A5057809355- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Infectious Aortic and Vascular Conditions
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Cardiac Imaging and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Mechanical Circulatory Support Devices
- Peripheral Nerve Disorders
- Estrogen and related hormone effects
- Stroke Rehabilitation and Recovery
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Nerve Injury and Rehabilitation
- Heat shock proteins research
- Sepsis Diagnosis and Treatment
University of Pennsylvania
2006-2024
King's College Hospital NHS Foundation Trust
2023-2024
King's College London
2024
Guy's and St Thomas' NHS Foundation Trust
2022-2024
Harefield Hospital
2022-2024
King's College Hospital
2023
David Grant USAF Medical Center
2022
Grant Medical Center
2022
London North West Healthcare NHS Trust
2020
Northwick Park Hospital
2020
The aim of this study was to assess the significance malperfusion syndromes in patients with acute type A aortic dissection following a contemporary surgical management algorithm and effects on morbidity, hospital mortality, long-term survival. We believe that obliteration primary tear site restoration flow true lumen results decreased need for revascularization malperfused organ systems.Our operative approach aims at replacing entire ascending aorta, resuspension valve repair or replacement...
Background and Purpose —The aim of our study was to determine whether the National Institutes Health Stroke Scale (NIHSS) can be estimated retrospectively from medical records. The NIHSS is a quantitative measure stroke-related neurological deficit with established reliability validity for use in prospective clinical research. Recently, retrospective observational studies have scores records outcome analysis. estimation based on chart review has not been determined. Methods —Thirty-nine...
Childhood onset motor neuron diseases or neuronopathies are a clinically heterogeneous group of disorders. A particularly severe subgroup first described in 1894, and subsequently called Brown-Vialetto-Van Laere syndrome, is characterized by progressive pontobulbar palsy, sensorineural hearing loss respiratory insufficiency. There has been no treatment for this neurodegenerative disorder, which leads to failure usually death during childhood. We recently reported the identification SLC52A2,...
To examine the effect of an integrated surgical approach to treatment acute type A dissections.Acute dissection requires surgery prevent death from proximal aortic rupture or malperfusion. Most series past decade have reported a rate in range 15% 30%.From January 1994 March 2001, 104 consecutive patients underwent repair dissection. All had operative management as follows: intraoperative transesophageal echocardiography; hypothermic circulatory arrest (HCA) with retrograde cerebral perfusion...
<i>Background and Relevance:</i> Atherosclerotic stenosis of the major intracranial arteries is an important cause transient ischemic attack (TIA) or stroke. Of 900,000 patients who suffer a TIA stroke each year in USA, responsible for approximately 10%, i.e. 90,000 patients. There have been no prospective trials evaluating antithrombotic therapies preventing recurrent vascular events these The main objective this trial to compare warfarin [International Normalized Ratio (INR)...
Abstract Nephrogenic fibrosing dermopathy (NFD), a newly recognized scleroderma‐like disease, was originally described as purely cutaneous disorder. More widespread involvement, including fibrosis of pulmonary and cardiac tissues, has been documented only recently, it suggested that more appropriate designation is dialysis‐associated systemic fibrosis. We report five cases this novel disorder, spanning spectrum primarily skin to muscle involvement. Clinical, radiological,...
Abstract Aim of Study: To characterize the cerebral embolic exposure during transfemoral (TF) and transapical (TA) TAVR. Methods: detect events TAVR, intraoperative neuromonitoring using transcranial Doppler (TCD) was utilized in 28 patients (Edwards SAPIEN valve TF n = 18, TA 10). High intensity transient signals (HITS) reflective were recorded. Results: The mean age 83.4 ± 7.4 years. Society Thoracic Surgeons predicted risk mortality score 11.7 2.9. total number HITS TAVR not significantly...
To directly compare dynamic susceptibility contrast (DSC) and continuous arterial spin labeled (CASL) magnetic resonance (MR) perfusion techniques in patients with known cerebrovascular disease, the goals of identifying possible pitfalls interpretation determining potential for a complementary role this setting.DSC CASL MR studies were performed compared 11 acute and/or chronic disease. Using an automated segmentation technique, Pearson correlation coefficients generated measurements to DSC...
The 15-item National Institutes of Health Stroke Scale (NIHSS) is a quantitative measure stroke-related neurological deficit with established reliability and validity for use in clinical research. An abridged 11-item modified NIHSS (mNIHSS) has been described that simplifies or eliminates redundant less reliable items. We aimed to determine whether the mNIHSS could be accurately abstracted from medical records facilitate retrospective research.We selected 39 patient which scores were...