A5051497639- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Adrenal Hormones and Disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Retinoids in leukemia and cellular processes
- Ion Transport and Channel Regulation
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- RNA and protein synthesis mechanisms
- Biochemical effects in animals
- Glycosylation and Glycoproteins Research
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Digestive system and related health
- Diet and metabolism studies
Indiana University Health
2012-2024
Indiana University – Purdue University Indianapolis
2010-2024
Group for the Analysis of Development
2023
Indiana University School of Medicine
2010-2023
IST Research
2010-2022
Prevent Blindness
2021
Research to Prevent Blindness
2021
Indianapolis Zoo
2018
University of Minnesota
2001-2016
Methodist Hospital
2011
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChanges in the hepatic levels of messenger ribonucleic acid for malic enzyme during induction by thyroid hormone or dietHoward C. Towle, Cary N. Mariash, and Jack H. OppenheimerCite this: Biochemistry 1980, 19, 3, 579–585Publication Date (Print):February 5, 1980Publication History Published online1 May 2002Published inissue 5 February 1980https://pubs.acs.org/doi/10.1021/bi00544a029https://doi.org/10.1021/bi00544a029research-articleACS...
We have investigated the relationship between administration of triiodothyronine (T3) and a high carbohydrate (CHO) fat-free diet in induction lipogenic enzymes two rat tissues, liver, fat. Male thyroidectomized rats were treated with graded daily doses T3 either supplemented CHO or left on regular diet. Enzymes studied included malic enzyme (ME), fatty acid synthetase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase. In all four showed synergistic response feeding. fat,...
OBJECTIVE To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity β-cell function. RESEARCH DESIGN AND METHODS In Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) cohort with type 2 diabetes (n = 4,801), HOMA2 was used estimate (HOMA2-%S) fasting function (HOMA2-%B) at baseline 1, 3, 5 years treatment. Oral glucose tolerance test...
We examined longitudinal associations between emotional distress (specifically, depressive symptoms and diabetes distress) medication adherence in Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE), a large randomized controlled trial comparing four glucose-lowering medications added to metformin adults with relatively recent-onset type 2 mellitus (T2DM).
We have compared the affinities for T3 and analog binding characteristics of in vitro translational products seven c-erbA cDNAs (chicken cerbA α human placental β rat β-1; α-1; α-2; testis kidney α-2). Four these α, β, β-1, α-1) bound with high affinity as previously described. When under identical conditions synthesis [125I]T3 binding, there was no significant difference between chicken c-erb Aα-1 but a more limited series β-1 4.6-fold higher than that α-1. In β-probes showed characteristic...
"Spot 14" is a nuclear protein that rapidly induced by thyroid hormone (T3) and dietary carbohydrate in liver. We used an antisense oligonucleotide to inhibit induction of spot 14 T3 glucose primary cultures rat hepatocytes test the hypothesis could function regulation lipid synthesis. Spot was undetectable maintained 5.5 mM without T3, within 4 h after addition 27.5 50 nM culture medium, reaching maximal level 24 h. Accumulation markedly inhibited transfected with oligonucleotide, but not...
We have compared the dose of levothyroxine (L-T4) required to suppress serum TSH given levels in two clinical groups: 1) 44 patients with thyroid cancer whose glands had been ablated by surgical thyroidectomy and 131I treatment, 2) 113 thyroidal failure due either spontaneous primary hypothyroidism (31 patients) or after treatment for Graves' hyperthyroidism (82 patients). The L-T4 needed attain euthyroid range (0.5-6.2 microU/mL) was significantly greater (P less than 0.01) (2.11...
We have measured the plasma protein binding of [125I]T4 and [125I]T3 in several groups patients using assays equilibrium dialysis by dextran-coated charcoal carriedout under conditions physiological pH. Subjects included 45 with nonthyroidalillnesses (NTI), 5 hyperthyroidism, hypothyroidism, 1 familial low T4-binding globulin (TBG), 11 healthy controls. Both test results wereexpressed as ratio nonprotein-bound to protein-bound hormone, which was normalizedto average obtained for control...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteractions of thyroid hormone, growth and high carbohydrate, fat-free diet in regulating several rat liver mRNA speciesChen Liaw, Steven Seelig, Cary N. Mariash, Jack H. Oppenheimer, Howard C. TowleCite this: Biochemistry 1983, 22, 1, 213–221Publication Date (Print):January 4, 1983Publication History Published online1 May 2002Published inissue 4 January...
Introduction/Purpose Relacorilant is a selective glucocorticoid receptor modulator (SGRM) with no progesterone activity. We evaluated the efficacy and safety of relacorilant in patients endogenous Cushing syndrome (CS). Materials Methods A single-arm, open-label, phase 2, dose-finding study 2 dose groups (NCT02804750, https://clinicaltrials.gov/ct2/show/NCT02804750 ) was conducted at 19 sites U.S. Europe. Low-dose (100-200 mg/d; n = 17) administered for 12 weeks or high-dose (250-400 18) 16...
