A5073711055- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Energy Harvesting in Wireless Networks
- Bacteriophages and microbial interactions
- Molecular Biology Techniques and Applications
- Animal Virus Infections Studies
- Tumors and Oncological Cases
Leiden University Medical Center
2018-2023
Sanquin
2018-2021
University of Oxford
2020
The polyomavirus family currently includes thirteen human (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis nephropathy (BKPyV), Merkel cell carcinoma (MCPyV), trichodysplasia spinulosa (TSPyV). Some recently discovered polyomaviruses of still unknown prevalence pathogenic potential. Because infections persist might be transferred by blood components patients, we studied...
Metagenomic high-throughput sequencing (mHTS) is a hypothesis-free, universal pathogen detection technique for determination of the DNA/RNA sequences in variety sample types and infectious syndromes. mHTS still its early stages translating into clinical application. To support development, implementation standardization procedures virus diagnostics, European Society Clinical Virology (ESCV) Network on Next-Generation Sequencing (ENNGS) has been established. The aim ENNGS to bring together...
The family of polyomaviruses, which cause severe disease in immunocompromised hosts, has expanded substantially recent years. To accommodate measurement IgG seroresponses against all currently known human polyomaviruses (HPyVs), including the Lyon IARC polyomavirus (LIPyV), we extended our custom multiplex bead-based HPyV immunoassay and evaluated performance this pan-HPyV immunoassay. VP1 proteins 15 HPyVs belonging to 13 Polyomavirus species were expressed as recombinant glutathione...
Abstract BACKGROUND Human polyomaviruses (HPyVs), like herpesviruses, cause persistent infection in a large part of the population. In immunocompromised and elderly patients, PyVs severe diseases such as nephropathy (BK polyomavirus [BKPyV]), progressive multifocal leukoencephalopathy (JC [JCPyV]), skin cancer (Merkel cell [MCPyV]). Like cytomegalovirus, donor‐derived PyV can disease kidney transplant recipients. Possibly blood components transmit well. To study this possibility, first step...
Abstract The polyomavirus family currently includes thirteen human (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis nephropathy (BKPyV), Merkel cell carcinoma (MCPyV), trichodysplasia spinulosa (TSPyV). Some recently discovered polyomaviruses of still unknown prevalence pathogenic potential. Because infections persist might be transferred by blood components patients,...
The number of identified human polyomaviruses (HPyVs) has increased steadily over the last decade. Some novel HPyVs have been shown to cause disease in immunocompromised individuals. Lyon-IARC polyomavirus (LIPyV) belonging species Alphapolyomavirus quardecihominis was 2017 skin and saliva samples from healthy Since its initial discovery, LIPyV rarely detected clinical but faeces cats with diarrhoea. Serological studies show low seroprevalence populations. To investigate possibility that is...
Human polyomaviruses (HPyVs) cause disease in immunocompromised patients. BK polyomavirus (BKPyV) for instance persistently infects the kidneys. In kidney transplant recipients, (KTRs) BKPyV can allograft nephropathy. JCPyV, MCPyV, TSPyV and HPyV9 reside kidneys too, or have been detected urine. this study, we investigate exposure to after transplantation by serological means. Serum samples from 310 KTR collected before 6 months (n = 620), 279 corresponding donors transplantation, blood...
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