A5082057646- Cytomegalovirus and herpesvirus research
- Asthma and respiratory diseases
- RNA modifications and cancer
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- RNA regulation and disease
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Toxoplasma gondii Research Studies
- Pneumonia and Respiratory Infections
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Stress, Anesthesia, and Immune Response
- Management of metastatic bone disease
- RNA Interference and Gene Delivery
- Bioinformatics and Genomic Networks
- Head and Neck Cancer Studies
- Pharmacological Effects of Medicinal Plants
- Respiratory viral infections research
- HIV Research and Treatment
- Peptidase Inhibition and Analysis
Shandong Provincial Hospital
2014-2024
Shandong First Medical University
2021-2024
Shandong University
2013-2024
Jinan Infectious Disease Hospital
2021-2024
Jiujiang University
2023
Hanzhong People's Hospital
2021-2022
Wenzhou Medical University
2021-2022
Jinan Central Hospital
2021-2022
Jiangsu Yonggang Group (China)
2021
China Medical University
2011-2017
// Yao Liu 1 , Lili Su Shu-Juan Jiang and Hui Qu 2 Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to University, Jinan, Shandong, China General Surgery, University Qilu Hospital, Correspondence to: Qu, email: doctorquhui@126.com Keywords: non-HIV, pneumocystis pneumonia, risk factor, mortality, meta-analysis Received: April 20, 2017 Accepted: July 26, Published: August 04, 2017 ABSTRACT The number patients with non-human...
Abstract Metastasis accounts for the majority of cases cancer recurrence and death in patients with advanced non-small cell lung (NSCLC). Farnesoid X Receptor (FXR) is a bile acid nuclear receptor that was recently found to be upregulated NSCLC tissues. However, whether how FXR regulates metastasis remains unclear. In present study, it promoted migration, invasion, angiogenic ability cells vitro, increased mouse model vivo. Mechanistic investigation demonstrated specifically bound promoters...
Background Cough is a common symptom during and after COVID-19 infection; however, few studies have described the cough profiles of COVID-19. Objective The aim this study was to investigate prevalence, severity, associated risk factors severe persistent in individuals with latest wave Omicron variant China. Methods In nationwide cross-sectional study, we collected information characteristics from infection SARS-CoV-2 using an online questionnaire sent between December 31, 2022, January 11,...
Background CalliSpheres are drug‐eluting beads used for tumor artery embolization, with clinical benefits in a number of cancer types. The aim the study was to examine and complications patients stage II–IV lung treated embolization versus conventional vascular interventional treatment. Methods This prospective cohort conducted from August 2018 May 2019. were grouped according traditional bronchial arterial infusion chemotherapy (infusion group) or chemoembolization loaded adriamycin...
Lung cancer is the leading cause of death and its incidence ranked high in men women worldwide. Non-small-cell lung (NSCLC) adenocarcinoma one most frequent histological subtypes cancer. The aberration profile molecular mechanism driving progression are key for precision therapy cancer, while screening biomarkers essential to early diagnosis treatment In this work, we applied a bioinformatics method analyze dysregulated interaction network microRNA-mRNA NSCLC, based on both gene expression...
Increasing evidence suggests that human antigen R (HuR) is involved in the epithelial-mesenchymal transition (EMT) process of several diseases. However, role HuR EMT airway epithelial cells patients with COPD remains unclear. BEAS-2B were cultured and treated 3%CSE. Western blotting, RT-PCR immunofluoresence used to detect expression HuR, ZEB-1. RNAi was suppress expression. Then knockdown blotting showed siHuR-1 siHuR-3, clear suppression confirmed. We chose most effective one, proceed...
During infection with human cytomegalovirus (HCMV), overexpression of hcmv‐miR‐US33 can inhibit the lytic viral replication and down‐regulate US29 mRNA. However, it remains unknown whether inhibition by miR‐US33 is mediated down‐regulation expression or another host gene. Here, we identified gene Syntaxin3 ( STX3 ) to be a direct target hcmv‐miR‐US33‐5p using Hybrid‐PCR luciferase‐reporter assays. It was further demonstrated that levels protein were down‐regulated in...
Histone deacetylase (HDAC) inhibitors combined with other drugs for the treatment of malignant tumors are used more and widely. In this study, we investigated effect trichostatin A (TSA), a HDAC inhibitor, in combination cisplatin, cytotoxic chemotherapy agent, on apoptosis lung cancer A549 cells.A549 cells were treated TSA alone, cisplatin alone or two combined. Cell viability evaluated using light microscope, methyl thiazolyl tetrazolium (MTT) (3-[4, 5-dimethylthiazol-2-yl] -2,...
The human cytomegalovirus (HCMV) encodes ≥26 microRNAs (miRNAs). These miRNAs are utilized by HCMV to regulate its own genes in addition the of host cell, during infection. present study first identified p21‑activated kinase 2 (PAK2) as a target hcmv‑miR‑US4‑5p, via hybrid polymerase chain reaction, which was further verified using luciferase reporter assay. protein expression level PAK2, detected western blotting, demonstrated be directly downregulated overexpression hcmv‑miR‑US4‑5p HEK293,...
Lung cancer consists of two main subtypes: small-cell lung (SCLC) and non-small-cell (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach identify molecular biomarkers can distinguish SCLC from NSCLC. By identifying positive negative coexpression gene pairs in normal tissues, SCLC, or NSCLC samples using functional association information the STRING network, first construct cancer-specific network. From obtain...
Asthma is a worldwide health burden with an alarming prevalence. For years, asthma-associated airway injury remains elusive. Transforming growth factor β1 (TGF-β1) pleiotropic cytokine that has been shown to be involved in the synthesis of matrix molecules associated remodeling. Human antigen R (HuR), member Hu RNA-binding protein family, can bind subset short-lived mRNAs their 3' untranslated regions (UTR). However, functional roles and relevant signaling pathways HuR remodeling have not...
Objective: To investigate the current status of diagnosis and treatment pulmonary cryptococcosis in respiratory medicine improve understanding clinical characteristics HIV-negative China. Methods: A prospective multi-center open cohort study was designed to screen for general wards intensive care units Department Respiratory Diseases 22 hospitals. The patients with positive cryptococcal etiological based on smear culture, antigen detection histopathology were enrolled study. data collected...
A human monoclonal antibody (MAb) (2F5) neutralizing a variety of laboratory strains and clinical isolates the immunodeficiency virus type 1 (HIV-1) binding to an epitope envelope glycoprotein gp41 encompassing amino acid sequence ELDKWA has been described (Muster T et al., J Virol 1993;67:6642–6647). It was suggested that immunogen eliciting virus-neutralizing antibodies having specificity similar MAb 2F5 should be considered as component HIV-1 vaccines. Efforts in this direction would...
Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, is oral targeted anticancer drug that used to treat non-small cell lung cancer (NSCLC). Previous studies have confirmed erlotinib safe and well-tolerated by patients. The most common adverse reactions observed following treatment include a rash mild diarrhea. In the current study, first case of acute myocardial infarction one month with in 63-year-old male NSCLC patient presented. present study highlights importance...