OBJECTIVE We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative other treatments. RESEARCH DESIGN AND METHODS The Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE) of T2DM <10 years’ duration, HbA1c 6.8–8.5%, and taking monotherapy randomly assigned participants add glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist...
OBJECTIVE To describe the individual and joint associations of baseline factors with glycemia, also differential effectiveness medications added to metformin. RESEARCH DESIGN AND METHODS Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes diagnosed for <10 years, on metformin, HbA1c 6.8–8.5%; N = 5,047) were randomly assigned a basal insulin (glargine), sulfonylurea (glimepiride), glucagon-like peptide 1 agonist...
Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects glucose-lowering medications on cardiovascular outcomes individuals diabetes low risk are unclear. We investigated by treatment group participants randomly assigned to insulin glargine, glimepiride, liraglutide, or sitagliptin, added baseline metformin, GRADE (Glycemia Reduction Approaches Type Diabetes: A Comparative Effectiveness Study).
Thyroid hormone (TH) is necessary for normal axonal myelination. Myelin basic protein (MBP) a structural essential myelin function. In this study, we demonstrate that perinatal hypothyroidism regulates MBP mRNA levels via indirect mechanisms. We observed decreased accumulation in the hypothyroid rat brain at postnatal (PN) d 10 and 50. Acute TH replacement did not rescue PN5, 10, or intrahemispheric commissure development including anterior (AC) corpus callosum (CC). determined decreases AC...
Recent studies have shown that hepatic rnRNASl4 responds rapidly to thyroid hormone administration.Moreover, this mRNA is known increase in mass with the administration of a high carbohydrate fatfree diet.Therefore, it appears share many same properties lipogenic enzymes.Because enzymes display synergistic interaction between hormones and carbohydrates, we investigated kinetics response mRNAslr feeding, as well its triiodothyronine
We generated a Spot 14 null mouse to assess the role of in de novo lipid synthesis and report exhibits phenotype lactating mammary gland. pups nursed by dams gain significantly less weight than wild-type dams. In contrast, heterozygous show similar littermates. found triglyceride content milk is reduced. demonstrate this reduction direct result decreased glands, corroborated marked medium-chain fatty acids pool. Importantly, reduced lipogenic rate not associated with significant changes...
We have stimulated in a cultured hepatocyte system the synergistic interaction between triiodothyronine (T3) and dietary carbohydrate induction of malic enzyme (ME). Kinetic studies revealed that isolated hepatocytes equilibrate with media T3 within 5 min; nuclei by 45 half-time metabolism was 10 h 10% serum. demonstrated nuclear receptors ME physiological concentrations. However, complete absence glucose could still induce ME. At all concentrations (100-1,000 mg/dl), (0.3 nM free T3)...
The major obstacles to the successful use of individual nutritional compounds as preventive or therapeutic agents are their efficacy and bioavailability. One approach overcoming this problem is combinations nutrients induce synergistic effects. objective research was investigate effects two dietary components: docosahexaenoic acid (DHA), an omega-3 fatty present in cold-water fish, curcumin (CCM), herbal nutrient turmeric, vivo model DMBA-induced mammary tumorigenesis mice. We used...
Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in US. It not known whether glucose-lowering medications differentially affect function. Objective To evaluate outcomes Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness (GRADE) trial comparing 4 classes added to metformin for glycemic management individuals with T2D. Design, Setting, and Participants randomized clinical was conducted at 36 sites across included adults T2D less than 10 years, a...
We previously reported that thyroid hormone, 3,3',5-triiodo-l-thyronine (T3), increased Na,K-ATPase activity of adult rat alveolar epithelial cells in a transcription-independent manner via cell surface expression the alpha(1) and beta(1) subunits Na,K-ATPase. Now we sought to identify signaling molecules necessary for T3 stimulation cells. Whereas protein kinase A inhibitor H-8 C bisindolymaleimide did not block T3-induced increase activity, two inhibitors phosphoinositide 3-kinase (PI3K),...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitation of rat liver messenger ribonucleic acid for malic enzyme during induction by thyroid hormoneHoward C. Towle, Cary N. Mariash, Harold L. Schwartz, and Jack H. OppenheimerCite this: Biochemistry 1981, 20, 12, 3486–3492Publication Date (Print):June 9, 1981Publication History Published online1 May 2002Published inissue 9 June 1981https://pubs.acs.org/doi/10.1021/bi00515a028https://doi.org/10.1021/bi00515a028research-articleACS...