A5078774647- Advanced MRI Techniques and Applications
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- MRI in cancer diagnosis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Acute Ischemic Stroke Management
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Health and Disease Prevention
- High Altitude and Hypoxia
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Intensive Care Unit Cognitive Disorders
- Atomic and Subatomic Physics Research
- Cardiac Arrest and Resuscitation
- Cancer, Hypoxia, and Metabolism
Morehouse College
2025
The University of Texas Southwestern Medical Center
2018-2024
Southwestern Medical Center
2023
Southwestern University
2021
Rainbow Babies & Children's Hospital
2020
Children's Hospital Colorado
2020
University of Colorado Denver
2020
Thomas Jefferson University
2020
State University of New York
2014-2017
Stony Brook University Hospital
2012-2017
The incidence and impact of clinical stroke silent radiographic cerebral infarction complicating open surgical aortic valve replacement (AVR) are poorly characterized.We performed a prospective cohort study subjects ≥65 years age who were undergoing AVR for calcific stenosis. Subjects evaluated by neurologists preoperatively postoperatively underwent postoperative magnetic resonance imaging. Over 4-year period, 196 enrolled at 2 sites (mean age, 75.8±6.2 years; 36% women; 6% nonwhite)....
Breathing 100% O 2 at 1 atmosphere absolute (ATA) is known to be associated with a decrease in cerebral blood flow (CBF). It also accompanied by fall arterial Pco leading uncertainty as whether the vasoconstriction totally or only part caused hypocapnia. We tested hypothesis that increase Po while was breathed 1.0 ATA decreases CBF independently of concurrent . measured seven healthy men aged 21–62 yr using noninvasive continuous spin-labeled-perfusion MRI. The tracer this technique,...
Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) arterial spin labeled perfusion MRI (ASL-MRI). The DCS ASL-MRI data exhibited highly correlated absolute relative dynamic responses each individual (p < 0.001). Peak variations hyperemia were also significantly correlated, though more for 0.003) than 0.016) flow. Repeated measurement variation less 8% both modalities....
The effect of hypercapnia on cerebral metabolic rate oxygen consumption ( CMRO 2 ) has been a subject intensive investigation and debate. Most applications are based the assumption that mild increase in partial pressure carbon dioxide negligible metabolism. In this study, we sought to further investigate vascular effects by simultaneously measuring global venous saturation S v O total blood flow tCBF), with temporal resolution 30 seconds using magnetic resonance susceptometry phase-contrast...
To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals.CASL MRI CBF on a 1.5-T GE Signa magnet were repeated in young healthy male and female subjects at one hour week. Precision measurement was evaluated both time yielded within-subject coefficients variation (wsCV) 5.8% for global 13% individual vascular regions when within hour. Differences these...
We employed near-infrared optical techniques, diffuse correlation spectroscopy (DCS), and frequency-domain (FD-NIRS) to test the hypothesis that supervised exercise training increases skeletal muscle microvascular blood flow oxygen extraction in patients with peripheral artery disease (PAD) who experience claudication. PAD ( n = 64) were randomly assigned control groups. Patients group received 3 mo of training. Calf optically monitored before, during, after performance a graded treadmill...
The function of the peripheral microvascular may be interrogated by measuring perfusion, tissue oxygen concentration, or venous saturation (SvO2) recovery dynamics following induced ischemia. purpose this work is to develop and evaluate a magnetic resonance (MR) technique for simultaneous measurement SvO2, skeletal muscle T2*. Perfusion, Intravascular Venous Oxygen saturation, T2* (PIVOT) comprised interleaved pulsed arterial spin labeling (PASL) multi-echo gradient-recalled echo (GRE)...
In Drosophila melanogaster genetic screens are often used to identify genes associated with different biological processes. Here, we have utilized the Flp/FRT system generate mitotic clones within developing eye. These were screened for mutations that disrupt cell division, organ patterning, and growth. One such mutation from this screen, mutant M.3.2, resulted in an expansion of cuticle area normally covered by ommatidium as well overall smaller eye size. Genetic molecular mapping revealed...
Postoperative cognitive dysfunction occurs frequently after cardiac, major vascular, and orthopedic surgery. Aging hypertensive cerebrovascular disease are leading risk factors for this disorder. Acute anemia, common to surgery, has been identified as a possible contributor postoperative dysfunction. The effect of hypoxia upon cognition the cellular molecular processes involved in learning memory well described. Cerebrovascular changes related chronic hypertension may expose cells increased...
Endothelial dysfunction present in patients with peripheral artery disease may be better understood by measuring the temporal dynamics of blood flow and oxygen saturation during reactive hyperemia than conventional static measurements.
Abstract An accurate noninvasive method to measure the hemoglobin oxygen saturation (% HbO 2 ) of deep‐lying vessels without catheterization would have many clinical applications. Quantitative MRI may be only imaging modality that can address this difficult and important problem. MR susceptometry–based oximetry for measuring blood in large models vessel as a long paramagnetic cylinder immersed an external field. The intravascular magnetic susceptibility relative surrounding muscle tissue is...
Spinal cord ischemia can lead to paralysis or paraparesis, but if detected early it may be amenable treatment. Current methods use evoked potentials for detection of spinal ischemia, a decades old technology whose warning signs are indirect and significantly delayed from the onset ischemia. Here we introduce demonstrate prototype fiber optic device that directly measures blood flow oxygenation. This technical advance in neurological monitoring promises new standard care opportunity...
Background and Purpose— Stroke is a potentially devastating complication of cardiac surgery. Identifying predictors radiographic infarct may lead to improved stroke prevention for surgical patients. Methods— We reviewed 129 postoperative brain magnetic resonance imagings from prospective study patients undergoing aortic valve replacement. Acute infarcts were classified as watershed or embolic using prespecified criteria. Results— on imaging was seen in 79 (61%), interrater reliability...