A5081572349- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Organ and Tissue Transplantation Research
- Full-Duplex Wireless Communications
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Energy Harvesting in Wireless Networks
- Cytomegalovirus and herpesvirus research
- Antenna Design and Analysis
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
Leiden University Medical Center
2019-2024
The main challenge of immunosuppressive therapy after solid organ transplantation is to create a new immunological balance that prevents rejection and does not promote opportunistic infection. Torque teno virus (TTV), ubiquitous non-pathogenic single-stranded DNA virus, has been proposed as marker functional immunity in immunocompromised patients. Here we investigate whether TTV loads predict the risk common viral infection allograft kidney recipients. In retrospective cohort 389 recipients,...
The recommended immunosuppressive treatment after kidney transplantation consists of tacrolimus, mycophenolate mofetil, and low-dose corticosteroids. Drug concentrations are monitored using therapeutic drug monitoring (TDM), which does not necessarily correlate with pharmacodynamic activity. To find the balance between optimal efficacy minimal toxicity, it might be more informative to monitor patients' immunological status rather than concentrations. We selected a panel T-cell-based immune...
Human polyomaviruses (HPyVs) cause disease in immunocompromised patients. BK polyomavirus (BKPyV) for instance persistently infects the kidneys. In kidney transplant recipients, (KTRs) BKPyV can allograft nephropathy. JCPyV, MCPyV, TSPyV and HPyV9 reside kidneys too, or have been detected urine. this study, we investigate exposure to after transplantation by serological means. Serum samples from 310 KTR collected before 6 months (n = 620), 279 corresponding donors transplantation, blood...
BK polyomavirus (BKPyV) persistently infects the urinary tract and causes viremia nephropathy in kidney transplantation (KTx), recipients. In a previous study, we observed an increased incidence load of BKPyV KTx patients coinfected with human 9 (HPyV9). Here sought confirmation this observation explored whether novel HPyVs that have been detected urine (HPyV9 trichodysplasia spinulosa [TSPyV]) potentially aggravate infection.A well-characterized cohort 209 donor-recipient pairs was...
The detection and follow up of cytomegalovirus (CMV) Epstein-Barr virus (EBV) viral loads (VL) are crucial in the management immunocompromised patients. Recently, molecular CE-IVD assays for quantification CMV EBV have been launched use on random-access sample-to-result NeuMoDx 96 288 platforms (Qiagen).Evaluating qualitative quantitative performance clinical specimens compared to a lab developed tests (LDT) Abbott m2000 system.Both prospective retrospective panel, compiled non-detectable...
ABSTRACT BK polyomavirus‐associated nephropathy (BKPyVAN) is a well‐known complication of kidney transplantation (KTx). The mainstay prevention the reduction immunosuppression upon detection polyomavirus (BKPyV) DNAemia, which precedes BKPyVAN. However, this may inadvertently increase risk alloimmunity particularly in patients with high BKPyV DNA load, where significant often necessary. This single‐center, retrospective cohort study assesses de novo donor‐specific antibodies (dnDSA)...
Introduction: There is scant evidence to what extent maintenance immunosuppression quantitatively associated with BK viremia. We investigated the association between tacrolimus (tac) whole blood exposure and mycophenolic acid (mpa) plasma consecutive viremia within first year posttransplant. Methods: For this retrospective cohort study, 713 kidney transplant recipients (KTRs) transplanted at our center 2013-2018 treated Tac, mpa prednisolone, were selected from local database. Both trough...
Abstract The main challenge of immunosuppressive therapy after solid organ transplantation is to create a new immunological balance that prevents rejection and does not promote opportunistic infection. Torque teno virus (TTV) ubiquitous non-pathogenic single-stranded DNA has been proposed as marker functional immunity in immunocompromised patients. Here investigate whether TTV loads predict the risk common viral infection allograft kidney recipients. In retrospective cohort 389 recipients,...