A5072674515- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Central Venous Catheters and Hemodialysis
- Mechanical Circulatory Support Devices
- Connective tissue disorders research
- Neurological disorders and treatments
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Protease and Inhibitor Mechanisms
- Infective Endocarditis Diagnosis and Management
- Vascular Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Vector-Borne Animal Diseases
- Neurogenetic and Muscular Disorders Research
- T-cell and Retrovirus Studies
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Radiation Dose and Imaging
MedStar Heart & Vascular Institute
2019-2025
MedStar Washington Hospital Center
2012-2024
MedStar Health
2017-2022
Washington Hospital
2021
Georgetown University
2011-2021
MedStar Georgetown University Hospital
2017
Johns Hopkins University
1995-2015
Virginia Commonwealth University Medical Center
2014
University of Maryland, Baltimore
2014
Johns Hopkins Medicine
1995-2005
Infections after placement of cardiac implantable electronic devices (CIEDs) are associated with substantial morbidity and mortality. There is limited evidence on prophylactic strategies, other than the use preoperative antibiotics, to prevent such infections.
The ADVENT randomized trial revealed no significant difference in 1-year freedom from atrial arrhythmias (AA) between thermal (radiofrequency/cryoballoon) and pulsed field ablation (PFA). However, recent studies indicate that the postablation AA burden is a better predictor of clinical outcomes than dichotomous endpoint 30-second recurrence. goal this study was to determine: 1) impact on outcomes; 2) effect modality burden. In ADVENT, symptomatic drug-refractory patients with paroxysmal...
The purpose of this study was to determine the radiation exposure during catheter ablation atrial fibrillation (AF) using pulmonary vein (PV) approach.The included 15 patients with AF and 5 each flutter atrioventricular nodal reentrant tachycardia (AVNRT) who underwent fluoroscopically guided procedures on a biplane x-ray system operated at low-frame pulsed fluoroscopy (7.5 frames per second). Radiation measured directly 50 60 thermoluminescent dosimeters (TLDs). Peak skin doses (PSDs),...
Introduction: There are currently no studies systematically evaluating pulmonary vein (PV) stenosis following catheter ablation of atrial fibrillation (AF) using the anatomic PV approach. Methods and Results: Forty‐one patients with AF underwent under guidance a three‐dimensional electroanatomic mapping system. Gadolinium‐enhanced magnetic resonance (MR) imaging was performed in all prior to 8–10 weeks after procedures for screening stenosis. A defined as detectable (≥3 mm) narrowing...
Introduction: The aims of this study were to identify predictors recurrence after catheter ablation atrial fibrillation (AF) and report the safety efficacy AF using an irrigated‐tip catheter. Methods Results: Seventy‐five consecutive patients (51 men [68%]; age 54 ± 13 years) with symptomatic drug‐refractory paroxysmal (42 patients), persistent (21 or permanent (12 patients) underwent a standard strategy, which involved electrical isolation all pulmonary veins (PVs) creation cavotricuspid...
This study compared the efficacy and safety of VASCADE MVP Venous Vascular Closure System (VVCS) device (Cardiva Medical, Santa Clara, California) to manual compression (MC) for closing multiple access sites after catheter-based electrophysiology procedures.The VVCS is designed provide earlier ambulatory hemostasis than MC AMBULATE (A Randomized, Multi-center Trial Compare Cardiva Mid-Bore [VASCADE MVP] Manual Compression in Multiple Femoral Access Sites 6 - 12 Fr Sheath Sizes) trial was a...
Background: In the WRAP-IT trial (Worldwide Randomized Antibiotic Envelope Infection Prevention), adjunctive use of an absorbable antibacterial envelope resulted in a 40% reduction major cardiac implantable electronic device infection without increased risk complication 6983 patients undergoing revision, replacement, upgrade, or initial resynchronization therapy defibrillator implant. There is limited information on cost-effectiveness this strategy. As prespecified objective, we evaluated...
FBN1 encodes fibrillin-1, an extracellular matrix protein that is defective in Marfan syndrome. This gene divided into 65 exons and was previously reported to be approximately 110 kb length. The existence of 3 upstream the exon containing putative initiating methionine left open possibility alternative fibrillin-1 isoforms vary at their N-termini. Detailed examination YACs human reveal 200 kb, almost twice as large thought. Characterization porcine cDNA 5' flanking sequence demonstrates...
The Marfan syndrome (MFS) is a connective tissue disorder inherited as an autosomal dominant trait and caused by mutations in the gene encoding fibrillin, 350-kD glycoprotein that multimerizes to form extracellular microfibrils. It has been unclear whether disease results from relative deficiency of wild-type fibrillin; dominant-negative effect, which mutant fibrillin monomers disrupt function protein encoded normal allele; or dynamic variable interplay between these two pathogenetic...
Abstract RNA sequences of five flaviviruses were detected by a modified polymerase chain reaction (PCR) that incorporated reverse transcriptase and RNase inhibitor. Oligonucleotide primer pairs synthesized to amplify from St. Louis encephalitis (SLE), Japanese (JBE), yellow fever (YF), dengue 2 (DEN‐2), 4 (DEN‐4) viruses. The amplified products visualized as bands appropriate size on ethidium bromide‐stained agarose gels. identity these was confirmed restriction endonuclease cleavage...
Background— Primary prevention implantable cardioverter defibrillators (ICDs) reduce all-cause mortality, but the benefits are heterogeneous. Current risk stratification based on left ventricular ejection fraction has limited discrimination power. We hypothesize that biomarkers for inflammation, neurohumoral activation, and cardiac injury can predict appropriate shocks mortality in patients with primary ICDs. Methods Results— The Prospective Observational Study of Implantable Cardioverter...
Background Primary‐prevention implantable cardioverter‐defibrillators ( ICDs ) reduce total mortality in patients with severe left ventricular systolic function. However, only a minority of benefit from these devices. We designed the Prospective Observational Study Implantable Cardioverter‐Defibrillators PROSE ‐ ICD to identify risk factors and enhance our understanding biological mechanisms that predispose arrhythmic death undergoing implantation for primary prevention sudden death. Methods...
The polymerase chain reaction (PCR) was modified to detect RNA genomic sequences by generating cDNA copies of these as a preliminary step. Oligonucleotide primer pairs complementary in each the five major structural protein genes measles virus (nucleocapsid protein, phosphoprotein, matrix fusion and hemagglutinin protein) were synthesized. PCR products tentatively identified visualization bands appropriate size ethidium bromide staining after gel electrophoresis, identity confirmed...
Sera collected from 1,102 individuals in 14 populations of the southwestern Pacific between 1956 and 1979 were tested by ELISA for antibodies to human T-cell leukemia virus type I (HTLV-I). Selected sera also particle agglutination immunoblotting. Six had prevalences greater than 4%, two 15%. antibody 2% or less. Three coast northern islands New Guinea high antibodies, while three highland groups virtually none. One population Solomon Islands a prevalence, others very low prevalences. Two...