A5006503105- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Nanocluster Synthesis and Applications
- Cardiac and Coronary Surgery Techniques
- Crystal Structures and Properties
- Quantum Dots Synthesis And Properties
- Atrial Fibrillation Management and Outcomes
- Blood transfusion and management
- Anesthesia and Sedative Agents
- Acute Myocardial Infarction Research
- Airway Management and Intubation Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Global Health Workforce Issues
- Ultrasound in Clinical Applications
- Organometallic Compounds Synthesis and Characterization
- Radiology practices and education
- Cardiac Health and Mental Health
- Enhanced Recovery After Surgery
- Respiratory Support and Mechanisms
- Hemostasis and retained surgical items
University of Ottawa
2015-2025
Ministry of Health
2024
Faculty of 1000 (United States)
2022
Cleveland Clinic
2022
RELX Group (United States)
2022
Los Robles Hospital & Medical Center
2022
Ottawa Hospital
2019-2021
Cho Ray Hospital
2020
Committee on Publication Ethics
2018
University of Toronto
2004-2016
Bacterial communities in the airways of cystic fibrosis (CF) patients are, as other ecological niches, influenced by autogenic and allogenic factors. However, our understanding microbial colonization younger versus older CF association with pulmonary function is rudimentary at best. Using a phylogenetic microarray, we examine airway microbiota age stratified ranging from neonates (9 months) to adults (72 years). From cohort clinically stable patients, demonstrate that who exhibit poorer...
Cardiac surgery is frequently complicated by coagulopathic bleeding that difficult to optimally manage using standard hemostatic testing. We hypothesized point-of-care testing within the context of an integrated transfusion algorithm would improve management coagulopathy in cardiac and thereby reduce blood transfusions.We conducted a pragmatic multicenter stepped-wedge cluster randomized controlled trial point-of-care-based consecutive patients undergoing with cardiopulmonary bypass at 12...
Intraoperative electroencephalogram (EEG) waveform suppression, suggesting excessive general anesthesia, has been associated with postoperative delirium.
Excessive bleeding is a common complication of cardiac surgery. An important cause acquired hypofibrinogenemia (fibrinogen level <1.5-2.0 g/L), for which guidelines recommend fibrinogen replacement with cryoprecipitate or concentrate. The 2 products have differences, but comparative clinical data are lacking.To determine if concentrate noninferior to treatment related after surgery.Randomized trial at 11 Canadian hospitals enrolling adult patients experiencing clinically significant and...
We examined whether perceived unfair treatment is associated with health conditions, social support moderates this association, and such relationships differ by location.Data were derived from the 1998-1999 Filipino American Community Epidemiological Study, a cross-sectional investigation of 2241 Americans living in San Francisco Honolulu. Negative binomial regression was used to examine potential 2-way 3-way interactions between support, treatment, city (San vs Honolulu).Reports increased...
Frailty is increasing in prevalence and poses a formidable challenge for clinicians. The cardiac surgery literature consists primarily of small single-center studies with limited follow-up, the epidemiological features frailty remain to be elucidated long-term follow-up.
Postoperative atrial fibrillation (POAF) is associated with early and late morbidity mortality of cardiac surgical patients. Prophylactic treatment (AF) has been recommended to improve outcome in patients at high risk developing POAF. Reliable models for prediction POAF are needed achieve that goal. This study attempted externally validate 3 proposed preoperative patients: the score, CHA2DS2-VASc Atrial Fibrillation Risk Index.This was a prospective cohort 1416 adult who underwent...
WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Research into major bleeding during cardiac surgery is challenging due to variability in how it scored. Two consensus-based clinical scores for bleeding: the Universal definition of perioperative and European Coronary Artery Bypass Graft (E-CABG) severity grade, were compared this substudy Transfusion Avoidance Cardiac Surgery (TACS) trial.As part TACS, 7,402 patients underwent at 12 hospitals from 2014 2015. We examined content validity...
