Mauricio Concha
A5053120888- HIV Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- HIV-related health complications and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Neurosurgical Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Cerebral Palsy and Movement Disorders
- HIV/AIDS Research and Interventions
- T-cell and Retrovirus Studies
- Cerebrovascular and Carotid Artery Diseases
- Animal Disease Management and Epidemiology
- Thermal Regulation in Medicine
- Intracranial Aneurysms: Treatment and Complications
- Foot and Ankle Surgery
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Vector-Borne Animal Diseases
- Botulinum Toxin and Related Neurological Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Infectious Encephalopathies and Encephalitis
- Stroke Rehabilitation and Recovery
- Lower Extremity Biomechanics and Pathologies
Sarasota Memorial Hospital
2005-2024
University of Cincinnati Medical Center
2024
University of Virginia
2024
Arcadia
2024
Centre Hospitalier Universitaire de Clermont-Ferrand
2023
Stanford University
2020
University of Cincinnati
2020
Phoenix Children's Hospital
2020
Massachusetts General Hospital
2020
Mayo Clinic in Florida
2020
Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, Participants Multicenter (277 medical research centers/hospitals in 8 countries), randomized, double-blind, placebo-controlled, 18-month phase 3 trial that enrolled 1736 participants with early symptomatic disease (mild cognitive impairment/mild dementia) low/medium or high tau pathology...
Andexanet alfa is a modified recombinant inactive form of human factor Xa developed for reversal inhibitors.We evaluated 352 patients who had acute major bleeding within 18 hours after administration inhibitor. The received bolus andexanet, followed by 2-hour infusion. coprimary outcomes were the percent change in anti-factor activity andexanet treatment and percentage with excellent or good hemostatic efficacy at 12 end infusion, adjudicated on basis prespecified criteria. Efficacy was...
We determined incidence and future projections of dementia after AIDS onset in 492 homosexual men with the Baltimore/Los Angeles sites Multicenter Cohort Study, 64 whom developed dementia. studied various risk factors for dementia, including demographic clinical features, medical history, markers immune status before AIDS, zidovudine use. During first 2 years HIV at an annual rate 7%. Overall, 15% cohort followed through death The median survival was 6.0 months. Using a proportional hazards...
Background: Andexanet alfa is a modified recombinant inactive factor Xa (FXa) designed to reverse FXa inhibitors. ANNEXA-4 (Andexanet Alfa, Novel Antidote the Anticoagulation Effects of Factor Inhibitors) was multicenter, prospective, phase-3b/4, single-group cohort study that evaluated andexanet in patients with acute major bleeding. The results final analyses are presented. Methods: Patients bleeding within 18 hours inhibitor administration were enrolled. Co-primary end points anti-FXa...
Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. acute ischemic stroke safe feasible in pilot trials. We designed study protocol to provide safer, faster therapeutic patients.Safety procedures 4°C saline infusions cooling were added the ICTuS trial (Intravascular Cooling Treatment of Stroke) protocol. A femoral venous intravascular catheter intravenous recombinant tissue-type plasminogen activator...
<i>Background and Relevance:</i> Atherosclerotic stenosis of the major intracranial arteries is an important cause transient ischemic attack (TIA) or stroke. Of 900,000 patients who suffer a TIA stroke each year in USA, responsible for approximately 10%, i.e. 90,000 patients. There have been no prospective trials evaluating antithrombotic therapies preventing recurrent vascular events these The main objective this trial to compare warfarin [International Normalized Ratio (INR)...
<h3>Objective:</h3> To investigate the temporal pattern and relevant associations of CSF inflammatory measures after intraventricular hemorrhage (IVH). <h3>Methods:</h3> We analyzed prospectively collected cell counts protein glucose levels from participants in Clot Lysis Evaluation Accelerated Resolution IVH phase III (CLEAR III) trial. Corrected leukocyte count index were calculated to adjust for leukocytes attributable circulating blood. Data chronologically plotted. (daily, mean, median,...
Twenty-three children who had unilateral surgery for idiopathic clubfeet underwent gait analysis and isokinetic muscle-strength testing at an average of 10 years after surgical release. Ankle sagittal-plane kinematics were disturbed in 20 clubfeet. Fifteen internal foot-progression angle. Genu valgum knee hyperextension common. Plantarflexion power was decreased by 23% on the side (p = 0.00005). Quadriceps weakness (defined as a decrease strength >10% nonoperated-on limb's strength) seen...
