A5062037997- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Vestibular and auditory disorders
- Diet, Metabolism, and Disease
- Neurogenesis and neuroplasticity mechanisms
- GABA and Rice Research
- Trace Elements in Health
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Iron Metabolism and Disorders
- Alzheimer's disease research and treatments
- Ovarian function and disorders
- Amino Acid Enzymes and Metabolism
- Genetic Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Mast cells and histamine
- Intensive Care Unit Cognitive Disorders
- Autophagy in Disease and Therapy
- Ocular Surface and Contact Lens
Shanghai Jiao Tong University
2024-2025
Nanjing Drum Tower Hospital
2021-2025
Songjiang District Central Hospital
2024-2025
Nanjing University
2014-2024
Soochow University
2024
State Key Laboratory of Pharmaceutical Biotechnology
2018-2024
Pharmaceutical Biotechnology (Czechia)
2018-2024
Second Affiliated Hospital of Soochow University
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against glioma; however, molecular target mechanism of action CBD in glioma are poorly understood. Here we investigated mechanisms underlying antitumor effect preclinical models human glioma. Our results showed that induced autophagic rather than apoptotic cell death cells. We also mitochondrial...
Abstract Microglia play a key role in regulating synaptic remodeling the central nervous system. Activation of classical complement pathway promotes microglia-mediated pruning during development and disease. CD47 protects synapses from excessive development, implicating microglial SIRPα, receptor, remodeling. However, SIRPα disease remains unclear. Here, using conditional knock-out mice, we show that microglia-specific deletion results decreased density. In human tissue, observe expression...
Depressive phenotypes induced by paternal stress can be transferred from one generation to the next via small RNAs in sperm.
Vestibular compensation is responsible for the spontaneous recovery of postural, locomotor, and oculomotor dysfunctions in patients with peripheral vestibular lesion or posterior circulation stroke. Mechanism investigation great importance both facilitating function understanding postlesion functional plasticity adult CNS. Here, we report that postsynaptic histamine H1 receptor contributes greatly to compensation. The expression restrictedly increased ipsilesional rather than contralesional...
Cognitive impairment is a common issue among human patients undergoing surgery, yet the neural mechanism causing this remains unidentified. Surgical procedures often lead to glial cell activation and neuronal hypoexcitability, both of which are known contribute postoperative cognitive dysfunction (POCD). However, role neuron-glia crosstalk in pathology POCD still unclear. Through integrated transcriptomics proteomics analyses, we found that complement cascades microglial phagocytotic...
ABSTRACT Reactive astrocytes play a critical role in the initiation and progression of epilepsy, but their molecular subtypes functional characterization are not fully understood. In this study, we report existence neurotoxic reactive astrocytes, recently identified subtype, that contribute to neuronal death epileptic brain. kainic acid (KA)‐induced mouse model show induced by microglia‐secreted cytokines, including IL‐1α, TNFα, C1q, detectable as early 7 days post‐KA stimulation. These...
Epilepsy, a neurological disorder marked by recurrent, unprovoked seizures, is often linked to dysregulated iron metabolism, resulting in overload and subsequent cellular dysfunction or death within epileptogenic regions. We proposed specific, noninvasive technique using paramagnetic susceptibility imaging via magnetic resonance quantify vivo brain levels, aiming enhance our understanding of epilepsy pathology improve diagnostic accuracy. Our histopathological studies demonstrated that...
Histamine and histamine receptors in the central nervous system actively participate modulation of motor control. In clinic, histamine-related agents have traditionally been used to treat vestibular disorders. Immunohistochemical studies revealed a distribution histaminergic afferents brainstem nuclei, including lateral nucleus (LVN), which is critical for adjustment muscle tone reflexes. However, mechanisms underlying effect on LVN neurons role control are still largely unknown. Here, we...
Abstract Corticotropin releasing factor (CRF), a peptide hormone involved in the stress response, holds key position cardiovascular regulation. Here, we report that central effect of CRF on activities is mediated by posterior hypothalamic nucleus (PH), an important structure responsible for stress-induced changes. Our present results demonstrate directly excites PH neurons via two receptors, CRFR1 and CRFR2 consequently increases heart rate (HR) rather than mean arterial pressure (MAP) renal...
<title>Abstract</title> Reactive astrocytes play a critical role in the pathology of various neurological disorders, often resulting neuronal damage and death. Accumulating evidences demonstrate that reactive astrocyte is an important component glia scar epileptic human brain, but molecular subtyping functional characterization initiation progression epilepsy not fully understood. In this study, we report existence neurotoxic astrocytes, novel defined subtype, are pro-epileptic brain. kainic...