Nabeel Herial
A5064393538- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Migraine and Headache Studies
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Long-Term Effects of COVID-19
- Central Venous Catheters and Hemodialysis
- Aortic aneurysm repair treatments
- Cerebrospinal fluid and hydrocephalus
- Neurological Complications and Syndromes
- Atrial Fibrillation Management and Outcomes
- Healthcare Systems and Practices
- COVID-19 and healthcare impacts
- Aortic Disease and Treatment Approaches
- Retinal and Optic Conditions
- COVID-19 Clinical Research Studies
Thomas Jefferson University Hospital
2018-2025
Neurological Surgery
2018-2025
Thomas Jefferson University
2017-2025
Jefferson Hospital
2024
Jefferson University Hospitals
2018-2024
Jefferson Hospital for Neuroscience
2018-2021
Oxford University Press (United Kingdom)
2020
CHI St. Vincent
2019
Good Samaritan Hospital Medical Center
2019
Institute for Health Metrics and Evaluation
2019
Stroke is a leading cause of mortality and disability worldwide the economic costs treatment post-stroke care are substantial. The Global Burden Diseases, Injuries, Risk Factors Study (GBD) provides systematic, comparable method quantifying health loss by disease, age, sex, year, location to provide information systems policy makers on more than 300 causes disease injury, including stroke. results presented here estimates burden due overall stroke ischaemic haemorrhagic from GBD 2016.
Trials of the efficacy and safety endovascular thrombectomy in patients with large ischemic strokes have been carried out limited populations. Download a PDF Research Summary. We performed prospective, randomized, open-label, adaptive, international trial involving stroke due to occlusion internal carotid artery or first segment middle cerebral assess within 24 hours after onset. Patients had ischemic-core volume, defined as an Alberta Stroke Program Early Computed Tomography Score 3 5...
Despite the well-established potent benefit of mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke, access to MT has not been studied globally. We conducted a worldwide survey countries on 6 continents define (MTA), disparities in MTA, and its determinants global scale.Our was 75 through Mission Thrombectomy 2020+ network between November 22, 2020, February 28, 2021. The primary end points were current annual operator availability, center availability. MTA defined as...
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of injury is uncertain. Objective To describe relationship between imaging estimates irreversibly injured brain (core) at-risk regions (mismatch) clinical outcomes EVT treatment effect. Design, Setting, Participants An exploratory analysis SELECT2 trial, which randomized 352 adults (18-85 years) due to occlusion internal carotid or middle cerebral...
Although previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We aimed to compare outcomes e-ICA occlusion infarcts treated EVT vs medical management (MM). This was a secondary analysis SELECT2 trial, randomized controlled trial conducted at 31 international sites. Adult proximal intracranial anterior circulation defined as Alberta...
To examine the prevalence of childhood maltreatment and adult revictimization in migraineurs association with sociodemographic factors, depression anxiety.Population practice-based studies have demonstrated an abuse headache adults, although further details on diagnoses, characteristics, comorbid conditions are lacking. There mounting data suggesting substantial impact early physical mental health.Electronic surveys were completed by patients seeking treatment 11 centers across United States...
Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. acute ischemic stroke safe feasible in pilot trials. We designed study protocol to provide safer, faster therapeutic patients.Safety procedures 4°C saline infusions cooling were added the ICTuS trial (Intravascular Cooling Treatment of Stroke) protocol. A femoral venous intravascular catheter intravenous recombinant tissue-type plasminogen activator...
There is mounting evidence of endothelial activation and dysfunction in migraine. Our objectives were to determine a population premenopausal women whether markers are associated with migraine.Women (18 50 years) without migraine free from cardiovascular disease evaluated tests coagulation (von Willebrand factor activity, prothrombin fragment), fibrinolysis (tissue-type plasminogen activator antigen), inflammation (high-sensitivity C-reactive protein), oxidative stress (homocysteine, total...
Background.— Cutaneous allodynia (CA) in migraine is a clinical manifestation of central nervous system sensitization. Several chronic pain syndromes and mood disorders are comorbid with migraine. In this study we examine the relationship migraine‐associated CA these conditions. We also evaluate association factors such as demographic profiles, characteristics, smoking status that may have an influence on relationships to mood. Methods.— Data from cross‐sectional multicenter conditions...
