A5007328363- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Nutritional Studies and Diet
- Liver Disease and Transplantation
- Analytical chemistry methods development
- Marine Biology and Environmental Chemistry
- Peroxisome Proliferator-Activated Receptors
- Polymer Nanocomposites and Properties
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Lipid metabolism and disorders
- Metabolism and Genetic Disorders
- Muscle metabolism and nutrition
- Pancreatitis Pathology and Treatment
- Eating Disorders and Behaviors
- Free Radicals and Antioxidants
- Cholesterol and Lipid Metabolism
- Regulation of Appetite and Obesity
- Organometallic Compounds Synthesis and Characterization
- Nutrition and Health in Aging
University of Missouri
2015-2024
Columbia College - Missouri
2020-2021
Canadian Society for Exercise Physiology
2021
St. Elizabeth Healthcare
2020
Hawaii Biotech (United States)
2020
University of Missouri Health System
2018-2019
University of North Carolina at Chapel Hill
2019
The University of Texas Southwestern Medical Center
2006-2016
Pfizer (United States)
2016
Harry S. Truman Memorial Veterans' Hospital
2015
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess triacylglycerol (TAG), inflammation, and damage. The goal present study was to directly quantify biological sources hepatic plasma lipoprotein TAG in NAFLD. Patients (5 male 4 female; 44 ± 10 years age) scheduled for a medically indicated biopsy were infused with orally fed stable isotopes days label track serum nonesterified acids (NEFAs), dietary acids, those derived from de novo lipogenesis (DNL)...
Mitochondria are critical for respiration in all tissues; however, liver, these organelles also accommodate high-capacity anaplerotic/cataplerotic pathways that essential to gluconeogenesis and other biosynthetic activities. During nonalcoholic fatty liver disease (NAFLD), mitochondria produce ROS damage hepatocytes, trigger inflammation, contribute insulin resistance. Here, we provide several lines of evidence indicating induction biosynthesis through hepatic is energetically backed by...
NAFLD and its more-advanced form, steatohepatitis (NASH), is associated with obesity an independent risk factor for cardiovascular, liver-related, all-cause mortality. Available human data examining hepatic mitochondrial fatty acid oxidation (FAO) turnover in NASH are scant.To investigate this relationship, liver biopsies were obtained from patients undergoing bariatric surgery clustered into four groups based on histopathological classification: Control (CTRL; no disease); NAFL (steatosis...
Low-fat, high-carbohydrate (LF/HC) diets commonly elevate plasma triglyceride (TG) concentrations, but the kinetic mechanisms responsible for this effect remain uncertain. Subjects with low TG (normolipidemic [NL]) and those moderately elevated (hypertriglyceridemic [HTG]) were studied on both a control an LF/HC diet. We measured VLDL particle transport rates, nonesterified fatty acid (NEFA) flux, sources of acids used assembly VLDL-TG. The diet resulted in 60% elevation TG, 37% reduction...
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess triacylglycerol (TAG), inflammation, and damage. The goal present study was to directly quantify biological sources hepatic plasma lipoprotein TAG in NAFLD. Patients (5 male 4 female; 44 ± 10 years age) scheduled for a medically indicated biopsy were infused with orally fed stable isotopes days label track serum nonesterified acids (NEFAs), dietary acids, those derived from de novo lipogenesis (DNL)...
The liver's regulation of fatty acids (FAs) postprandially may contribute to risk metabolic diseases.Measurements steady-state metabolism were used investigate sources FAs for very low-density lipoprotein (VLDL)-triacylglycerol (TG) synthesis during fasting and feeding in vivo.Subjects duodenally fed a formula labeled with the stable isotope glyceryl tri-palmitate-d(31) iv infused [1,2,3,4-(13)C(4)]-palmitatic acid [1-(13)C(1)]-acetate quantitate use originating from adipose tissue de novo...
We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism.With two parallel approaches-a fat body-specific green fluorescent protein enhancer trap screen D. melanogaster expression profiling developing murine tissues-we identified Atf4 as expressed vertebrate metabolic tissues. assessed the functional relevance evolutionarily conserved by analyzing mutant flies mice for possible phenotypes.Flies with insertions at locus have reduced...
Repletion of lean body mass (LBM) that patients lose in human immunodeficiency virus (HIV) infection has proved difficult. In healthy, HIV-seronegative men, synergy between progressive resistance exercise (PRE) and very high-dose testosterone therapy been reported for gains LBM muscle strength.To determine whether a moderately supraphysiologic androgen regimen, including an anabolic steroid, would improve strength PRE HIV-infected men with prior weight loss protease inhibitor antiretroviral...
Objective: We aimed at determining the relationship of gut microbiota and short chain fatty acids with obesity fat partitioning testing potential differences in ability to ferment equal amounts carbohydrates (CHO) between lean obese youth. Research Design Methods: analyzed 84 youth whom body distribution was measured by fast-magnetic resonance imaging, de novo lipogenesis (DNL) quantitated using deuterated water, capability flora CHO assessed 13C-fructose treatment vitro. Results: A...
Elevated hepatic de novo lipogenesis (DNL) is a key distinguishing characteristic of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis. In rodent models NAFLD, treatment with surrogate TVB-2640, pharmacological acid synthase inhibitor, has been shown to reduce fat other biomarkers DNL. The purpose this phase I clinical study was test the effect TVB-2640 in obese men certain metabolic abnormalities that put them at risk for NAFLD.Twelve subjects (mean ± SEM, 42 2 years, body mass...
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation that can progress to inflammation (nonalcoholic steatohepatitis, NASH), and fibrosis. Serum β-hydroxybutyrate (β-HB), a product of the ketogenic pathway, commonly used as surrogate marker for hepatic acid oxidation (FAO). However, it remains uncertain whether this relationship holds true in context NAFLD humans. We compared fasting serum β-HB levels with direct measurement mitochondrial palmitate humans...