A5085020687- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Cancer-related Molecular Pathways
- Occupational and environmental lung diseases
- Meat and Animal Product Quality
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Oral and Maxillofacial Pathology
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Bone health and osteoporosis research
- Olfactory and Sensory Function Studies
- RNA Research and Splicing
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Food Chemistry and Fat Analysis
- GABA and Rice Research
- Probiotics and Fermented Foods
- Fermentation and Sensory Analysis
- Epigenetics and DNA Methylation
- Coffee research and impacts
- Hedgehog Signaling Pathway Studies
Agency for Science, Technology and Research
2023-2024
University of California, San Francisco
2014-2019
Medical College of Wisconsin
2017-2019
UCSF Helen Diller Family Comprehensive Cancer Center
2014-2019
Threshold Pharmaceuticals (United States)
2016
University of California, San Diego
2012
Programmed death-ligand 1 (PD-L1) is a membrane protein on tumor cells that binds to the PD-1 receptor expressed immune cells, leading escape of cells. Yes-associated (YAP) main effector Hippo/YAP signaling pathway, which plays important roles in cancer development. Here we show YAP regulates PD-L1 expression human non-small cell lung (NSCLC) First, investigated and at level 142 NSCLC samples 15 normal samples. In tissue, immunohistochemistry showed positive staining for PD-L1, correlated...
Abstract Malignant mesothelioma is an aggressive cancer that resistant to current therapy. The poor prognosis of has been associated with elevated Yes‐associated protein (YAP) activity. In this study, we evaluated the effect targeting YAP in mesothelioma. First, comprehensively studied activity five cell lines (211H, H2052, H290, MS‐1 and H2452) one normal mesothelial line (LP9). We found decreased phospho‐YAP ratio consistently increased GTIIC reporter 211H, H2052 H290 compared LP9. same...
Abstract Yes‐associated protein ( YAP ) is a main mediator of the Hippo pathway and promotes cancer development progression in human lung cancer. We sought to determine whether inhibition suppresses metastasis adenocarcinoma murine model. found that metastatic NSCLC cell lines H2030‐BrM3(K‐ras G12C mutation) PC 9‐BrM3 EGFR Δexon19 had significantly decreased p‐ (S127)/ ratio compared parental H2030 (K‐ras 9 cells P < .05). H2030‐BrM3 increased mRNA expression downstream genes CTGF CYR 61...
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant several types of cancer including mesothelioma. Protein kinase CK2 affects pathways through the mechanism phosphorylation. mRNA levels CK2α Gli1 were tested by quantitative RT-PCR immunohistochemistry staining mesothelioma samples lines. Down-regulated expression transcriptional activity demonstrated RT-PCR, Western blot luciferase reporter assay. In this study, we show that...
Nontraditional yeasts prevalent in tropical agricultural fermentations such as coffee and cocoa are known to contribute aroma profiles, yet the functional roles interactions between associated microbial consortia a farm fermentation unclear. Here, boiled green bean extract (GBE) from beans was developed rich screening medium deconstruct their during of dried beans. When cultivated coculture with S. cerevisiae on GBE, strain-specific groupings distinct volatile organic profiles were observed...
Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 48% the analyzed 73 human tumors, significant correlation expression identified (P<0.05). We evaluated doublecortin-like kinase 1 (DCLK1) tumors. Our results showed that 50.7% immunohistochemistry tumors have DCLK1, its significantly correlated with or Also, upregulation DCLK1 poor prognosis MPM patients...
Abstract Malignant pleural mesothelioma (mesothelioma) is a highly aggressive cancer without an effective treatment. Cul4A, scaffold protein that recruits substrates for degradation, amplified in several human cancers, including mesothelioma. We have recently shown Cul4A plays oncogenic role vitro and mouse model. In this study, we analysed clinical tumours found moderate to strong expression of 70.9% (51/72) these tumours, as by immunohistochemistry. 72.2% with increased copy number...
Abstract Cyclin‐dependent kinase 7 (CDK7) is a protein that plays major role in transcription initiation. Yes‐associated (YAP) main effector of the Hippo/YAP signalling pathway. Here, we investigated CDK7 on YAP regulation human malignant pleural mesothelioma (MPM). We found microarray samples MPM tissue, immunohistochemistry staining showed correlation between expression level and (n = 70, r .513). In cells, was significantly correlated with GTIIC reporter activity ( .886, P .019)....
A key factor influencing consumer acceptance of soybean products is the aroma and taste profile, which can be modulated through fermentation using unique microbial strains. This study aimed to identify characterize novel strains with potential enhance flavour profiles including umami, while reducing undesirable notes such as beany aromas. The results showed an 800% (8-fold) increase in free amino acids samples fermented
Abstract Cisplatin is one of the most widely used anticancer agents for treatment an array malignancies. Although multiple mechanisms are involved in cisplatin efficacy, prominent and best understood modes action generation DNA lesions induction apoptosis mitochondrial reactive oxygen species (ROS)-dependent effects on integrity. However, intrinsic or acquired resistance can become a limiting factor cisplatin-based therapy. Evofosfamide hypoxia-activated prodrug that reduced at its...