( Headache 2010;50:32‐41) Objectives.— To assess in a headache clinic population the relationship of childhood abuse and neglect with migraine characteristics, including type, frequency, disability, allodynia, age onset. Background.— Childhood maltreatment is highly prevalent has been associated recurrent headache. Maltreatment many same risk factors for chronification, depression anxiety, female sex, substance abuse, obesity. Methods.— Electronic surveys were completed by patients seeking...
Robots in surgery aid performing delicate, precise maneuvers that humans, with inherent physical abilities, may be limited to perform. The CorPath 200 system is FDA approved and being implemented the US for interventional cardiology procedures. GRX robotic-assisted platform next-generation successor of 200.To discuss feasibility early experience use neuroendovascular procedures, including transradial diagnostic cerebral angiograms carotid artery stenting.The cases 10 consecutive patients who...
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).
To evaluate in a headache clinic population the relationship of childhood maltreatment on prevalence pain conditions comorbid with migraine.Childhood is highly prevalent and has been frequently associated recurrent headache. The has, however, subject some debate.Cross-sectional data self-reported physician-diagnosed were electronically collected from persons migraine (diagnosed according to International Classification Headache Disorders-2), seeking treatment clinics at 11 centers across US...
To identify distinct constellations of comorbid disorders occurring in migraineurs, and to examine differences demographics, headache profiles, psychosocial features between the comorbidity constellations.This is a retrospective electronic chart review consecutive new female outpatients diagnosed with migraine (n = 223) using International Classification Headache Disorders (ICHD)-II criteria. Questionnaire collected information on diagnoses, current depression, somatic symptoms, stressors,...
Objective.—To examine the headache characteristics of women with migraine and endometriosis (EM), differences in prevalence comorbid conditions between female migraineurs EM, without EM nonheadache controls. Background.—Migraine are common reproductive age, both influenced by ovarian hormones. The comorbidity is newly recognized, but reasons for association uncertain. Methods.—This a cross‐sectional study outpatients healthy controls conducted at University Toledo Duke 2005 2006. After...
Objectives.— Migraine is a risk factor for stroke in young women. Biomarker studies implicate endothelial activation as possible mechanism. Emerging relationships of childhood adversity with migraine, and inflammation, component activation, suggest that it may play role the migraine–stroke association. Our objective to evaluate relationship between adverse experiences (ACEs), vascular biomarker levels premenopausal Methods.— Vascular metabolic biomarkers from women 18‐50 years, including 125...
Limited data are available about the outcomes of mechanical thrombectomy (MT) for real-world patients with stroke presenting a large core infarct.To investigate safety and effectiveness MT vessel occlusion an Alberta Stroke Program Early Computed Tomography Score (ASPECTS) 2 to 5.This retrospective cohort study used from Thrombectomy Aneurysm Registry (STAR), which combines prospectively maintained databases 28 thrombectomy-capable centers in US, Europe, Asia. The included 2345 internal...
During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations ruptured aneurysm coiling interventions demonstrated similar declines.We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries 140 comprehensive centres. Patients with diagnosis SAH, aneurysmal identified by prospective databases or International...
The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.To describe the efficacy acute revascularization large vessel occlusion (LVO) setting COVID-19 an international cohort.We conducted multicenter retrospective study consecutively admitted patients with concomitant LVO across 50 comprehensive centers. Our control group constituted historical controls presenting receiving a mechanical thrombectomy between January 2018...
BACKGROUND: Symptomatic intracranial atherosclerotic disease (sICAD) is estimated to cause 10% of strokes annually in the United States. However, treatment remains a challenge with several different stenting options studied past unfavorable results. OBJECTIVE: To report 30-day stroke and/or death rate associated stent placement for sICAD using Resolute Onyx Zotarolimus-Eluting Stent (RO-ZES) and provide comparison results Stenting Versus Aggressive Medical Management Preventing Recurrent...
Objective.—To discern the effects of depression and anxiety on migraine–obesity relationship. Background.—Migraine obesity are highly prevalent conditions both independently linked to psychiatric conditions, mainly anxiety. Methods.—Data from an ongoing cross‐sectional multicenter study comorbid in clinic patients seeking treatment for headache. The diagnosis migraine was determined by examining physician based International Classification Headache Disorders (ICHD)‐II criteria. Participants...