Patricia Desmond
A5038211666- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Cardiac Imaging and Diagnostics
- Brain Tumor Detection and Classification
- Schizophrenia research and treatment
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Lysosomal Storage Disorders Research
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Neurosurgical Procedures and Complications
- Fetal and Pediatric Neurological Disorders
- Neurological and metabolic disorders
- Medical Imaging and Analysis
The University of Melbourne
2016-2025
The Royal Melbourne Hospital
2016-2025
Christchurch Hospital
2021-2024
Royal Adelaide Hospital
2021-2024
Florey Institute of Neuroscience and Mental Health
2006-2023
The Alfred Hospital
2023
Gold Coast Hospital
2023
Royal North Shore Hospital
2023
Monash University
2009-2023
Monash Health
2023
Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes.We randomly assigned patients with who were receiving 0.9 mg alteplase per kilogram body weight less than 4.5 hours after the onset either undergo thrombectomy Solitaire FR (Flow Restoration) stent retriever or continue alone. All had occlusion internal carotid middle...
The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited within 4.5 hours after the onset of symptoms. Some trials have suggested that treatment window may be extended in patients who are shown but not yet infarcted brain tissue on imaging.
Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy ischemic stroke. Tenecteplase, which more fibrin-specific and has longer activity than alteplase, given as a bolus may increase the incidence vascular reperfusion.
Hyperglycemia at the time of ischemic stroke is associated with increased mortality and morbidity. Animal studies suggest that infarct expansion may be responsible. The influence persisting hyperglycemia after has not previously been examined. We measured blood glucose profile acute correlated it volume changes using T2- diffusion-weighted MRI.We recruited 25 subjects within 24 hours symptoms. Continuous monitoring was performed a device (CGMS), 4-hour capillary levels (BGL) were for 72...
Context: Magnetic resonance imaging studies have identified hippocampal volume reductions in schizophrenia and amygdala enlargements bipolar disorder, suggesting different medial temporal lobe abnormalities these conditions.These been limited by small samples the absence of patients early course illness.Objective: To investigate volumes a large sample with chronic schizophrenia, first-episode psychosis, at ultra-high risk for psychosis compared control subjects.Design: Cross-sectional...
Abstract Controversy exists whether acute hyperglycemia is causally associated with worse stroke outcome or simply reflects a more severe stroke. In reversible ischemia models, lactic acidosis and conversion of penumbral tissue to infarction. However, the relationship between hyperglycemia, acidosis, has not been explored in humans. Sixty‐three patients were prospectively evaluated serial diffusion‐weighted perfusion‐weighted magnetic resonance imaging blood glucose measurements. Patients...
<b>Objectives: </b> We examined the utility of echoplanar magnetic resonance perfusion imaging and diffusion-weighted (DWI) in predicting stroke evolution outcome 18 patients with acute hemispheric infarction. <b>Methods: Patients were studied within 24 hours (mean, 12.2 hours), subacutely(mean, 4.7 days), at 84 days). Comparisons made between infarction volumes as measured on (PI) isotropic DWI maps, clinical assessment scales (Canadian Neurological Scale, Barthel Index, Rankin Scale),...
PURPOSE: To determine the histopathologic findings of patellar tendinosis ("jumper's knee") demonstrated with ultrasonography (US) and magnetic resonance (MR) imaging. MATERIALS AND METHODS: Twenty-four athletes (28 knees) jumper's knee (23 men, one women; mean age, 30.9 years) scheduled to undergo open tenotomy underwent US tendon examination. Seventeen patients (19 also MR Tissue was obtained for examination in all 28 cases. Eleven age-, height-, weight-matched (22 without previous...
CT perfusion (CTP) is widely and rapidly accessible for imaging acute ischemic stroke but has limited validation. Cerebral blood volume (CBV) been proposed as the best predictor of infarct core. We tested CBV against other common CTP parameters using contemporaneous diffusion MRI.Patients with stroke<6 hours after onset had MRI<1 hour apart, before any reperfusion therapies. maps time to peak (TTP), absolute relative CBV, cerebral flow (CBF), mean transit (MTT), deconvolved tissue residue...
Background and Purpose— Intracerebral hemorrhage (ICH) growth predicts mortality functional outcome. We hypothesized that irregular hematoma shape density heterogeneity, reflecting active, multifocal bleeding or a variable time course, would predict ICH growth. Methods— Three raters examined baseline sub-3-hour CT brain scans of 90 patients in the placebo arm Phase IIb trial recombinant activated Factor VII ICH. Each rater, blinded to data, independently applied novel 5-point categorical...
Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but have not previously been demonstrated humans. We correlated leptomeningeal assessed using novel perfusion magnetic resonance imaging (MRI) processing at baseline and 3 5 days, with simultaneous assessment of parameters. Perfusion raw data were averaged across three consecutive slices increase vessel continuity after subtraction signal analogous digital angiography....
Background and Purpose— The aim of this study was to determine if automated MRI analysis software (RAPID) can be used identify patients with stroke in whom reperfusion is associated an increased chance good outcome. Methods— Baseline diffusion- perfusion-weighted scans from the Diffusion Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE; n=74) Echoplanar Thrombolytic Trial (EPITHET; n=100) were reprocessed RAPID. Based on RAPID-generated diffusion-weighted imaging...
See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration subjects who test positive amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with to accelerate Alzheimer's disease progression. Here, we applied quantitative susceptibility mapping, relatively new magnetic resonance imaging method sensitive tissue iron, assess the relationship between load,...
<h3>Importance</h3> Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared alteplase. <h3>Objective</h3> To determine whether 0.40 mg/kg of safely before vs 0.25 in patients large vessel occlusion stroke. <h3>Design, Setting, and Participants</h3> Randomized clinical trial at 27 hospitals Australia 1 New Zealand using open-label treatment blinded assessment radiological outcomes. Patients were enrolled from December...
Background and Purpose— Perfusion imaging has the potential to select patients most likely respond thrombolysis. We tested correspondence of computed tomography perfusion (CTP)-derived mismatch with contemporaneous perfusion-diffusion magnetic resonance (MRI). Methods— Acute ischemic stroke 3 6 hours after onset had CTP MRI within 1 hour, before Relative cerebral blood flow (relCBF) time peak deconvolved tissue residue function (Tmax) were calculated. The diffusion lesion (diffusion-weighted...
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging common epilepsy syndromes, including temporal lobe epilepsy, extratemporal and genetic generalized epilepsy. Our goal was rank the most robust matter microstructural differences across within syndromes multicentre sample adult patients. Diffusion-weighted MRI were analysed from...
Background Implantable brain–computer interfaces (BCIs), functioning as motor neuroprostheses, have the potential to restore voluntary impulses control digital devices and improve functional independence in patients with severe paralysis due brain, spinal cord, peripheral nerve or muscle dysfunction. However, reports date had limited clinical translation. Methods Two participants amyotrophic lateral sclerosis (ALS) underwent implant a single-arm, open-label, prospective, early feasibility...
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In past decade, development new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), enabled for more comprehensive investigation iron distribution brain. The aim this systematic review was to provide a synthesis findings from existing QSM studies We identified 80 records by searching MEDLINE, Embase, Scopus, and PsycInfo databases. disorders investigated these included...
Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify associations with atrophy patterns in 1021 adults epilepsy compared 1564 healthy controls from 19 international sites. temporal lobe epilepsy, areas of colocalized highly interconnected cortical hub regions, whereas idiopathic generalized showed preferential subcortical involvement. These morphological abnormalities were anchored...