A5008416983- Optimal Experimental Design Methods
- Statistical Methods in Clinical Trials
- Maternal Mental Health During Pregnancy and Postpartum
- Meta-analysis and systematic reviews
- Adolescent and Pediatric Healthcare
- Probabilistic and Robust Engineering Design
- Advancements in Transdermal Drug Delivery
- Advanced Multi-Objective Optimization Algorithms
- Child and Adolescent Psychosocial and Emotional Development
- Dialysis and Renal Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Drug Delivery Systems
- Breastfeeding Practices and Influences
- Maternal and Perinatal Health Interventions
- Childhood Cancer Survivors' Quality of Life
- Mechanical Circulatory Support Devices
- Advanced Statistical Process Monitoring
- Cardiac, Anesthesia and Surgical Outcomes
- Family and Patient Care in Intensive Care Units
- Organ Transplantation Techniques and Outcomes
- Blood transfusion and management
- Eating Disorders and Behaviors
- Family Support in Illness
- Genomics and Phylogenetic Studies
- Transplantation: Methods and Outcomes
Monash University
2022-2025
Vanderbilt University Medical Center
2025
The University of Queensland
2012-2024
Minnesota Orthopedic Sports Medicine Institute
2024
Royal Brisbane and Women's Hospital
2023-2024
Australian Regenerative Medicine Institute
2023
King's College London
2015-2022
Kidney Health Australia
2021-2022
Centre for Health Technology and Services Research
2022
Boston Medical Center
2021
There is limited evidence on the prevalence and identification of antenatal mental disorders. Aims To investigate disorders in early pregnancy diagnostic accuracy depression-screening (Whooley) questions compared with Edinburgh Postnatal Depression Scale (EPDS), against Structured Clinical Interview DSM-IV-TR.Cross-sectional survey women responding to Whooley asked at their first appointment. Women positively a random sample negatively were invited participate.Population was 27% (95% CI...
Abstract At local scales, infectious disease is a common driver of population declines, but globally it an infrequent contributor to species extinction and endangerment. For at risk from important questions remain unanswered, including when does become threat co‐occur, predictably, with other threats? Using newly compiled data the International Union for Conservation Nature (IUCN) Red List, we examined relative role co‐occurrence threats associated amphibians, birds, mammals 6 levels (i.e.,...
Background and Objectives Excessive bleeding is a risk associated with cardiac surgery. Treatment invariably requires transfusion of blood products; however, the itself may contribute to postoperative sequelae. Our objective was analyse quality initiative designed provide an evidenced‐based approach management. Materials Methods A retrospective analysis compared product patient outcomes 15 months before after implementation management protocol. The protocol incorporated point‐of‐care...
Delayed graft function (DGF) is traditionally defined as the requirement for dialysis during first week after transplantation. DGF a common complication of renal transplantation, and it negatively affects short- long-term outcomes. Ischaemia reperfusion injury (IRI) prime contributor to development DGF. It well established that complement system activation plays pivotal role in pathogenesis IRI. Mirococept highly effective inhibitor can be administered ex vivo donor kidney just before...
Objective To estimate the population prevalence of anxiety disorders during pregnancy and investigate diagnostic accuracy two-item Generalised Anxiety Disorder scale (GAD-2) for a) GAD b) any disorder. Design Cross-sectional survey using a stratified sampling design. Sampling weights were used in analysis to adjust bias introduced by sampling. Setting Inner-city maternity service, South London. Participants 545 pregnant women interviewed after their first antenatal appointment; 528 provided...
Objective This study reports follow-up data from a multicenter randomized controlled trial (n = 142) comparing the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients broadly defined anorexia nervosa (AN). At 12 months postrandomization, all patients had statistically significant improvements body mass index (BMI), eating disorder (ED) symptomatology and other outcomes no differences between groups. MANTRA was...
Increasing evidence suggests that postnatal paternal depression is associated with adverse emotional, behavioural and cognitive outcomes in children. Despite this, few studies have determined the prevalence of fathers' depressive symptoms during first years their children's lives explored what factors are related to these symptoms. We estimated examined risk a nationally representative sample fathers children aged between 9 months 7 old from Millennium cohort study. The were maternal...
