A5048042745- Animal Virus Infections Studies
- Acute Ischemic Stroke Management
- Viral gastroenteritis research and epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Plant Virus Research Studies
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Animal Disease Management and Epidemiology
- Viral-associated cancers and disorders
- Insect and Pesticide Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Vascular Malformations Diagnosis and Treatment
- Vector-Borne Animal Diseases
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Moyamoya disease diagnosis and treatment
- Aortic Disease and Treatment Approaches
- Bacteriophages and microbial interactions
- Parvovirus B19 Infection Studies
Liverpool Hospital
2016-2025
Prince of Wales Hospital
2016-2025
Sydney Children's Hospital
2024
Ingham Institute
2017-2023
UNSW Sydney
2021-2023
Rockefeller University
2023
Florey Institute of Neuroscience and Mental Health
2023
McMaster University
2023
South Western Sydney Local Health District
2021
North Shore Hospital
2020
A clone of human cells (Detroit 6) latently infected by adeno-associated virus (AAV) has been characterized with regard to the status viral DNA. In both early (9 10) and late (118) passages clone, AAV-DNA was recombined host DNA, at least in some cases as a head-to-tail tandem repeat, via terminal sequences genome. However, it not possible distinguish between integration into chromosomal DNA very large plasmids (< 20 x 10(6) molecular weight) which contain cellular sequences. Although...
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn IFN-α/β-dependent intrinsic viral diseases. Both types IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria related intramacrophagic pathogens. These have no history severe disease, despite exposure to many viruses, including...
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of injury is uncertain. Objective To describe relationship between imaging estimates irreversibly injured brain (core) at-risk regions (mismatch) clinical outcomes EVT treatment effect. Design, Setting, Participants An exploratory analysis SELECT2 trial, which randomized 352 adults (18-85 years) due to occlusion internal carotid or middle cerebral...
Although previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We aimed to compare outcomes e-ICA occlusion infarcts treated EVT vs medical management (MM). This was a secondary analysis SELECT2 trial, randomized controlled trial conducted at 31 international sites. Adult proximal intracranial anterior circulation defined as Alberta...
Two of the Sal I fragments and all internal BamHI (with exception c, a 0.6 x 10(6) dalton fragment) Epstein-Barr virus (EBV) DNA have been cloned in pBR322. The termini other parts (including EcoRI fragment which contains c) as bacteriophage Charon 4A. DNAs used to derive complete map EBV align BamHI, EcoRI, HindIII, SalI cleavage sites DNA.
Background The Pipeline Embolisation Device with Shield technology (PED-Shield) is suggested to have reduced thrombogenicity. This thrombogenicity may make it possible use safely in the acute treatment of aneurysmal subarachnoid haemorrhage (aSAH) on single antiplatelet therapy (SAPT). Objective To evaluate safety and efficacy off-label PED-Shield SAPT for aSAH. Methods Patients who underwent ruptured intracranial aneurysms were retrospectively identified from prospectively maintained...
<h3>BACKGROUND AND PURPOSE:</h3> Numerous reports of treatment wide-neck aneurysms by flow diverters have been published; however, long-term outcomes remain uncertain. This article the imaging results unruptured treated electively with Pipeline Embolization Device for up to 56 months and clinical 61 months. <h3>MATERIALS METHODS:</h3> One hundred nineteen in 98 patients from 3 centers admitted between August 2009 June 2011 were followed at 6-month, 1-year, 2+-year postprocedural timeframes....
Background: There is limited data on ultra-early hematoma growth dynamics and its clinical relevance in primary intracerebral hemorrhage (ICH). We aimed to estimate the incidence of expansion (HE) within hyperacute period ICH, describe over time, investigate associations between HE outcomes after assess effect tranexamic acid HE. Methods: performed a planned secondary analysis STOP-MSU international multicenter randomized controlled trial. Repeat CT imaging ~1 hour treatment commencement was...
At least three separate regions of the Epstein-Barr virus (EBV) genome encode RNA in a cell line that is growth transformed and nonpermissively infected with EBV. Six polyadenylylated cytoplasmic RNAs have been identified from these regions. An abundant 3.0-3.1 kilobases (kb) long encoded by DNA internal reiteration, IR, maps at 25.7-30 megadaltons. A second, abundant, 2.9-kb primarily 110-03 megadaltons but probably has 3' end to left 110 third, 3.7-kb largely 63-66 5' 63 less-abundant...
A collection of overlapping cDNA clones encoding the latency transcript pseudorabies virus and DNA nucleotide sequence gene has been obtained. The is spliced with 4.6 kb intervening sequences. This mRNA, designated large transcript, 8.5 kb. It polyadenylated contains a open reading frame capable coding for 200-kDa polypeptide. direction transcription antiparallel to that immediate-early IE180 newly identified early gene, EP0. overlaps entire most EP0 gene. mRNA 1.75 polyadenylated. deduced...
Journal Article DNA nucleotide sequence analysis of the immediate-early gene pseudorabies virus Get access Andrew K. Cheung USDA, Agricultural Research Service. National Animal Disease CenterAmes, IA 50010, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 12, 26 June 1989, Pages 4637–4646, https://doi.org/10.1093/nar/17.12.4637 Published: 1989 history Received: 24 February Revision received: 11 May Accepted:
The nucleotide sequence of the long internal reiteration. IR1, Epstein-Barr Virus DNA has been determined. repeat unit is 3,071 base pairs which are 66.8% guanine plus cytosine. There a CCAAT 39 nucleotides 5' to TATAA, could indicate promotor for transcription. longest open reading frame 1,124 pairs. Also within IR1 homologous papovavirus origin replication. ori-like palindromic region 500 overall. palidromic shares common features with Alu family members and eucaryotic transposable...
The genome and transcriptional pattern of a newly identified respiratory variant transmissible gastroenteritis virus were analyzed compared with those classical enterotropic virus. patterns the two viruses indicated that differences occurred in RNAs 1 2(S) RNA 3 was absent porcine coronavirus (PRCV) variant. smaller PRCV due to 681-nucleotide (nt) deletion after base 62 peplomer or spike (S) gene. S gene still retained information for 16-amino-acid signal peptide first 6 amino acid residues...
Polypeptides expressed on the surface of merozoites, invasive stage asexual blood cycle, are good candidates for development malaria vaccines. Five synthetic peptides with predetermined specificity deduced from a genomic DNA clone coding NH2-terminal portion main merozoite polypeptide Plasmodium falciparum were evaluated their capability to raise antibodies that react P. merozoites. Antibodies induced by two (3 and 5) reacted membrane surfaces seven isolates different geographic areas....
Two pseudorabies virus (PRV) poly(A)+ RNAs, 2.0 and 0.95 kilobases, were detected in the trigeminal ganglia of latently infected pigs. These RNAs partially colinear at 3' end. They located BamHI J fragment (0.706 to 0.737 map units), PRV immediate-early gene. A potential polyadenylation signal was also identified BamHI-J. The direction transcription latency-associated antiparallel (i.e., opposite polarity) that mRNA.
Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials endovascular thrombectomy (EVT). Meta-analysis "real world" studies evaluating 90-day outcomes elderly ≥80 years have been limited to small numbers undergoing EVT with older generation devices. Methods: A retrospective analysis 181 prospectively collected who received anterior circulation AIS at an Australian center over 2.5-years. The study aims determine (i)...