Ranee Chatterjee
A5056393981- Diabetes Management and Research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Vitamin D Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atrial Fibrillation Management and Outcomes
- Sodium Intake and Health
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
- Potassium and Related Disorders
- Diabetes and associated disorders
- Diabetes Management and Education
- Pharmacology and Obesity Treatment
- Cardiac electrophysiology and arrhythmias
- Ethics in Clinical Research
- Health Policy Implementation Science
- Cardiac Arrhythmias and Treatments
- Clinical practice guidelines implementation
- Pancreatic function and diabetes
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
Duke University
2016-2025
Milken Institute
2024
George Washington University
2024
MedStar Health
2024
University of Michigan
2023-2024
Kings County Hospital Center
2024
State University of New York
2024
University of Colorado Denver
2024
Kaiser Permanente
2024
Albert Einstein College of Medicine
2024
Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin supplementation lowers diabetes is unknown.We randomly assigned adults who met at least two three glycemic criteria for prediabetes (fasting plasma glucose level, 100 to 125 mg per deciliter; hours after 75-g oral load, 140 199 glycated hemoglobin 5.7 6.4%) no diagnostic receive 4000 IU day D3 or placebo, regardless baseline serum level. The...
Abstract Background: Research participants” feedback about their participation experiences offers critical insights for improving programs. A shared Empowering the Participant Voice (EPV) infrastructure enabled a multiorganization collaborative to collect, analyze, and act on participants’ using validated participant-centered measures. Methods: consortium of academic research organizations with Clinical Translational Science Awards (CTSA) programs administered Perception Survey (RPPS) active...
Abstract Whether initiation of statins could increase survival free dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double‐blind, placebo‐controlled randomized pragmatic clinical trial, will compare high‐intensity statin therapy (atorvastatin 40 mg) with placebo 20,000 community‐dwelling without cardiovascular disease, disability, or at baseline. Exclusion criteria include use the prior year for >5 inability to take statin. Potential participants are identified...
Chronic obstructive pulmonary disease (COPD) is underdiagnosed in primary care.
Serum potassium levels affect insulin secretion by pancreatic β-cells, and hypokalemia associated with diuretic use has been dysglycemia. We hypothesized that adults lower serum dietary intake are at higher risk for incident diabetes mellitus (DM), independent of use.
OBJECTIVE The economic costs of hyperglycemia are substantial. Early detection would allow management to prevent or delay development diabetes and diabetes-related complications. We investigated the justification for screening pre-diabetes/diabetes. RESEARCH DESIGN AND METHODS projected health system societal over 3 years 1,259 adults, comparing associated with five opportunistic tests. All subjects had measurements taken random plasma capillary glucose (RPG RCG), A1C, 1 h after a 50 g oral...
Abstract Context Vitamin D regulates glucose homeostasis pathways, but effects of vitamin supplementation on β-cell function remain unclear. Objective To investigate the D3 insulin sensitivity and function. Methods This is a prespecified secondary analysis Type 2 Diabetes study. Overweight/obese adults at high risk for type diabetes (prediabetes) were randomly treated with 4000 IU or matching placebo daily 24 months. Main Outcome Disposition index (DI), as an estimate function, was...
OBJECTIVE To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity β-cell function. RESEARCH DESIGN AND METHODS In Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) cohort with type 2 diabetes (n = 4,801), HOMA2 was used estimate (HOMA2-%S) fasting function (HOMA2-%B) at baseline 1, 3, 5 years treatment. Oral glucose tolerance test...
We examined longitudinal associations between emotional distress (specifically, depressive symptoms and diabetes distress) medication adherence in Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE), a large randomized controlled trial comparing four glucose-lowering medications added to metformin adults with relatively recent-onset type 2 mellitus (T2DM).
OBJECTIVE We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative other treatments. RESEARCH DESIGN AND METHODS The Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE) of T2DM <10 years’ duration, HbA1c 6.8–8.5%, and taking monotherapy randomly assigned participants add glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist...
OBJECTIVE To describe the individual and joint associations of baseline factors with glycemia, also differential effectiveness medications added to metformin. RESEARCH DESIGN AND METHODS Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes diagnosed for <10 years, on metformin, HbA1c 6.8–8.5%; N = 5,047) were randomly assigned a basal insulin (glargine), sulfonylurea (glimepiride), glucagon-like peptide 1 agonist...
Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects glucose-lowering medications on cardiovascular outcomes individuals diabetes low risk are unclear. We investigated by treatment group participants randomly assigned to insulin glargine, glimepiride, liraglutide, or sitagliptin, added baseline metformin, GRADE (Glycemia Reduction Approaches Type Diabetes: A Comparative Effectiveness Study).
The rising incidence and prevalence of Type 2 diabetes worldwide requires us to try identify the determinants this epidemic improved measures prevent treat condition. While obesity is a major risk factor for diabetes, there are other factors that could potentially be corrected more easily. Potassium, both serum levels lesser extent dietary intake levels, has been associated with incident diabetes. Lower potassium have found higher in some studies. This article will review literature...
Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in US. It not known whether glucose-lowering medications differentially affect function. Objective To evaluate outcomes Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness (GRADE) trial comparing 4 classes added to metformin for glycemic management individuals with T2D. Design, Setting, and Participants randomized clinical was conducted at 36 sites across included adults T2D less than 10 years, a...
Abstract Empowering the Participant Voice (EPV) is an NCATS-funded six-CTSA collaboration to develop, demonstrate, and disseminate a low-cost infrastructure for collecting timely feedback from research participants, fostering trust, providing data improving clinical translational research. EPV leverages validated Research Perception Survey (RPPS) popular REDCap electronic data-capture platform. This report describes development of designed overcome identified institutional barriers routinely...
OBJECTIVE Although screening for diabetes and prediabetes is recommended, it not clear how best or whom to screen. We therefore compared the economics of according baseline risk. RESEARCH DESIGN AND METHODS Five tests were performed in 1,573 adults without known diabetes—random plasma/capillary glucose, glucose 1 h after 50-g oral (any time, previous fast, plasma a challenge [GCTpl]/capillary [GCTcap]), A1C—and definitive 75-g tolerance test. Costs included following: costs testing (screen...
OBJECTIVE GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin people with type 2 (T2DM). We report baseline characteristics and compare participants National Health Nutrition Examination Survey (NHANES) cohort. RESEARCH DESIGN AND METHODS Participants were age ≥30 years at the time of diagnosis, duration T2DM <10 years,...
Background: A single-site study showed that a combined patient and provider intervention improved outcomes for patients with knee osteoarthritis, but it did not assess separate effects of the interventions. Objective: To examine whether patient-based, provider-based, patient–provider interventions improve osteoarthritis outcomes. Design: Cluster randomized trial assignment to patient, provider, or usual care. (ClinicalTrials.gov: NCT01435109) Setting: 10 Duke University Health System...
OBJECTIVE We report mortality outcomes in the Glycemia Reduction Approaches Diabetes: A Comparative Effectiveness Study (GRADE) among people with type 2 diabetes diagnosed within 10 years and no recent history of cardiovascular events or cancer. RESEARCH DESIGN AND METHODS Overall rates major causes death were assessed over an average 5 follow-up. Cause was adjudicated centrally by a committee masked to treatment assignment. examined baseline covariates 10-year Framingham Risk Score for...