A5102964607- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Blood transfusion and management
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Dermatology and Skin Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Respiratory Support and Mechanisms
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Tuberculosis Research and Epidemiology
Guy's and St Thomas' NHS Foundation Trust
2010-2024
Yale University
2021-2024
King's College London
2020-2024
Jefferson Hospital
2024
University Hospitals of Leicester NHS Trust
2018-2023
Eastbourne District General Hospital
2023
Queen Victoria Hospital NHS Foundation Trust
2021
Guy's Hospital
2021
University of Pennsylvania
2011-2020
Penn Center for AIDS Research
2020
Background: Conscious sedation is used during transcatheter aortic valve replacement (TAVR) with limited evidence as to the safety and efficacy of this practice. Methods: The National Cardiovascular Data Registry Society Thoracic Surgeons/American College Cardiology Transcatheter Valve Therapy was characterize anesthesia choice clinical outcomes all US patients undergoing elective percutaneous transfemoral TAVR between April 1, 2014, June 30, 2015. Raw inverse probability treatment-weighted...
Bleeding after cardiac surgery is a common and serious complication leading to transfusion of multiple blood products resulting in increased morbidity mortality. Despite the publication numerous guidelines consensus statements for patient management surgery, research has revealed that adherence these poor, as result, significant variability practices among practitioners still remains. In addition, although utilization point-of-care (POC) coagulation monitors use novel therapeutic strategies...
The identification of disease alleles underlying human autoinflammatory diseases can provide important insights into the mechanisms that maintain neutrophil homeostasis. Here, we focused our attention on generalized pustular psoriasis (GPP), a potentially life-threatening disorder presenting with cutaneous and systemic neutrophilia. Following whole-exome sequencing 19 unrelated affected individuals, identified subject harboring homozygous splice-site mutation (c.2031-2A>C) in MPO. This...
Prophylactic ureteric stenting in renal transplantation reduces major urological complications; however, morbidity is related to the indwelling duration of a stent. We aimed determine optimal for stents this clinical setting. Patients (aged 2-75 years) from six UK hospitals who were undergoing recruited and randomly assigned either early stent removal at 5 days (without cystoscopy) or late 6 weeks after (with cystoscopy). The primary outcome was composite stent-related complications defined...
Background The care pathway for patients undergoing transcatheter aortic valve replacement (TAVR), particularly in the US, was initially based on open surgical techniques and often includes general anesthesia, transesophageal echocardiographic monitoring, cardiothoracic intensive unit (ICU) stays. Whether a subgroup of could benefit from early extubation, fewer days ICU, ambulation terms both cost effectiveness is unknown. Methods Results A fast track (FT) protocol initiated at two...
The main conventional systemic treatments for atopic dermatitis (AD) are methotrexate (MTX) and ciclosporin (CyA). Dupilumab was the first novel agent to enter routine clinical practice. There no head-to-head randomized controlled trials or real-world studies comparing these agents directly. Network meta-analyses provide indirect comparative efficacy safety data have shown strong evidence dupilumab CyA.
Excessive perioperative bleeding is associated with major complications in cardiac surgery, resulting increased morbidity, mortality, and cost. An international expert panel was convened to develop consensus statements on the control of management transfusion suggest key quality metrics for surgical bleeding. The reviewed relevant literature from previous 10 years used a modified RAND Delphi methodology achieve consensus. developed 30 8 categories, including prioritizing bleeding, prechest...
Although palmoplantar pustulosis (PPP) can significantly impact quality of life, the factors underlying disease severity have not been studied.To examine associated with PPP severity.An observational, cross-sectional study 2 cohorts was conducted. A UK data set including 203 patients obtained through Anakinra in Pustular Psoriasis, Response a Controlled Trial (2016-2019) and its sister research Elucidating Underlying Mechanisms (2016-2020). Northern European cohort 193 independently...
Palmoplantar pustulosis (PPP) is a rare, debilitating, chronic inflammatory skin disease that affects the hands and feet. Clinical, immunological genetic findings suggest pathogenic role for interleukin (IL)-1.
When clinicians consider extracorporeal life support (ECLS) for acute respiratory distress syndrome (ARDS) patients with hemodynamic instability, both veno-arterial (VA) and veno-venous (VV) ECLS are therapeutic possibilities. We analyzed 17 ARDS on inotropic or vasopressor requiring refractory hypoxemia. After implementing VV ECLS, pressor requirements (based norepinephrine equivalents) were significantly lower in all (P = .0001 overall comparison across time points). None of the required...