Objective: To evaluate the short-term outcomes of percutaneous closure ventricular septal defects in patients all age. Summary: Ventricular defect (VSD) is most common congenital heart and can be detected during prenatal postnatal period. In 1987, Lock et al first applied technique interventional occlusion VSD using devices through a catheter this method quickly spread worldwide. Compared with surgery to repair VSD, intervention occlude septum helps minimize complications after procedure,...
Importance Perioperative bleeding is a major concern in patients receiving ticagrelor for acute coronary syndromes (ACS) when artery bypass graft (CABG) surgery required. Objective To evaluate whether early CABG at 2 to 3 days after cessation noninferior waiting 5 7 days. Design, Setting, and Participants RAPID was noninferiority, open-label randomized trial with 6 months of follow-up. were ACS who had received required CABG. Patients enrolled tertiary centers Canada between January 2016...
Excessive bleeding is a common and prognostically important complication of cardiac surgery. For related to coagulation factor deficiency, frozen plasma the most used therapy. Preliminary trials indicate that 4-factor prothrombin complex concentrate (PCC) may be suitable alternative. To compare efficacy safety PCC with in patients undergoing surgery coagulopathic bleeding. Unblinded randomized noninferiority controlled clinical trial at 12 hospitals Canada US involving adults (≥18 years) who...
Abstract Background Demand for rehabilitation services is expected to increase due factors such as an aging population, workforce pressures, rise in chronic and complex multi-system disorders, advances technology, changes interprofessional health service delivery models. However, human resource (HHR) strategies Canadian professionals are lagging behind other professional groups physicians nurses. The objectives of this study were: 1) identify recruitment retention including occupational...
Two copper-mercury-chalcogenide clusters [Hg(15)Cu(20)E(25)(PPr(3))(18)] (1, E = S; 2, Se) are synthesized in good yield from the reaction of (Pr(3)P)(3)Cu-ESiMe(3) and (Pr(3)P)(2).Hg(OAc)(2) at low temperatures. Single-crystal X-ray analyses illustrate that two ternary isomorphous consist a phosphine-stabilized core mixed Hg, Cu, centers. Thermolysis 1 leads to formation mercury metal various forms copper-sulfide. The copper-indium-sulfide cluster [Cu(6)In(8)S(13)Cl(4)(PEt(3))(12)] (3) is...
Background: Clinical outcomes in acute coronary syndrome patients treated with P2Y 12 inhibitors who require urgent artery bypass grafting (CABG) have not been well studied. Methods: We examined clinical relation to the timing of CABG following inhibitor discontinuation (<72 h, 72 h five days, >5 days). The primary ischemic outcome was a composite death, reinfarction, need for revascularization, or stroke. safety bleeding at least moderate severity as defined by Universal Definition...
The European System for Cardiac Operative Risk Evaluation (EuroSCORE) and the Anesthesia (CARE) score are risk indices designed in mid-1990s to predict mortality after cardiac surgery. This study assesses their ability provide risk-adjusted a contemporary surgical population. probability was estimated with additive logistic EuroSCORE, CARE score, 3818 patients undergoing surgery at one institution between 1 April 2006 31 March 2009. Model discrimination obtained using area under receiver...
The copper−chalogenolates (R3P)3Cu−ESiMe3 (E = S, 1; Se, 2; Te, 3; R Et, a; nPr, b) have been prepared in high yield from (R3P)3CuOAc and E(SiMe3)2 at low temperatures. Complexes 1−3 contain a pendant −SiMe3 moiety bonded to chalcogen center. These copper−chalcogenolates are clear, colorless, low-melting-point solids characterized by single-crystal crystallographic spectroscopic methods.
BackgroundCoagulopathy in cardiac surgery is frequently associated with acquired hypofibrinogenaemia, which can be treated either purified fibrinogen concentrate (FC) or cryoprecipitate. Because the latter not and therefore contains additional coagulation factors, it thought to more effective for treatment of coagulopathy that occurs after prolonged cardiopulmonary bypass (CPB). We examined impact CPB duration on efficacy two therapies surgery.MethodsThis was a post hoc analysis Fibrinogen...