A5012600716- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Cannabis and Cannabinoid Research
- Cellular Mechanics and Interactions
- Lipid metabolism and biosynthesis
- Cancer-related gene regulation
- Adenosine and Purinergic Signaling
- Hedgehog Signaling Pathway Studies
- Oral and Maxillofacial Pathology
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Occupational and environmental lung diseases
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Cancer Research and Treatments
- Axon Guidance and Neuronal Signaling
- Cell death mechanisms and regulation
University of California, San Francisco
2014-2021
Model Animal Research Center
2010-2021
Nanjing University
2010-2021
UCSF Helen Diller Family Comprehensive Cancer Center
2014-2018
Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against glioma; however, molecular target mechanism of action CBD in glioma are poorly understood. Here we investigated mechanisms underlying antitumor effect preclinical models human glioma. Our results showed that induced autophagic rather than apoptotic cell death cells. We also mitochondrial...
Programmed death-ligand 1 (PD-L1) is a membrane protein on tumor cells that binds to the PD-1 receptor expressed immune cells, leading escape of cells. Yes-associated (YAP) main effector Hippo/YAP signaling pathway, which plays important roles in cancer development. Here we show YAP regulates PD-L1 expression human non-small cell lung (NSCLC) First, investigated and at level 142 NSCLC samples 15 normal samples. In tissue, immunohistochemistry showed positive staining for PD-L1, correlated...
// Ping-Chih Hsu 1, 2, * , Bin You 3, Yi-Lin Yang 1 Wen-Qian Zhang 3 Yu-Cheng Wang Zhidong Xu Yuyuan Dai Shu Liu Cheng-Ta 2 Hui Li Hu David M. Jablons Liang Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University California, San Francisco, CA, USA Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan Beijing Chao-Yang Affiliated with Capital Medical Science, Beijing, People’s Republic China These authors have contributed equally to this...
// Bin You 1, 2, * , Yi-Lin Yang Zhidong Xu 1 Yuyuan Dai Shu Liu Jian-Hua Mao 3 Osamu Tetsu 4 Hui Li 2 David M. Jablons Liang Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University California, San Francisco, CA, USA Thoracic Beijing Chao-Yang Hospital, Affiliated with Capital Medical Science, Beijing, People's Republic China Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, Otolaryngology–Head and Neck These authors have contributed equally...
Orchestrated regulation of neuronal migration and morphogenesis is critical for development establishment functional circuits, but its regulatory mechanism incompletely defined. We established analyzed mice with neural-specific knock-out Trio, a guanine nucleotide exchange factor multiple domains. Knock-out showed defective cerebella severe signs ataxia. Mutant had no granule cells in the internal cell layer due to aberrant as well abnormal neurite growth. Trio-deficient reduced extension...
Abstract Malignant mesothelioma is an aggressive cancer that resistant to current therapy. The poor prognosis of has been associated with elevated Yes‐associated protein (YAP) activity. In this study, we evaluated the effect targeting YAP in mesothelioma. First, comprehensively studied activity five cell lines (211H, H2052, H290, MS‐1 and H2452) one normal mesothelial line (LP9). We found decreased phospho‐YAP ratio consistently increased GTIIC reporter 211H, H2052 H290 compared LP9. same...
// Yuyuan Dai 1, * , Shu Liu Wen-Qian Zhang 2 Yi-Lin Yang 1 Phillip Hang Hui Wang Li Cheng Ping-Chih Hsu Yu-Chen Zhidong Xu David M. Jablons Liang You Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University California, San Francisco, CA, USA Beijing Chao-Yang Hospital, Affiliated with Capital Medical Science, Beijing, People's Republic China These authors contributed equally to this work Correspondence to: You, email: Liang.you@ucsfmedctr.org Keywords:...
Abstract Yes‐associated protein ( YAP ) is a main mediator of the Hippo pathway and promotes cancer development progression in human lung cancer. We sought to determine whether inhibition suppresses metastasis adenocarcinoma murine model. found that metastatic NSCLC cell lines H2030‐BrM3(K‐ras G12C mutation) PC 9‐BrM3 EGFR Δexon19 had significantly decreased p‐ (S127)/ ratio compared parental H2030 (K‐ras 9 cells P < .05). H2030‐BrM3 increased mRNA expression downstream genes CTGF CYR 61...
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant several types of cancer including mesothelioma. Protein kinase CK2 affects pathways through the mechanism phosphorylation. mRNA levels CK2α Gli1 were tested by quantitative RT-PCR immunohistochemistry staining mesothelioma samples lines. Down-regulated expression transcriptional activity demonstrated RT-PCR, Western blot luciferase reporter assay. In this study, we show that...
Overcoming temozolomide (TMZ) resistance in glioma cancer cells remains a major challenge to the effective treatment of disease. Increasing TMZ efficacy for patients with glioblastoma (GBM) is urgently needed because standard chemotherapy protocol adult glioblastoma. O6-methylguanine-DNA-methyltransferase (MGMT) overexpression associated resistance, and low MGMT positive response marker therapy. Here, we used 3 cell lines (SF767, U373, LN229), which had different levels sensitivity. We found...
Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 48% the analyzed 73 human tumors, significant correlation expression identified (P<0.05). We evaluated doublecortin-like kinase 1 (DCLK1) tumors. Our results showed that 50.7% immunohistochemistry tumors have DCLK1, its significantly correlated with or Also, upregulation DCLK1 poor prognosis MPM patients...
// Yuyuan Dai 1 , 2 * Hiroyuki Kyoyama 3 Yi-Lin Yang Yucheng Wang Shu Liu Yinghao Jian-Hua Mao 4 Zhidong Xu Kazutsugu Uematsu David M. Jablons and Liang You Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University California, San Francisco, CA, USA Model Animal Research Center Nanjing University, Nanjing, Jiangsu, China Pulmonary Medicine, Saitama Medical Kawagoe, Saitama, Japan Biological Systems Engineering Division, Lawrence Berkeley National Berkeley,...
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant several types of cancer including mesothelioma. Protein kinase CK2 affects pathways through the mechanism phosphorylation. mRNA levels CK2α Gli1 were tested by quantitative RT-PCR immunohistochemistry staining mesothelioma samples lines. Down-regulated expression transcriptional activity demonstrated RT-PCR, Western blot luciferase reporter assay. In this study, we show that...