A5041840962- Cardiac, Anesthesia and Surgical Outcomes
- Blood transfusion and management
- Diabetes Treatment and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Erythropoietin and Anemia Treatment
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Venous Thromboembolism Diagnosis and Management
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Cardiac Imaging and Diagnostics
- Hemoglobin structure and function
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
St. Michael's Hospital
2016-2025
Unity Health Toronto
2019-2025
University of Toronto
2016-2025
St Michael’s Hospital
2003-2024
Toronto Public Health
1998-2023
St Michael's Hospital
2020-2023
St Michaels Hospital
1999-2022
University of Alberta
2009-2022
Institute of Medical Sciences
2022
Alberta Health Services
2022
There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS).
As more patients survive the acute respiratory distress syndrome, an understanding of long-term outcomes this condition is needed.We evaluated 109 survivors syndrome 3, 6, and 12 months after discharge from intensive care unit. At each visit, were interviewed underwent a physical examination, pulmonary-function testing, six-minute-walk test, quality-of-life evaluation.Patients who survived young (median age, 45 years) severely ill Acute Physiology, Age, Chronic Health Evaluation score, 23)...
Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and reduce exposure blood products. We sought determine whether aprotinin was superior either tranexamic acid or aminocaproic in decreasing massive postoperative other clinically important consequences.In this multicenter, blinded trial, we randomly assigned 2331 high-risk surgical patients one of three groups: 781 received aprotinin, 770 acid, 780 acid. The primary outcome bleeding. Secondary outcomes...
A strategy of mechanical ventilation that limits airway pressure and tidal volume while permitting hypercapnia has been recommended for patients with the acute respiratory distress syndrome. The goal is to reduce lung injury due overdistention. However, efficacy this approach not established.
Background— Acute kidney injury (AKI) after cardiac surgery is a major health issue. Lacking effective therapies, risk factor modification may offer means of preventing this complication. The objective the present study was to identify and determine prognostic importance such factors. Methods Results— Data from multicenter cohort 3500 adult patients who underwent at 7 hospitals during 2004 were analyzed (using multivariable logistic regression modeling) independent relationships between 3...
The effect of a restrictive versus liberal red-cell transfusion strategy on clinical outcomes in patients undergoing cardiac surgery remains unclear.In this multicenter, open-label, noninferiority trial, we randomly assigned 5243 adults who had European System for Cardiac Operative Risk Evaluation (EuroSCORE) I 6 or more (on scale from 0 to 47, with higher scores indicating risk death after surgery) threshold (transfuse if hemoglobin level was <7.5 g per deciliter, starting induction...
Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with fibrillation, but this not proved. The procedure can be performed during cardiac surgery undertaken for other reasons.
Rationale: Little is known about the long-term outcomes and costs of survivors acute respiratory distress syndrome (ARDS).Objectives: To describe functional quality life outcomes, health care use, ARDS 2 yr after intensive unit (ICU) discharge.Methods: We recruited a cohort from four academic tertiary ICUs in Toronto, Canada, prospectively monitored them ICU admission to discharge.Measurements: Clinical direct medical costs.Results: Eighty-five percent patients with discharged survived yr;...
SGLT2 (sodium-glucose cotransporter 2) inhibitors lower cardiovascular events in type 2 diabetes mellitus but whether they promote direct cardiac effects remains unknown. We sought to determine if empagliflozin causes a decrease left ventricular (LV) mass people with and coronary artery disease.Between November 2016 April 2018, we recruited 97 individuals ≥40 ≤80 years old glycated hemoglobin 6.5% 10.0%, known disease, estimated glomerular filtration rate ≥60mL/min/1.73m2. The participants...
We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to liberal with respect the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure dialysis by hospital discharge 28 days after surgery, whichever came first. now report clinical outcomes 6 months surgery.
Cerebral oxygen desaturation during cardiac surgery has been associated with adverse perioperative outcomes. Before a large multicenter randomized controlled trial (RCT) on the impact of preventing desaturations outcomes, authors undertook prospective, parallel-arm, feasibility RCT to determine whether an intervention algorithm could prevent desaturations.Eight Canadian sites 201 patients between April 2012 and October 2013. The primary outcome was success rate reversing cerebral below 10%...
Bleeding after cardiac surgery is a common and serious complication leading to transfusion of multiple blood products resulting in increased morbidity mortality. Despite the publication numerous guidelines consensus statements for patient management surgery, research has revealed that adherence these poor, as result, significant variability practices among practitioners still remains. In addition, although utilization point-of-care (POC) coagulation monitors use novel therapeutic strategies...
Intraoperative electroencephalogram (EEG) waveform suppression, suggesting excessive general anesthesia, has been associated with postoperative delirium.