A5100671812- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Colorectal Cancer Surgical Treatments
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Colorectal and Anal Carcinomas
- Cerebrovascular and Carotid Artery Diseases
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Mitochondrial Function and Pathology
- ECG Monitoring and Analysis
- Sodium Intake and Health
Columbia University Irving Medical Center
2018-2025
Columbia University
2017-2025
Shanghai University of Traditional Chinese Medicine
2011-2024
First Affiliated Hospital of Fujian Medical University
2020-2024
Fujian Medical University
2017-2024
University of Electronic Science and Technology of China
2023-2024
Westlake University
2023-2024
GTx (United States)
2024
Zhejiang University
2023-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2011-2024
Overall hypertension prevalence has not changed in the United States recent decades although awareness, treatment, and control improved. However, epidemiology its temporal trends may differ younger adults compared with older adults. Our study included 41 331 participants ≥18 years of age from 8 National Health Nutrition Examination Surveys (1999-2014) estimated hypertension, among young (age, 18-39 years) middle-age 40-59 ≥60 years). In 2013 to 2014, 7.3% US had hypertension. During 1999 saw...
Background: The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored. Objective: To investigate the incident CKD across categories of body mass index in a large cohort men and women. Design: Prospective study. Setting: Kangbuk Samsung Health Study, Hospital, Seoul, South Korea. Participants: 62 249 healthy, young middle-aged women or proteinuria at baseline. Measurements:...
Mitochondrial dysfunction is a core component of the aging process and may play key role in atherosclerotic cardiovascular disease. DNA copy number (mtDNA-CN), which represents mitochondria per cell mitochondrial genomes mitochondrion, an indirect biomarker function.To determine whether mtDNA-CN, measured easily accessible tissue (buffy coat/circulating leukocytes), can improve risk classification for disease (CVD) help guide initiation statin therapy primary prevention CVD.Prospective,...
Blood pressure (BP) and cholesterol are major modifiable risk factors for cardiovascular disease (CVD), but effects of exposures during young adulthood on later life CVD have not been well quantified. The authors sought to evaluate the independent associations between adult risk, accounting exposures. pooled data from 6 U.S. cohorts with observations spanning course life, imputed factor trajectories low-density lipoprotein (LDL) high-density cholesterols, systolic diastolic BP starting age...
The risk of nonalcoholic fatty liver disease (NAFLD) among obese individuals without obesity-related metabolic abnormalities, a condition referred to as metabolically healthy (MHO), is largely unexplored. Therefore, we examined the association between body mass index (BMI) categories and development NAFLD in large cohort men women.A study was conducted 77,425 women free abnormalities at baseline, who were followed-up annually or biennially for an average 4.5 years. Being defined not having...
Background and Purpose— Preliminary studies suggest that intracranial arteries are capable of accommodating plaque formation by remodeling. We sought to study the ability extent remodel using 3-dimensional high-resolution black blood magnetic resonance imaging investigate its relation ischemic events. Methods— Forty-two patients with cerebrovascular events underwent time-of-flight angiography contrast-enhanced examinations at 3 T for atherosclerotic disease. Each was classified location (eg,...
Low-density lipoprotein cholesterol (LDL-C) is a major risk factor for cardiovascular disease (CVD). Most observational studies on the association between LDL-C and CVD have focused level at single time point (usually in middle or older age), few characterized long-term exposures to their role risk.To evaluate associations of cumulative exposure LDL-C, time-weighted average (TWA) slope change during young adulthood age with incident later life.This cohort study analyzed pooled data from 4...
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of injury is uncertain. Objective To describe relationship between imaging estimates irreversibly injured brain (core) at-risk regions (mismatch) clinical outcomes EVT treatment effect. Design, Setting, Participants An exploratory analysis SELECT2 trial, which randomized 352 adults (18-85 years) due to occlusion internal carotid or middle cerebral...
Background: Blacks have a higher incidence of out-of-hospital sudden cardiac death (SCD) in comparison with whites. However, the racial differences cumulative risk SCD and reasons for these not been assessed large-scale community-based cohorts. The objective this study is to compare lifetime among blacks whites, evaluate factors that may explain general population. Methods: This cohort 3832 11 237 whites participating Atherosclerosis Risk Communities Study (ARIC). Race was self-reported....
Background and Purpose— Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, but little known about its epidemiology. We studied the prevalence ICAS association with vascular risk factors using high-resolution magnetic resonance angiography in US cardiovascular cohort. Methods— The Atherosclerosis Risk Communities (ARIC) study recruited participants from 4 communities 1987 to 1989. Using stratified sampling, we selected 1980 visit 5 (2011–2013) for 3T-magnetic...
To evaluate the association between diabetes mellitus (DM) and development of incident hearing loss.Prospective cohort study was performed in 253 301 adults with normal tests who participated a regular health-screening exam 2002 2014. The main exposure presence DM at baseline, defined as fasting serum glucose ≥ 126 mg/dL, self-reported history or current use anti-diabetic medications. Pre-diabetes 100-125 mg/dL no medication use. Incident loss pure-tone average thresholds 0.5, 1.0 2.0 kHz >...
Abstract Berberine, a natural compound extracted from several Chinese herbs including Coptis chinensis, has been shown to have anti-obesity effects and prevents insulin resistance in high-fat diet (HFD)-fed obese rats by modulating the gut microbiota; however, molecular mechanisms underlying these activities remain unknown. We investigated of berberine on obesity examining lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/tumor necrosis factor (TNF)-α signaling pathway livers HFD-fed...
Purpose To implement a magnetic resonance (MR) imaging protocol to measure intracranial atherosclerotic disease (ICAD) in population-based multicenter study and report examination reader reliability of these MR measurements descriptive statistics representative the general population. Materials Methods This prospective was approved by institutional review boards compliant with HIPAA. Atherosclerosis Risk Communities (ARIC) participants (n = 1980) underwent brain from 2011 2013 at four ARIC...
To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia.From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from population-based Atherosclerosis Risk in Communities Study by a sampling strategy that allowed weighting back cohort. We defined ICAD plaque features (presence, territory, stenosis, number). Trained clinicians used an algorithm incorporating information interviews neuropsychological...
The COVID-19 pandemic may have negatively affected medical care for and self-management of chronic hypertension. We sought to examine the impact on blood pressure (BP) among individuals with hypertension.Using an interrupted time series analysis, we compared level trend (slope) BP outcomes before public health emergency declaration (prepandemic period: August 2018 through January 2020) versus after stay-at-home orders (pandemic April 2020 November adults hypertension followed at 3 large...
Young adults may have high long-term atherosclerotic cardiovascular disease (ASCVD) risk despite low short-term risk. In this study, we sought to compare the performance of and ASCVD prediction tools in young evaluate incidence associated with predicted We included aged 18 39 years, from 2008 2009 a U.S. integrated health care system, followed them through 2019. calculated 10-year 30-year assessed incidence. Among 414,260 adults, 813 had an incident event during median 4 years (maximum 11...
The benefit of adding social determinants health (SDOH) when estimating atherosclerotic cardiovascular disease (ASCVD) risk is unclear.
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).