A5021442811- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Urinary Tract Infections Management
- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- Cancer Immunotherapy and Biomarkers
- Molecular Sensors and Ion Detection
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Cerebrovascular and genetic disorders
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Viral-associated cancers and disorders
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroscience and Neuropharmacology Research
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Human Pose and Action Recognition
- Neuroendocrine regulation and behavior
University of British Columbia
2016-2025
Bristol-Myers Squibb (Canada)
2024
Bayer (Canada)
2024
Kyushu University Hospital
2020
Medway School of Pharmacy
2014-2016
University of Copenhagen
2011
American Pharmacists Association
2010
Royal Veterinary College
2009
Abstract Investigation of histopathology slides by pathologists is an indispensable component the routine diagnosis cancer. Artificial intelligence (AI) has potential to enhance diagnostic accuracy, improve efficiency, and patient outcomes in clinical pathology. However, variations tissue preparation, staining protocols, slide digitization could result over-fitting deep learning models when trained on data from only one center, thereby underscoring necessity generalize networks for...
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 P2 receptors, to elicit a wide variety of physiological pathophysiological responses through paracrine autocrine signalling pathways. For the first time, we have used an ion-pair reversed-phase high-performance liquid chromatography ultraviolet (UV)-coupled method rapidly simultaneously quantify 12 different nucleotides (adenosine triphosphate, adenosine diphosphate, monophosphate,...
Platinum-based neoadjuvant chemotherapy prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer despite modest survival benefit and significant associated toxicities. Here, we profile global proteome of cancers pre- post-neoadjuvant using archival formalin-fixed paraffin-embedded tissue. We identify four pre-neoadjuvant proteomic clusters with distinct biology response therapy integrate these transcriptomic subtypes immunohistochemistry. observe plasticity...
Vasopressin regulates water reabsorption in the collecting duct, but extracellular nucleotides modulate this regulation through incompletely understood mechanisms. We investigated these mechanisms using immortalized mouse duct (mpkCCD) cells. Basolateral exposure to dDAVP induced AQP2 localization apical membrane, co-treatment with ATP internalized AQP2. Because plasma membrane-bound P2 receptors (P2R) mediate effects of nucleotides, we examined abundance and P2R mpkCCD In absence dDAVP,...
Overactive Bladder (OAB) is an idiopathic condition, characterized by urgency, urinary frequency, and urgency incontinence, in the absence of routinely traceable infection. We have described microscopic pyuria (≥10 wbc/μl) patients suffering from worst symptoms. It established that inflammation associated with increased ATP release epithelial cells, extracellular originating urothelium following hydrostatic pressure a mediator bladder sensation. Here, using biopsy samples, we investigated...
Cancer subtyping is one of the most challenging tasks in digital pathology, where Multiple Instance Learning (MIL) by processing gigapixel whole slide images (WSIs) has been spotlight recent research. However, MIL approaches do not take advantage inter- and intra-magnification information contained WSIs. In this work, we present GRASP, a novel graph-structured multi-magnification framework for WSIs pathology. Our approach designed to dynamically emulate pathologist's behavior handling...
In order to investigate the 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as a carboxylic acid bioisoster at ionotropic glutamate receptors (iGluRs), series of acidic α-aminocarboxylic acids in which distal carboxy group was replaced by synthesized. Ionization constants were determined. All target compounds, except Asp analogue 12, resolved using chiral HPLC. Whereas 12 showed good affinity exclusively NMDA receptors, Glu analogue, (+)-10, an unselective, though potent AMPA receptor preferring...
In order to map out molecular determinants for competitive blockade of AMPA receptor subtypes, a series 2-carboxyethylphenylalanine derivatives has been synthesized and pharmacologically characterized in vitro. One compound this series, (RS)-3h, showed micromolar affinity GluA1o GluA2(R)o receptors with an approximately 4-fold preference GluA1/2 vs GluA3/4. TEVC electrophysiological experiments (RS)-3h competitively antagonized GluA2(Q)i receptors. The X-ray structure the active enantiomer...
Paternally expressed gene 10 (PEG10) has been associated with neuroendocrine muscle-invasive bladder cancer (MIBC), a subtype of the disease poorest survival. In this work, we further characterized expression pattern PEG10 in The Cancer Genome Atlas database 412 patients MIBC, and found that, compared other subtypes, mRNA level was enhanced neuroendocrine-like MIBC highly correlated markers. protein also markers tissue microarray 82 cases. cell lines, induced drug-resistant parental cells,...
Abstract Renal transplant recipients (RTR) are highly susceptible to urinary tract infections (UTIs) with over 50% of patients having at least one UTI within the first year. Yet it is generally acknowledged that there considerable insensitivity and inaccuracy in routine urinalysis when screening for UTIs. Thus a large number genuine urine may go undiagnosed develop chronic recalcitrant infections, which can be associated graft loss morbidity. Given recent study demonstrating ATP released by...
Abstract Chemotherapy is a standard therapy for muscle-invasive bladder cancer (MIBC). However, genomic alterations associated with chemotherapy sensitivity in MIBC have not been fully explored. This study aimed to investigate the landscape of association response and explore biological role alterations. Genomic were sequenced by targeted exome sequencing 409 genes. Gene expression tissues was analyzed western blotting, immunohistochemistry, RNA microarray. Cellular gemcitabine metabolite...
High-grade neuroendocrine carcinoma (HGNEC) is subclassified into small cell (SmCC) and large (LCNEC). Although both are clinically aggressive, the SmCC LCNEC need to have different treatment strategies, accurate pathologic diagnosis challenging. We studied a retrospective cohort (186 cases) of HGNEC bladder lung investigate abundance cytokeratin (CK) 7 expression staining pattern in LCNEC. Overall, pulmonary urinary exhibited several CK7 patterns, including negative (n=28), dot-like (n=73),...
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (PD12)1 May 2024PD12-06 THE IMPACT OF URINARY MICROBIOTA COMPOSITION ON IMMUNE AND INFLAMMATORY RESPONSES IN A HEALTHY MOUSE MODEL Dalia Othman, Igor Moskalev, Ana Luque-Badillo, Cesar Monjaras-Avila, Sarah Hanstock, Felipe Eltit, Sheryl Munshan, Breanna Nelson, Alberto Contreras-Sanz, Peter Black, and Dirk Lange OthmanDalia Othman , MoskalevIgor Moskalev Luque-BadilloAna Luque-Badillo Monjaras-AvilaCesar...