A definitive relation between HIV-1 load and the clinical diagnosis of HIV-1-associated dementia (HAD) has not yet been established. Knowledge neuroanatomic distribution in brain individuals with HAD encephalitis may facilitate elucidation this relation. Nine AIDS were analyzed postmortem by three independent methods each assessment performed blinded to others: 1) a neuropsychiatric review records for evidence possible HAD, 2) DNA determination quantitative polymerase chain reaction (PCR)...
To determine the frequency and characteristics of microembolic signals (MES) in subarachnoid hemorrhage (SAH).Twenty-three patients with aneurysmal SAH were monitored transcranial Doppler ultrasonography for presence MES vasospasm. Each middle cerebral artery was 30 minutes three times each week. Patients excluded if they had traumatic or cardiac arterial sources emboli. Monitoring initiated 6.3 days (1-16 d) after lasted 6.6 (1-13 d). Eleven individuals without other cerebrovascular...
A high-incidence focus of tropical spastic paraparesis (TSP) occurs on the South Pacific coast Colombia. Of 55 patients studied, 52 (94.5%) had IgG antibodies to human T-cell lymphotropic virus type I (HTLV-I) in serum and/or cerebrospinal fluid. Control groups did not show similar high positivity. Our results suggest that HTLV-I or other antigenically related retroviruses may be cause TSP Similar clinical, laboratory, and epidemiological findings have been reported widely remote...
Intravenous thrombolysis is a standard treatment of acute ischemic stroke. The efficacy and safety combining intravenous with argatroban (an anticoagulant agent) or eptifibatide antiplatelet are unclear.
Angular gyrus (Gerstmann) syndrome is classically described as finger agnosia, right-left disorientation, agraphia and acalculia in association to lesions the left angular gyrus. Aphasia not typically part of this syndrome. Here we report a 58 year old right-handed male, with an ischemic lesion gyrus, who developed sudden loss speech expression comprehension, slowly recovered over following few weeks. After several months he showed significant improvement on his language skills understanding...
Summary: In young adults, a major neurologic complication of HIV-1 infection is cognitive motor impairment. Epidemiologic findings suggest that increasing age significant risk factor for HIV-1-associated dementia as the AIDS-defining illness. Findings from few studies have directly measured cognition in younger and older HIV-1-infected however, been mixed, part, because small sample sizes other methodologic differences between studies. The authors present preliminary on functioning...
Background: The purpose of the study was to examine relationship between age and plasma viral load in HIV-1-infected individuals. Design: experimental method recruit older (> 50 years age) younger (18–39 measured using Roche Molecular Systems UltraSensitive HIV-1 Monitor test reflexively with standard Amplicor HIV quantify range 50–750 000 copies RNA/ml plasma. Subjects: A total 135 HIV-1-seropositive individuals (at Centers for Disease Control Prevention early symptomatic stage B or late...
The clinical syndrome earlier designated as paraparesia espástica del Pacífico is an isolated form of tropical spastic paraparesis (TSP) that was reported in 1981 the southern Pacific lowlands Colombia and near Tumaco. features are similar to those TSP Jamaica, Martinique, Seychelles, Ivory Coast Africa resemble also human T-lymphotropic virus type I (HTLV-I)-associated myelopathy described Japan. Since HTLV-I infection closely associated with TSP, we conducted a case-control study evaluate...
Twenty-three children who had unilateral surgery for idiopathic clubfeet underwent gait analysis and isokinetic muscle-strength testing at an average of 10 years after surgical release. Ankle sagittal-plane kinematics were disturbed in 20 clubfeet. Fifteen internal foot-progression angle. Genu valgum knee hyperextension common. Plantarflexion power was decreased by 23% on the side (p = 0.00005). Quadriceps weakness (defined as a decrease strength > 10% nonoperated-on limb's strength) seen...
Abstract Human immunodeficiency virus type 1 (HIV‐1) p24 antigen, a putative marker of load, was assayed in 79 blood and 83 cerebrospinal fluid (CSF) samples from 90 HIV‐1–seropositive individuals with or without demetia. Twenty‐eight subjects had no evidence neuropsychological impairment, 17 mild impairment objective dementia, 45 were demented. HIV‐1 antigen detected more frequently CSF demented (19/40) than normal (1/26) mildly impaired (1/17) 67% significant dementia (MSK stages 2–4)....
This study presents an analysis of the factors associated with HTLV-I seroprevalence in endemic area Tumaco, Colombia. During June to August 1988, 1,077 individuals were selected at random from a population 45,594. The overall prevalence rate antibodies was 2.8%. Among females significantly higher (p < 0.02) than among males. Rates increased substantially age. history use intravenous medications 0.001) those without such history. Logistic regression included age years, indicators for male...