A5016173778- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Electrostatic Discharge in Electronics
- Microbial Inactivation Methods
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Function and Risk Factors
- Electrohydrodynamics and Fluid Dynamics
- Heart Rate Variability and Autonomic Control
- Laser Design and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Laser-induced spectroscopy and plasma
- Pericarditis and Cardiac Tamponade
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
Icahn School of Medicine at Mount Sinai
2014-2024
Mount Sinai Hospital
2016-2024
Na Homolce Hospital
2014-2023
Washington Hospital
2023
MedStar Georgetown University Hospital
2023
Georgetown University
2023
Mount Sinai Hospital
2021-2023
Stroke Association
2021-2023
Massachusetts General Hospital
2011-2022
Mount Sinai Hospital
2011-2021
Catheter ablation of atrial fibrillation using thermal energies such as radiofrequency or cryothermy is associated with indiscriminate tissue destruction. During pulsed field (PFA), subsecond electric fields create microscopic pores in cell membranes-a process called electroporation. Among types, cardiomyocytes have among the lowest thresholds to these fields, potentially permitting preferential myocardial ablation.The purpose 2 trials was determine whether PFA allows durable pulmonary vein...
This study sought to determine whether durable pulmonary vein isolation (PVI) using pulsed field ablation (PFA) translates freedom from atrial fibrillation recurrence without an increase in adverse events.PFA is a nonthermal ablative modality that, preclinical studies, able preferentially ablate myocardial tissue with minimal effect on surrounding tissues. Herein, we present 1-year clinical outcomes of PFA.In 3 multicenter studies (IMPULSE [A Safety and Feasibility Study the IOWA Approach...
Conventional cardiac pacemakers are associated with several potential short- and long-term complications related to either the transvenous lead or subcutaneous pulse generator. We tested safety clinical performance of a novel, completely self-contained leadless pacemaker.The primary end point was freedom from at 90 days. Secondary points included implant success rate, time, measures device (pacing/sensing thresholds rate-responsive performance). The mean age patient cohort (n=33) 77±8 years,...
Unlike for paroxysmal atrial fibrillation (AF), pulmonary vein isolation (PVI) alone is considered insufficient many patients with persistent AF. Adjunctive ablation of the left posterior wall (LAPW) may improve outcomes, but limited by both difficulty achieving lesion durability and concerns damage to esophagus-situated behind LAPW.This study sought assess safety pulsed field (PFA) PVI LAPW in AF.PersAFOne a single-arm evaluating biphasic, bipolar PFA using multispline catheter under...
Patients with ischemic stroke attributed to large- or small-vessel disease are not considered at high risk for atrial fibrillation (AF), and the AF incidence rate in this population is unknown.To determine whether long-term cardiac monitoring more effective than usual care detection patients through 12 months of follow-up.The STROKE-AF trial was a randomized (1:1), multicenter (33 sites US) clinical that enrolled 496 between April 2016 July 2019, primary end point follow-up August 2020....
Pulsed field ablation (PFA) can be myocardium selective, potentially sparing the esophagus during left atrial ablation. In an in vivo porcine esophageal injury model, we compared effects of newer biphasic PFA with radiofrequency (RFA).
Background: Pulsed field ablation (PFA) is a uniquely tissue-selective, nonthermal cardiac modality. Delivery parameters such as the electrical waveform composition and device design are critical to PFA’s efficacy safety, particularly tissue specificity. In series of preclinical studies, we sought examine electrophysiological histological effects PFA compare safety feasibility durable pulmonary vein superior vena cava (SVC) isolation between radiofrequency waveforms. Methods: A femoral...
Background: The tissue selectivity of pulsed field ablation (PFA) provides safety advantages over radiofrequency in treating atrial fibrillation. One-shot PFA catheters have been shown capable performing pulmonary vein isolation, but not flexible lesion sets such as linear lesions. A novel lattice-tip catheter with a compressible 9-mm nitinol tip is able to deliver either focal or lesions, each 2 5 s. Methods: In 3-center, single-arm, first-in-human trial, the 7.5F lattice was used custom...
Because of its safety, "single-shot" pulsed field ablation (PFA) catheters have been developed for pulmonary vein isolation (PVI). However, most atrial fibrillation (AF) procedures are performed with focal to permit flexibility lesion sets beyond PVI.This study sought determine the safety and efficacy a catheter able toggle between radiofrequency (RFA) or PFA treat paroxysmal persistent AF.In first-in-human study, 9-mm lattice tip was used posteriorly either irrigated RFA (RF/PF) (PF/PF)...
The ADVENT randomized trial revealed no significant difference in 1-year freedom from atrial arrhythmias (AA) between thermal (radiofrequency/cryoballoon) and pulsed field ablation (PFA). However, recent studies indicate that the postablation AA burden is a better predictor of clinical outcomes than dichotomous endpoint 30-second recurrence. goal this study was to determine: 1) impact on outcomes; 2) effect modality burden. In ADVENT, symptomatic drug-refractory patients with paroxysmal...
Catheter ablation is effective for eliminating most drug-refractory ventricular arrhythmias (VA). However, a major reason procedural failure arrhythmia originating deep within the myocardium where it inaccessible to conventional endocardial or epicardial approaches. Affected patients have limited therapeutic options.The objective of this study was assess safety and outcome novel radiofrequency catheter that used an extendable/retractable 27-g needle capable targeting (intramural)...
Percutaneous left ventricular assist devices (pLVADs) are increasingly being used to facilitate ablation of unstable tachycardia (VT), but the safety profile and hemodynamic benefits these have not been described in a systematic, prospective manner.Twenty patients with scar VT underwent pLVAD. Neuromonitoring using cerebral oximetry was performed evaluate desaturation threshold guide duration activation/entrainment mapping. The efficacy pLVAD support tested controlled manner simulated VT....
Pulsed field ablation (PFA) is a novel, non-thermal modality that selectively ablates myocardium with ultra-short electrical impulses while sparing collateral tissues. In proof-of-concept study, the safety and feasibility of ventricular PFA were assessed using prototype steerable, endocardial catheter.
Patients with coronavirus disease 2019 (COVID-19) who develop cardiac injury are reported to experience higher rates of malignant arrhythmias. However, little is known about these arrhythmias-their frequency, the underlying mechanisms, and their impact on mortality.