A5076628732- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Antiplatelet Therapy and Cardiovascular Diseases
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neural Engineering
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Neurological disorders and treatments
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2015-2025
Amsterdam UMC Location University of Amsterdam
2015-2024
University Medical Center
2022-2024
Amsterdam Neuroscience
2021-2024
Thrombolysis in Myocardial Infarction Study Group
2024
Vrije Universiteit Amsterdam
2012-2023
Amsterdam University of Applied Sciences
2023
Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023
University Hospital Bonn
2023
The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown.A BS patient without clinically detected cardiac structural abnormalities underwent transplantation for intolerable numbers implantable cardioverter/defibrillator discharges. patient's explanted heart was studied electrophysiologically histopathologically. Whole-cell currents were measured HEK293 cells expressing wild-type or mutated sodium channels from the patient. right ventricular outflow tract...
The subcutaneous implantable cardioverter-defibrillator (ICD) was designed to avoid complications related the transvenous ICD lead by using an entirely extrathoracic placement. Evidence comparing these systems has been based primarily on observational studies.We conducted a noninferiority trial in which patients with indication for but no pacing were assigned receive or ICD. primary end point composite of device-related and inappropriate shocks; margin upper boundary 95% confidence interval...
Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim this study was to determine the adult CHD population at risk SCD and clinical parameters associated SCD.We performed multicenter case-control study. Patients who died suddenly as result proven or presumed arrhythmia were included (cases). For each case, 2 controls matched on diagnosis, type surgical intervention, age, gender included. From 3 databases including 25 790 CHD, 1189...
Conventional cardiac pacemakers are associated with several potential short- and long-term complications related to either the transvenous lead or subcutaneous pulse generator. We tested safety clinical performance of a novel, completely self-contained leadless pacemaker.The primary end point was freedom from at 90 days. Secondary points included implant success rate, time, measures device (pacing/sensing thresholds rate-responsive performance). The mean age patient cohort (n=33) 77±8 years,...
Device-detected atrial high-rate episodes (AHREs) are arrhythmias detected by implanted cardiac devices. AHREs resemble fibrillation but rare and brief. Whether the occurrence of in patients without (as documented on a conventional electrocardiogram [ECG]) justifies initiation anticoagulants is not known. Download PDF Research Summary. We conducted an event-driven, double-blind, double-dummy, randomized trial involving 65 years age or older who had lasting for at least 6 minutes one...
Abstract Aims The concept of “atrial cardiomyopathy” (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using term were sporadic until decision was made to convene an expert working group with representation from four multinational arrhythmia organizations prepare a consensus document on atrial cardiomyopathy 2016 (EHRA/HRS/APHRS/SOLAECE cardiomyopathies: definition, characterization, and clinical implication). Subsequently, AtCM have...
Background — Progressive activation delay starting at long coupling intervals of premature stimuli has been shown to correlate with sudden cardiac death in patients hypertrophic cardiomyopathy. The purpose this study was elucidate the mechanism increased chronically diseased myocardium. Methods and Results High-resolution unipolar mapping (105, 208, or 247 recording sites interelectrode distances 0.8, 0.5, 0.3 mm, respectively) epicardial electrical activity carried out during stimulation 11...
Background— Thoracoscopic pulmonary vein isolation (PVI) and ganglionated plexus ablation is a novel approach in the treatment of atrial fibrillation (AF). We hypothesize that meticulous electrophysiological confirmation PVI results fewer recurrences AF during follow-up. Methods Results— Surgery was performed through 3 ports bilaterally. Ganglionated plexi were localized subsequently ablated. entry exit block confirmed. Additional left lines created conduction verified patients with...
Implantable cardioverter-defibrillators (ICDs) are widely used to prevent fatal outcomes associated with life-threatening arrhythmic episodes in a variety of cardiac diseases. These ICDs rely on transvenous leads for sensing and defibrillation. A new entirely subcutaneous ICD overcomes problems leads. However, the role as an adjunctive or primary therapy patients at risk sudden death is unclear. The PRAETORIAN trial investigator-initiated, randomized, controlled, multicenter, prospective...
The subcutaneous cardioverter-defibrillator (S-ICD) relies on a pre-implantation QRS-T morphology screening (TMS) of the ECG to assure that it reliably detects QRS complexes and T waves. prevalence clinical characteristics patients who fail this TMS is unknown.QRS-TMS was done in 230 consecutive ICD outpatients (75% male, age 57 ± 15 years) without an indication for cardiac pacing, using simulating 3 sensing vectors S-ICD (TMS-ECG). Patients were defined suitable when at least 1 vector...
Background— Atrial fibrosis is an important component of the arrhythmogenic substrate in patients with atrial fibrillation (AF). We studied effect interstitial on conduction velocity (CV) left appendage AF. Methods and Results— Thirty-five appendages were obtained during AF surgery. Preparations superfused stimulated at 100 beats per minute. Activation was recorded optical mapping. Longitudinal CV (CV L ), transverse T activation times (>2 mm distance) measured. Interstitial collagen...
Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable effectiveness not known. Recent data suggested that paired like homeodomain-2 transcription factor (PITX2) might play an important role in regulating gene expression and electrical function of adult left atrium (LA). After determining LA PITX2 AF requiring rhythm control therapy, authors assessed effects Pitx2c on electrophysiology effect antiarrhythmic drugs....
Abstract The ability to record and analyse electrical behaviour across the heart using optical electrode mapping has revolutionised cardiac research. However, wider uptake of these technologies is constrained by lack multi-functional robustly characterised analysis software. We present ElectroMap, an adaptable, high-throughput, open-source software for processing, complex electrophysiology datasets from diverse experimental models acquisition modalities. Key innovation development standalone...