Cynthia Adams
A5060157223- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes Management and Education
- Metabolism, Diabetes, and Cancer
- Health Policy Implementation Science
- Health and Wellbeing Research
- Legal Education and Practice Innovations
- Pancreatic function and diabetes
- Identity, Memory, and Therapy
- Aging and Gerontology Research
- Artificial Intelligence in Law
- Memory Processes and Influences
- Comparative and International Law Studies
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Conflict of Laws and Jurisdiction
- Pharmacology and Obesity Treatment
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Energy Efficiency and Management
- Aesthetic Perception and Analysis
- Educational Strategies and Epistemologies
- Galectins and Cancer Biology
- Antiplatelet Therapy and Cardiovascular Diseases
Milken Institute
2024
George Washington University
2024
University of Alabama at Birmingham
2024
Michigan Medicine
2024
Geriatric Research Education and Clinical Center
2024
University of Miami
2024
Cleveland Clinic
2024
University of Michigan–Ann Arbor
2023-2024
University of Puget Sound
2024
University of Washington
2024
Abstract Objective No drug is yet approved to treat the core symptoms of autism spectrum disorder ( ASD ). Low‐dose suramin was effective in maternal immune activation and Fragile X mouse models . The Suramin Autism Treatment‐1 SAT ‐1) trial a double‐blind, placebo‐controlled, translational pilot study examine safety activity low‐dose children with Methods Ten male subjects , ages 5–14 years, were matched by age, IQ severity into five pairs, then randomized receive single, intravenous...
OBJECTIVE To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity β-cell function. RESEARCH DESIGN AND METHODS In Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) cohort with type 2 diabetes (n = 4,801), HOMA2 was used estimate (HOMA2-%S) fasting function (HOMA2-%B) at baseline 1, 3, 5 years treatment. Oral glucose tolerance test...
We examined longitudinal associations between emotional distress (specifically, depressive symptoms and diabetes distress) medication adherence in Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE), a large randomized controlled trial comparing four glucose-lowering medications added to metformin adults with relatively recent-onset type 2 mellitus (T2DM).
Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in US. It not known whether glucose-lowering medications differentially affect function. Objective To evaluate outcomes Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness (GRADE) trial comparing 4 classes added to metformin for glycemic management individuals with T2D. Design, Setting, and Participants randomized clinical was conducted at 36 sites across included adults T2D less than 10 years, a...
OBJECTIVE We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative other treatments. RESEARCH DESIGN AND METHODS The Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE) of T2DM <10 years’ duration, HbA1c 6.8–8.5%, and taking monotherapy randomly assigned participants add glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist...
OBJECTIVE To describe the individual and joint associations of baseline factors with glycemia, also differential effectiveness medications added to metformin. RESEARCH DESIGN AND METHODS Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes diagnosed for <10 years, on metformin, HbA1c 6.8–8.5%; N = 5,047) were randomly assigned a basal insulin (glargine), sulfonylurea (glimepiride), glucagon-like peptide 1 agonist...
Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects glucose-lowering medications on cardiovascular outcomes individuals diabetes low risk are unclear. We investigated by treatment group participants randomly assigned to insulin glargine, glimepiride, liraglutide, or sitagliptin, added baseline metformin, GRADE (Glycemia Reduction Approaches Type Diabetes: A Comparative Effectiveness Study).
<i>Background and Relevance:</i> Atherosclerotic stenosis of the major intracranial arteries is an important cause transient ischemic attack (TIA) or stroke. Of 900,000 patients who suffer a TIA stroke each year in USA, responsible for approximately 10%, i.e. 90,000 patients. There have been no prospective trials evaluating antithrombotic therapies preventing recurrent vascular events these The main objective this trial to compare warfarin [International Normalized Ratio (INR)...
This study examined age differences in recall for the literal and interpretive meanings of narrative text. Following presentation one two stories rich both content, younger (mean = 19.2 years) older 72.2 adults were asked to retell interpret story. Response task order was counterbalanced across participants. When a story as close original possible, recalled more propositional content than did retell-first, although not interpret-first, condition. In addition, main ideas (gist) relative...
