A5111498400- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Occupational and environmental lung diseases
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Hippo pathway signaling and YAP/TAZ
- Cancer Research and Treatments
- High Entropy Alloys Studies
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Metal complexes synthesis and properties
- Lipid metabolism and biosynthesis
- Hedgehog Signaling Pathway Studies
- Cytokine Signaling Pathways and Interactions
- Additive Manufacturing Materials and Processes
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
Wuhan National Laboratory for Optoelectronics
2022-2023
Huazhong University of Science and Technology
2022-2023
University of California, San Francisco
2013-2023
UCSF Helen Diller Family Comprehensive Cancer Center
2013-2023
First Affiliated Hospital of Bengbu Medical College
2023
Nanjing University of Information Science and Technology
2022
China Railway Construction Corporation (China)
2022
Nanchang University
2021
Indiana University Health
2010-2015
Indiana University – Purdue University Indianapolis
2010-2015
Lung cancer is the leading cause of death in world, but molecular mechanisms for its development have not been well characterized. The suppressors cytokine signaling (SOCS) are inhibitors that function via Janus kinase (JAK)/signal transducers and activators transcription (STAT) pathway. Eight SOCS proteins with similar structures identified so far. family members, however, distinct inhibition JAK/STAT signaling. Abnormalities pathway associated cancer. Inhibition results growth suppression...
Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety human cancers, and we recently reported importance aberrant Wnt in lung cancer. On other hand, inhibition suppresses growth numerous cell types. inhibitory factor-1 (WIF-1) secreted antagonist that can bind extracellular space inhibit signaling. Recently, down-regulation WIF-1 has been several cancers. To discover mechanism silencing cancer, first identified promoter subsequently examined...
Aberrant activation of the Wingless-type (Wnt)/β-catenin signaling pathway is associated with a variety human cancers. Little known regarding role that Wnt ligands play in carcinogenesis. To test whether Wnt-1 signal survival factor cancer cells and thus may serve as potential therapeutic target, we investigated effect inhibition cell lines, including non small lung cancer, breast mesothelioma, sarcoma. Both monoclonal antibody RNA interference (RNAi) were used to inhibit signaling. We found...
Abstract Recent progress in the development of inhibitors protein-protein interactions has opened door for developing drugs that act by novel and selective mechanisms. Building on work, we designed a small-molecule inhibitor Wnt signaling pathway, which is aberrantly activated across wide range human tumors. The compound, named FJ9, disrupts interaction between Frizzed-7 receptor PDZ domain Dishevelled, down-regulating canonical suppressing tumor cell growth. antitumorigenic effects FJ9 were...
Activation of the Wnt/beta-catenin signaling pathway has been associated with human cancers. To test whether Wnt-2 signal is a survival factor in melanoma cells and thus represents potential therapeutic target, we investigated effects inhibition cell lines. We have developed novel monoclonal antibody against NH(2) terminus ligand that induces apoptosis overexpressing Wnt-2. Whereas incubation this normal lacking expression does not induce apoptosis, blockade by ligand-binding confirmed...
Programmed death-ligand 1 (PD-L1) is a membrane protein on tumor cells that binds to the PD-1 receptor expressed immune cells, leading escape of cells. Yes-associated (YAP) main effector Hippo/YAP signaling pathway, which plays important roles in cancer development. Here we show YAP regulates PD-L1 expression human non-small cell lung (NSCLC) First, investigated and at level 142 NSCLC samples 15 normal samples. In tissue, immunohistochemistry showed positive staining for PD-L1, correlated...
// Ping-Chih Hsu 1, 2, * , Bin You 3, Yi-Lin Yang 1 Wen-Qian Zhang 3 Yu-Cheng Wang Zhidong Xu Yuyuan Dai Shu Liu Cheng-Ta 2 Hui Li Hu David M. Jablons Liang Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University California, San Francisco, CA, USA Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan Beijing Chao-Yang Affiliated with Capital Medical Science, Beijing, People’s Republic China These authors have contributed equally to this...
// Bin You 1, 2, * , Yi-Lin Yang Zhidong Xu 1 Yuyuan Dai Shu Liu Jian-Hua Mao 3 Osamu Tetsu 4 Hui Li 2 David M. Jablons Liang Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University California, San Francisco, CA, USA Thoracic Beijing Chao-Yang Hospital, Affiliated with Capital Medical Science, Beijing, People's Republic China Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, Otolaryngology–Head and Neck These authors have contributed equally...
Saturated fatty acids (SFAs), significant components of both enteral/parenteral nutritional formulations (including diet), are linked to cardiovascular disease complications, such as atherosclerosis. We investigated whether oleic acid (C18:1n-9) reduces the growth inhibitory and pro-inflammatory effects stearic (C18:0) in human aortic endothelial cells (HAEC). Stearic induced inhibition at concentrations less than 50 μM, whereas higher invoked cytotoxicity. acid-induced cytotoxic were...
Abstract Background Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators therapeutic strategy. Therefore, candidate therapeutics must be assessed the context multiple cell lines with known phenotypes. Docosahexaenoic acid (DHA) curcumin (CCM) are dietary compounds to antagonize breast proliferation. We report that these combination exert variable antiproliferative effect across lines, synergistic SK-BR-3 cells triggers signaling...
The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in tumorigenesis. Frequent promoter hypermethylation SFRPs has been identified human cancer. Restoration SFRP attenuates induces apoptosis a variety cancer types. is known to inhibit through activation beta-catenin/Tcf-mediated transcription. Recently, we aberrant result Dishevelled overexpression malignant mesothelioma. Here, report that silencing SFRP4 correlated...