A5101923306- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Traumatic Brain Injury Research
- Thermal Regulation in Medicine
- EEG and Brain-Computer Interfaces
- Metastasis and carcinoma case studies
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Analytical chemistry methods development
- Innovations in Medical Education
- Congenital Diaphragmatic Hernia Studies
- Neurosurgical Procedures and Complications
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Ear Surgery and Otitis Media
- Cardiac electrophysiology and arrhythmias
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Ion channel regulation and function
- Respiratory Support and Mechanisms
- Liver Disease and Transplantation
University Hospitals of Cleveland
2017-2025
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Case Western Reserve University
2010-2024
University of British Columbia
2013-2024
University of British Columbia Hospital
2023
University School
2015-2022
St. Paul's Hospital
2022
Memorial Health System
2021
Jackson Memorial Hospital
2021
We report a high performance oxygen reduction reaction (ORR) catalyst based on vertically aligned, nitrogen-doped carbon nanotube (VA-NCNT) arrays. Characterization in conditions analogous to the operation of polymer electrolyte membrane fuel cell show ORR taking place at favorable potential with superior current density and greater rate constant.
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of injury is uncertain. Objective To describe relationship between imaging estimates irreversibly injured brain (core) at-risk regions (mismatch) clinical outcomes EVT treatment effect. Design, Setting, Participants An exploratory analysis SELECT2 trial, which randomized 352 adults (18-85 years) due to occlusion internal carotid or middle cerebral...
Heart failure (HF) is characterized by marked prolongation of action potential duration and reduction in cellular repolarization reserve. These changes are caused large part HF-induced K(+) current downregulation. Molecular mechanisms underlying these remain unclear. We determined whether downregulation currents a canine model tachycardia-induced HF altered expression channel alpha- beta-subunits encoding currents. subunit was quantified normal failing dogs at the mRNA protein levels...
Spatial electrical heterogeneity has a profound effect on normal cardiac electrophysiology and genesis of arrhythmias in diseased hearts. The Na + –Ca 2+ exchanger (NCX) is key linker, through Ca signaling, between contractility arrhythmias. Here we characterize the differential transmural expression NCX rapid pacing-induced failing canine Significant was present hearts, as current density measured at +80 mV significantly ( P <0.05) greater epicardial (EPI) (5.49 pA/pF) than...
Introduction: For patients transferred for EVT considerations, direct-to-angio approach is shown to reduce time procedure and improve clinical outcomes. We aimed assess if IV thrombolytics status prior transfer modifies the association between improved outcomes in who received EVT. Methods: In a secondary analysis of retrospective cohort from 6 centers across US Europe, were stratified based on thrombolytic status. Association vs repeated imaging with functional was assessed among without...
High incidence of poor neurologic sequelae after resuscitation from cardiac arrest underscores the need for objective electrophysiological markers assessment and prognosis. This study aims to develop a novel marker based on somatosensory evoked potentials (SSEPs). Normal SSEPs involve thalamocortical circuits suggested play role in arousal. Due vulnerability these hypoxic-ischemic insults, we hypothesize that quantitative SSEP may indicate future status.Laboratory investigation.University...
Temperature fluctuations significantly impact neurological injuries in intensive care units. As the benefits of therapeutic hypothermia continue to unfold, many these discoveries are generated by studies animal models undergoing experimental procedures under influence anesthetics. We studied effect induced on neural electrophysiological signals an uninjured brain a rodent model while isoflurane. Fourteen rats were divided into 2 groups (n=7 each), basis electrode placement at either...
Evoked potentials recorded from the somatosensory cortex have been shown to be an electrophysiological marker of brain injury in global hypoxic ischemia (HI). The evoked responses neurons carry information pertaining signal ascending pathway both subcortical and cortical areas. In this study, origins signals are explored by decomposing neuronal activities into short- long-latency (SLR LLR), respectively. We evaluated effect therapeutic hypothermia on SLR LLR during early recovery cardiac...
Recent electrophysiological studies have suggested surges in electrical correlates of consciousness (i.e., elevated gamma power and connectivity) after cardiac arrest (CA). This study examines electrocorticogram (ECoG) activity coherence the dying brain during asphyxial CA. Male Wistar rats (n = 16) were induced with isoflurane anesthesia, which was washed out before Mean phase ECoG compared different stages period to assess potential neural consciousness. After asphyxia, progressed through...
To develop a risk prediction score identifying patients with intracerebral hemorrhage (ICH) at low for critical care.We retrospectively analyzed data of 451 ICH between 2010 and 2018. The sample was randomly divided into development validation cohort. Logistic regression used to by weighting independent predictors intensive care unit (ICU) needs according strength association. tested in the cohort externally validated dataset from another institution.The rate ICU interventions 80.3%....
Endovascular thrombectomy (EVT) safety and efficacy in patients with large core infarcts receiving oral anticoagulants (OAC) are unknown. In the SELECT2 trial (NCT03876457), 29 of 180 (16%; vitamin K antagonists 15, direct OACs 14) EVT, 18 172 (10%; 3, 15) medical management (MM) reported OAC use at baseline. EVT was not associated better clinical outcomes group (EVT 6 [4-6] vs MM 5 [4-6], adjusted generalized odds ratio 0.89 [0.53-1.50]), but demonstrated significantly without 4 [3-6] 1.87...
High-grade neuroendocrine carcinoma (HGNEC) is subclassified into small cell (SmCC) and large (LCNEC). Although both are clinically aggressive, the SmCC LCNEC need to have different treatment strategies, accurate pathologic diagnosis challenging. We studied a retrospective cohort (186 cases) of HGNEC bladder lung investigate abundance cytokeratin (CK) 7 expression staining pattern in LCNEC. Overall, pulmonary urinary exhibited several CK7 patterns, including negative (n=28), dot-like (n=73),...
OPEN ACCESSOctober 16, 2020An Interactive Approach to Teaching the Clinical Applications of Autonomy and Justice in Context Discharge Decision-Making Divya Palanisamy, Wei Xiong, MD Palanisamy Fourth-Year Medical Student, Case Western Reserve University School Medicine E-mail Address: [email protected] , Assistant Dean for Clerkship Education, Medicine; Core Director Professor, Department Neurology, Hospitals Cleveland Center https://doi.org/10.15766/mep_2374-8265.10992...
Near the beginning of COVID-19 pandemic in United States, medical students were pulled out all in-person patient care activities. This resulted massive disruption to required clinical rotations (clerkships), necessitating creative curricular solutions ensure continued education for students.In response lockout, our school adopted a "flipped" model that assigned remote learning activities prior approach allowed continue their virtually with focus on knowledge practice while awaiting return...