As the number of midlife women increases, there is an increased interest in women's experiences perimenopause. Because evidence linking estrogen with cholinergic and serotonergic activity brain central nervous system development dendritic arborization, mixed use incidence Alzheimer's disease, effects perimenopause on memory functioning are interest. The purpose these analyses, part Seattle Midlife Women's Health Study, was to describe changes perceived according their perimenopausal group,...
Journal Article Adult Age Group Differences in Story Recall Style Get access Cynthia Adams, Adams 1Center for Gerontology, University of Oregon Search other works by this author on: Oxford Academic PubMed Google Scholar Gisela Labouvie-Vief, Labouvie-Vief 2Department Psychology, Wayne State Cathy J. Hobart, Hobart Mary Dorosz Volume 45, Issue 1, January 1990, Pages P17–P27, https://doi.org/10.1093/geronj/45.1.P17 Published: 01 1990 history Received: 16 November 1987 Accepted: 27 March 1989
OBJECTIVE We report mortality outcomes in the Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE) among people with type 2 diabetes diagnosed within 10 years and no recent history of cardiovascular events or cancer. RESEARCH DESIGN AND METHODS Overall rates major causes death were assessed over an average 5 follow-up. Cause was adjudicated centrally by a committee masked to treatment assignment. examined baseline covariates 10-year Framingham Risk Score for...
OBJECTIVE To evaluate how model-based parameters of β-cell function change with glucose-lowering treatment and associate glycemic deterioration in adults type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In the Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE), derived from mathematical modeling oral glucose tolerance tests were assessed at baseline (N = 4,712) 1, 3, 5 years following randomization to insulin glargine, glimepiride, liraglutide, or...
The story-recall performance of older and younger women was examined within an oral story-retelling context with two listener conditions. Forty-eight (M age = 67.81 years; SD 2.62) 47 20.47 1.53) were asked to learn one stories the goal retell story from memory either experimenter or a young child. Did make difference in recall? Yes. Although age-group differences propositional recall favoring occurred when listener, there no child listener. In addition, listening, both tellers adapted their...
Qualitative differences in memory for text among 4 age groups (mean ages = 14.14, 17.55, 48.35, and 67.12 years) were examined this study. Participants produced written recall summary responses after presentation of a story an essay. The response protocols scored their reproductive, elaborative, metaphoric content. Age-group observed the quality responses. In general, adolescent reproductive based, whereas adult more reconstructive interpretive. especially apparent condition: adolescents...
OBJECTIVE GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin people with type 2 (T2DM). We report baseline characteristics and compare participants National Health Nutrition Examination Survey (NHANES) cohort. RESEARCH DESIGN AND METHODS Participants were age ≥30 years at the time of diagnosis, duration T2DM &lt;10 years,...
To assess women's beliefs about natural hormones, including what they believe the term "natural" means, and their risks, side effects, efficacy of hormone replacement compared to standard replacement.Eighty-two women completed a 20-item survey available at local compounding pharmacy. Respondents were white (100%), middle-aged (mean age, 47.22 years), college educated (95.1%); 32.9% perimenopausal, 50.0% postmenopausal; 58.5% currently using therapy and, those, 77.1% human bio-identical...
Islet autoimmunity may contribute to β-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. In this ancillary study the Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE), we investigated of cellular humoral islet patients with T2D duration 4.0 ± 3.0 years (HbA1c 7.5 0.5% on metformin alone). We measured T-cell autoreactivity against proteins, autoantibodies 65-kDa GAD antigen, IA-2, zinc...
OBJECTIVE To compare the effects of insulin sensitivity and β-cell function over time on HbA1c durability glycemic control in response to dual therapy. RESEARCH DESIGN AND METHODS GRADE participants were randomized glimepiride (n = 1,254), liraglutide 1,262), or sitagliptin 1,268) added baseline metformin followed for mean ± SD 5.0 1.3 years, with assessed quarterly oral glucose tolerance tests at baseline, 1, 3, 5 years. We related time-varying (HOMA 2 [HOMA2-%S]) early (0–30 min) total...
To evaluate whether baseline levels of depressive symptoms and diabetes-specific distress are associated with glycemic control in Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE), a large randomized controlled trial comparing the metabolic effects four common glucose-lowering medications when combined metformin individuals type 2 diabetes mellitus (T2DM).