A5044812196- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- RNA modifications and cancer
- Cardiovascular Syncope and Autonomic Disorders
- Blood Pressure and Hypertension Studies
- Acute Ischemic Stroke Management
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Heart Rate Variability and Autonomic Control
- DNA Repair Mechanisms
- Cardiac Arrhythmias and Treatments
- Lung Cancer Treatments and Mutations
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Effects of Radiation Exposure
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Healthcare Technology and Patient Monitoring
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- NF-κB Signaling Pathways
- Bladder and Urothelial Cancer Treatments
- Cardiovascular Function and Risk Factors
- Cancer-related Molecular Pathways
Medtronic (United States)
2015-2025
San Francisco General Hospital
2024
University of California, San Francisco
2024
Universidad Santiago de Cali
2018
Lovelace Respiratory Research Institute
2011-2014
Johns Hopkins University
2011-2014
Sidney Kimmel Comprehensive Cancer Center
2010-2014
Shinshu University
2014
Ghent University
2014
National Cancer Institute
2011
Epigenetic alterations are strongly associated with the development of cancer. We conducted a phase I/II trial combined epigenetic therapy azacitidine and entinostat, inhibitors DNA methylation histone deacetylation, respectively, in extensively pretreated patients recurrent metastatic non-small cell lung This is well tolerated, objective responses were observed, including complete response partial patient who remains alive without disease progression approximately 2 years after completing...
Patients with ischemic stroke attributed to large- or small-vessel disease are not considered at high risk for atrial fibrillation (AF), and the AF incidence rate in this population is unknown.To determine whether long-term cardiac monitoring more effective than usual care detection patients through 12 months of follow-up.The STROKE-AF trial was a randomized (1:1), multicenter (33 sites US) clinical that enrolled 496 between April 2016 July 2019, primary end point follow-up August 2020....
Franco, N., Lamartine, J., Frouin, V., Le Minter, P., Petat, C., Leplat, J.-J., Libert, F., Gidrol, X. and Martin, M. T. Low-Dose Exposure to γ Rays Induces Specific Gene Regulations in Normal Human Keratinocytes. Radiat. Res. 163, 623–635 (2005).Skin is the organ most exposed various environmental aggressors, including ionizing radiation. Low-dose low-dose-rate exposures rays account for occupational, medical or irradiations. To examine whether this type of exposure triggers specific...
Background Insertable cardiac monitors (ICMs) are used to continuously monitor the patient's electrocardiogram. In response patient activation or based on automated device algorithms, arrhythmia episodes stored and automatically transmitted daily clinician. Thus, ICMs can be diagnose arrhythmias in at-risk patients those with symptoms potentially attributable arrhythmias. The ICM described this report has undergone a dramatic change size method of insertion. Methods To evaluate safety...
The STROKE AF study found that in patients with prior ischemic stroke attributed to large-artery atherosclerotic disease (LAD) or small-vessel occlusive (SVD), 12% developed over 1 year when monitored an insertable cardiac monitor (ICM). occurrence subsequent years is unknown.
Abstract Introduction The increasing use of insertable cardiac monitors (ICMs) for long‐term continuous arrhythmia monitoring creates a high volume transmissions and significant workload clinics. ability to remotely reprogram device alert settings without in‐office patient visits was recently introduced, but its impact on clinic workflow compared the previous ICM iteration is unknown. Methods aim this real‐world study evaluate reprogramming capabilities burden workflow. Deidentified data...
Introduction: Prior studies have shown various sex disparities in stroke care; whether exist for cardiac consultation or monitoring post-stroke is unknown. Methods: DiVERT (SeconDary Stroke PreVEntion ThRough Pathway ManagemenT) an ongoing, retrospective, multicenter study evaluating in-hospital care pathways patients with cryptogenic, large-vessel atherosclerotic disease and small vessel subtypes. Phase I included in-person clinician interviews across cardiology vascular neurology...
SUMMARY Objectives: The aim of this study was to compare the bleaching efficacy and tooth sensitivity (TS) a 38% hydrogen peroxide agent used for in-office bleaching, applied under different time protocols: 40-minute application or two 20-minute applications. Methods Materials: Forty-four patients from Brazil Colombia, with right superior canines darker than C2, were selected multicenter, single-blind, randomized trial. teeth bleached in sessions, one-week interval between them, split-mouth...
The Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE AF) trial found that approximately 1 in 8 patients with recent ischemic stroke attributed to large- or small-vessel disease had poststroke atrial fibrillation (AF) detected by an insertable cardiac monitor (ICM) at 12 months. Identifying predictors AF could be useful when considering ICM routine clinical care.To determine the association between commonly assessed risk factors detection new STROKE cohort monitored ICM.This...
Introduction: Identification of atrial fibrillation (AF) in patients with stroke is critical for secondary prevention guideline-recommended oral anticoagulation (OAC). The randomized STROKE AF trial evaluating ischemic attributed to large-artery or small-vessel disease (LAD/SVD) found that insertable cardiac monitors (ICMs) were more likely detect than standard care (SoC) using intermittent external ECG monitors. However, the cost-effectiveness ICMs this population not known. This study...
Abstract Aims We aim to evaluate the incidence of atrial fibrillation (AF) in a large real‐world cohort patients implanted with an insertable cardiac monitor (ICM) who had clinical history symptomatic heart failure (HF) reduced or preserved left ventricular ejection fraction (LVEF). Methods Patients ICM and HF events were identified from Optum® de‐identified Electronic Health Record dataset merged device collected during 2007–2021. All ICM‐detected AF episodes that available ≥30‐s ECG at...
We performed a microarray study on human differentiated HaCaT keratinocytes exposed to ionizing radiation (2 or 10 Gy). At 3 h after exposure, more than 150 known and unknown genes were found regulated in irradiated keratinocytes. Among the at h, those involved cell energy metabolism appeared be most abundant responsive. Two mitochondrial ATP-synthases several other producing pathways, such as glucose metabolism, induced, whereas many from requiring pathways shut down. These changes...
<h3>Hypothesis</h3> The cause of breast cancer is linked to many macroscopic events, including benign disease. In this study we asked whether molecular changes could discriminate fibroadenoma, which one the most common disease lesions associated or not with cancer. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> Anticancer medical center. <h3>Subjects</h3> Archival tissues in 32 cases diagnosed same as a carcinoma, are compared control group 26 fibroadenomas unaffected by...
Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation. Because human skin constantly renews itself is first target of irradiation, it primary interest to evaluate whether such gene may be regulated keratinocytes exposed ionizing radiation. We show here that induced response γ-irradiation have investigated consequence this regulation on fate. Using RNA interference, we observed extinction significantly reduces growth through control G1-S...
Background The use of prophylactic antibiotics during insertable cardiac monitor (ICM) procedures is a carryover the common practice used with therapeutic implantable electronic devices. We sought to characterize current ICM insertion evaluate influence antibiotic administration on occurrence infections. Methods characterized and procedure‐related infections from an ongoing multicenter registry (Reveal LINQ TM Registry). In order accurately capture infections, only patients enrolled before...