtype B infection who initiated first-line ART were followed for 20 years while continuing Methods: PBMCs obtained before (n = 5), first year, after 8.5 treatment. T cell subsets (naive, central-memory, transitional-memory effector-memory) sorted at years. was isolated analyzed using assay (IPDA)....
The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide hepatitis C virus (HCV) treatment uptake among patients coinfected with human immunodeficiency (HIV) and HCV.Data were obtained from ATHENA HIV observational cohort in which >98% of HIV-infected ever registered 1998 are included. Patients included if they had 1 positive HCV RNA result, did not have spontaneous clearance, known still be care. Treatment outcome...
Abstract Background Human immunodeficiency virus (HIV)-positive men who have sex with (MSM) are at high risk of hepatitis C (HCV) reinfection following clearance HCV, but factors specifically for never been comprehensively assessed. Methods Using data from a prospective observational cohort study among HIV-positive MSM an acute HCV infection (MOSAIC), the incidence spontaneous or successful treatment was A univariable Bayesian exponential survival model used to identify associated...
To investigate whether T-cell activation and exhaustion is linked to HCV- HIV disease parameters in HIV/HCV infected individuals, we studied characteristics coinfected patients controls.14 coinfected, 19 HCV monoinfected, 10 monoinfected 15 healthy controls were included this cross-sectional study. Differences expression of markers (HLA-DR, CD38, PD-1, Tim-3 Fas) phenotypic on CD4(+) CD8(+) T-cells analysed by flow cytometry related (HCV-viremia, ALT liver fibrosis).Frequencies activated...
A decline of hepatitis C virus (HCV) antibody titers (anti-HCV), ultimately resulting in seroreversion, has been reported following clearance viremia both acute and chronic HCV infection. However, frequency seroreversion remains unknown human immunodeficiency (HIV)/HCV-coinfected patients. We describe anti-HCV dynamics among HIV-infected men who have sex with (MSM) infection reinfection.Primary was assumed when a subject negative prior to the first positive RNA test. Anti-HCV measured at...
The Netherlands is one of the six European countries considered on track to eliminate hepatitis C virus by 2030. To achieve this goal, continuous efforts have be put into designing efficient case-finding strategies, including retrieval previously diagnosed virus-infected who are lost follow-up.To trace and treat all follow-up patients in Utrecht region create an strategy that can used future (national) initiatives.Positive diagnostic tests (anti-hepatitis IgG or virus-RNA) from laboratory...
Tenofovir was licensed for use in patients with HIV 2001 and since then has become a firmly established anti-retroviral both guidelines routine practice. Data have been presented from many pivotal studies—informing on its efficacy, use, adverse features—and there are also over 7.5 million patient-years of experience to date. We explore the data this nucleotide reverse transcriptase inhibitor 2008—focusing side effects, utility.
Abstract Background & Aims Mucosal‐associated invariant T ( MAIT ) cells are important innate with antimicrobial and immunoregulatory activity, recently found to be depleted in blood of patients HIV HCV mono‐infections. In this study, we assessed the impact , / co‐infection on circulating intrahepatic ‐cells correlations liver fibrosis. Methods cross‐sectional nine healthy subjects, 20 22 co‐infected were included. Blood fine needle aspirate biopsies studied using flowcytometry for CD 3...
Background: People living with HIV (PLWH) experience a higher cardiovascular disease (CVD) risk. Yet, traditional algorithms are often used to estimate CVD We evaluated the performance of 4 commonly algorithms. Setting: The Netherlands. Methods: data from 16,070 PLWH aged ≥18 years, who were in care between 2000 and 2016, had no pre-existing CVD, initiated first combination antiretroviral therapy >1 year ago, available on CD4 count, smoking status, cholesterol, blood pressure. Predictive...
Chronic hepatitis B has a variable course in disease activity with risk of clinical complications like liver cirrhosis and hepatocellular carcinoma. As symptoms present late stage the disease, identification factors is important for early detection therefore improvement prognosis. Recently, two REVEAL-HBV studies from Taiwan have shown positive correlation between viral load at any point time development Due to differences host Asians other populations, it unclear whether these results can...