Prophylactic ureteric stenting in renal transplantation reduces major urological complications; however, morbidity is related to the indwelling duration of a stent. We aimed determine optimal for stents this clinical setting. Patients (aged 2-75 years) from six UK hospitals who were undergoing recruited and randomly assigned either early stent removal at 5 days (without cystoscopy) or late 6 weeks after (with cystoscopy). The primary outcome was composite stent-related complications defined...
Abstract Background There is a growing interest in the use of Bayesian adaptive designs late-phase clinical trials. This includes stopping rules based on analyses which frequentist type I error rate controlled as group-sequential designs. Methods paper presents practical comparison and tests. Focussing setting data can be summarised by normally distributed test statistics, we evaluate compare boundary values operating characteristics. Results Although approaches are fundamentally different...
ABSTRACT Objective Symptoms of chronic fatigue syndrome (CFS) can be perpetuated by cognitive and behavioral responses to the illness. We aimed determine factor structure, reliability, validity 40-item Cognitive Behavioural Responses Questionnaire (CBRQ) using data gathered from CFS patients. also propose a short-version CBRQ for greater clinical utility. Methods The psychometric analysis was performed on sets drawn two sources: service patients ( n = 576) PACE randomized controlled trial...
Utility functions in Bayesian experimental design are usually based on the posterior distribution. When is found by simulation, it must be sampled from for each future dataset drawn prior predictive Many thousands of distributions often required. A popular technique literature, which rapidly obtains samples posterior, importance sampling, using as However, sampling will tend to break down if there a reasonable number observations. In this paper, we explore use Laplace approximations setting...
Big Datasets are endemic, but often notoriously difficult to analyse because of their size, heterogeneity and quality.The purpose this paper is open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by very nature have traditionally been applied prospectively, improve analysis Data through retrospective designed sampling in order answer particular questions interest.By appealing range examples, it suggested that perspective modelling has...
Background Young women aged 16–24 are at high risk of common mental disorders (CMDs), but the during pregnancy is unclear. Aims To compare population prevalence CMDs in pregnant with ≥25 years a representative cohort, hypothesising that younger higher (depression, anxiety disorders, post-traumatic stress disorder, obsessive–compulsive disorder), and this associated low social support, rates lifetime abuse unemployment. Method Analysis cross-sectional baseline data from cohort 545 (of whom 57...
Bayesian adaptive designs can improve the efficiency of trials, and lead to trials that produce high quality evidence more quickly, with fewer patients lower costs than traditional methods. The aim this work was determine how be constructed for phase III clinical in critical care, assess influence would have on trial study results. We re-designed High Frequency OSCillation Acute Respiratory distress syndrome (OSCAR) using design methods, allow possibility early stopping success or futility....
To estimate prevalence of lifetime and current eating disorders (ED) in a sample pregnant women South-East London to describe their sociodemographic clinical characteristics.Secondary analysis data from cross-sectional survey. Using stratified sampling design, 545 were recruited. Diagnostic interviews administered assess ED, depression, anxiety, borderline personality disorder. Data extracted maternity records identification ED antenatal care. Estimates population obtained using weights...
Abstract Background Bayesian adaptive methods are increasingly being used to design clinical trials and offer several advantages over traditional approaches. Decisions at analysis points usually based on the posterior distribution of treatment effect. However, there is some confusion as whether control type I error required for designs this a frequentist concept. Methods We discuss arguments against adjusting multiplicities in with interim analyses. With two case studies we illustrate effect...
Rationale: Randomised clinical trials in intensive care often prioritize disease-focused outcomes rather than patient-centred outcomes. Objective: To report and evaluate the 'Daily Organ Support for patients on extracorporeal membrane oxygenation (ECMO)', DOSE outcome. This is a new longitudinal ordinal outcome receiving ECMO. Methods: Prospective, multicentre study 28 hospitals Australia New Zealand. Adult admitted to participating ICU between February 2019 September 2023 who underwent any...