A5016748099- Vestibular and auditory disorders
- Acute Ischemic Stroke Management
- Ophthalmology and Eye Disorders
- Cerebrovascular and Carotid Artery Diseases
- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal Development and Disorders
- Stroke Rehabilitation and Recovery
- Genetic Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Venous Thromboembolism Diagnosis and Management
- Multiple Sclerosis Research Studies
- Intracranial Aneurysms: Treatment and Complications
Case Western Reserve University
2011-2025
Johns Hopkins University
2015-2025
National Institute of Neurological Disorders and Stroke
2002-2024
National Institutes of Health
2007-2024
Johns Hopkins Medicine
2013-2024
Johns Hopkins Hospital
1982-2024
Massachusetts General Hospital
2011-2024
Rhode Island Hospital
2024
Cooper Medical School of Rowan University
2024
Dow University of Health Sciences
2024
REVIEWER'S ADDRESS: Kenneth J. Ciuffreda State University of New York College Optometry 100 East 24th Street York, 10010
To characterize intracranial plaque inflammation in vivo by using three-dimensional (3D) high-spatial-resolution contrast material-enhanced black-blood (BB) magnetic resonance (MR) imaging and to investigate the relationship between cerebrovascular ischemic events.The study was approved institutional review board HIPAA compliant. Twenty-seven patients (19 men; mean age, 56.8 years ± 12.4 [standard deviation]) with events (acute stroke, n = 20; subacute 2; chronic 3; transient attack, 2)...
Background and Purpose— Preliminary studies suggest that intracranial arteries are capable of accommodating plaque formation by remodeling. We sought to study the ability extent remodel using 3-dimensional high-resolution black blood magnetic resonance imaging investigate its relation ischemic events. Methods— Forty-two patients with cerebrovascular events underwent time-of-flight angiography contrast-enhanced examinations at 3 T for atherosclerotic disease. Each was classified location (eg,...
Abstract We measured the stability of gaze in horizontal and vertical planes, 2 patients with bilaterally deficient vestibular function while they sat, stood still, walked place, made active head rotations. During sitting standing, was equally as stable that normal subjects. walking however, velocity double Thus, our patients' complaints impaired vision oscillopsia during could be ascribed to excessive motion images on their retinas. Eye movements compensated for rotations more effectively...
We studied eye movements in 50 patients with Huntington9s disease. Fixation was impaired 73% of patients; such individuals had difficulty suppressing saccades toward novel visual stimuli. Impaired initiation manifest by increased reaction time (89%) and inability to make a saccade without head movement or blink (35%). Saccades quick phases nystagmus were slowed 62%. Smooth pursuit abnormal 60%, vergence 33%. The vestibulo-ocular reflex the ability hold eccentric gaze preserved even late
Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the lay public has led to its frequent consideration in differential diagnosis patients with rapidly progressive dementia (RPD). Our goal was determine which treatable disorders are most commonly mistaken for CJD.We performed a retrospective clinical neuropathological review prion-negative brain autopsy cases referred US National Prion Disease Pathology Surveillance Center at Case Western Reserve University from...
Abstract We conducted a double‐blind crossover trial comparing gabapentin (up to 900 mg/day) baclofen 30 as therapy for acquired nystagmus in 21 patients. measured visual acuity and the before, at end of, 2 weeks on each medication. For group of 15 patients with pendular (APN), improved significantly gabapentin, but not baclofen. Gabapentin reduced APN median eye speed all three planes, did so only vertical plane. In 10 APN, reduction was substantial 8 these elected continue taking drug. 6...
We investigated all patients in Maryland reported to have Huntington9s disease (HD), and found considerable diagnostic inaccuracy. Fifteen percent of cases as HD actually had some other diagnosable condition; 11% that met criteria for been given diagnosis. Diagnostic errors could be reduced by documentation the family history systematic interviewing relatives demonstration characteristic disorder voluntary movement addition chorea.
The inferior olivary nuclei clearly play a role in creating oculopalatal tremor, but the exact mechanism is unknown. Oculopalatal tremor develops some time after lesion brain that interrupts inhibition of olive by deep cerebellar nuclei. Over gradually becomes hypertrophic and its neurons enlarge developing abnormal soma-somatic gap junctions. However, results from several experimental studies have confounded issue because they seem inconsistent with for or ascribe to other areas. Here we...
Functional imaging studies of healthy participants and previous lesion have provided evidence that empathy involves dissociable cognitive functions rely on at least partially distinct neural networks can be individually impaired by brain damage. These converge in support the proposal affective empathy—making inferences about how another person feels—engages following areas: prefrontal cortex, orbitofrontal gyrus, anterior insula, cingulate temporal pole, amygdala temporoparietal junction. We...
Progressive supranuclear palsy (PSP) is a disease of later life that currently regarded as form neurodegenerative tauopathy. Disturbance gaze cardinal clinical feature PSP often helps clinicians to establish the diagnosis. Since neurobiology control now well understood, it possible use eye movements investigational tools understand aspects pathogenesis PSP. In this review, we summarize each disorder occurs in PSP, drawing on our studies fifty patients, and reports from other laboratories...
The eyes do not stay perfectly still during attempted fixation; fixational eye movements and saccadic intrusions (SIs) continuously change the position of gaze. most common type SI, square-wave jerks (SWJs), consists saccade pairs that appear purely horizontal on clinical inspection: first moves away from fixation target, after a short interval, second brings it back toward target. SWJs are prevalent in certain neurological disorders, including progressive supranuclear palsy (PSP). Here, we...
The Stroke Imaging Research (STIR) group, the Working Group of StrokeNet, American Society Neuroradiology, and Foundation Neuroradiology sponsored an imaging session workshop during Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. purpose this roadmap was focus role future research clinical trials.This forum brought together stroke neurologists, neuroradiologists, neuroimaging scientists, members National Institute Neurological Disorders (NINDS),...
Factors contributing to cerebral edema in the post-hyperacute period of ischemic stroke (first 24-72 hours) are poorly understood. Blood-brain barrier (BBB) disruption and postischemic hyperperfusion reflect microvascular dysfunction associated with hemorrhagic transformation. We investigated relationships between BBB integrity, blood flow, space-occupying patients who received acute reperfusion therapy.
Background Poor venous outflow (VO) profiles are associated with unfavorable outcomes in patients acute ischemic stroke caused by large vessel occlusion (AIS-LVO), despite achieving successful reperfusion. The objective of this study is to assess the association between mortality and prolonged transit (PVT), a novel visual qualitative VO marker on CT perfusion (CTP) time maximum (Tmax) maps. Methods We performed retrospective analysis prospectively collected data from consecutive adult...
Abstract We studied dynamic properties of horizontal, vertical, and oblique eye movements in 23 patients with the following parkinsonian syndromes: idiopathie parkinsonism (PD), multiple system atrophy (MSA), pure akinesia (PA), progressive supranuclear palsy (PSP), cortical‐basal ganglionic degeneration (CBGD). Compared age‐matched controls, only PSP showed slowing saccades. Patients all groups saccadic hypometria that was most marked vertically. The trajectories saccades made to diagonal...