A5088090381- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Angiogenesis and VEGF in Cancer
- Cardiac pacing and defibrillation studies
- Ultrasound in Clinical Applications
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Cardiovascular Disease and Adiposity
- Cardiac and Coronary Surgery Techniques
- Heart Failure Treatment and Management
- Cardiac tumors and thrombi
- Aortic Disease and Treatment Approaches
- Cardiac electrophysiology and arrhythmias
University of Ottawa
2016-2025
Mayo Clinic
2021-2025
Mayo Clinic in Arizona
2023-2025
Ottawa Heart Institute
2015-2024
Wilfrid Laurier University
2024
Beth Israel Deaconess Medical Center
2024
Harvard University
2024
Society of Interventional Radiology
2022
Capital Group (United States)
2015-2022
Ottawa University
2022
Cardiogenic shock is associated with substantial morbidity and mortality. Although inotropic support a mainstay of medical therapy for cardiogenic shock, little evidence exists to guide the selection agents in clinical practice.
Cardiogenic shock secondary to acute myocardial infarction (AMI-CS) is associated with substantial short-term mortality; however, there are limited data on long-term outcomes and trends.This study sought examine of AMI-CS patients.This was a population-based, retrospective cohort in Ontario, Canada critically ill adult patients who were admitted hospitals between April 1, 2009 March 31, 2019. Outcome captured using linked health administrative databases.A total 9,789 consecutive from 135...
<h3>Importance</h3> Among patients with ST-segment elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention (PCI), a survival benefit associated radial access compared femoral remains controversial. <h3>Objective</h3> To assess whether there is when used instead of among STEMI PCI. <h3>Design, Setting, and Participants</h3> This multicenter, open-label, randomized clinical trial was conducted at 5 PCI centers in Canada. In total, 2292 were enrolled...
The aim of this study was to evaluate the outcome transcatheter mitral valve repair (TMVr) in patients with cardiogenic shock and significant regurgitation (MR). Patients severe MR have a poor prognosis setting conventional medical therapy. Because its favorable safety profile, TMVr is being increasingly used as an acute therapy population, though efficacy remains unknown. A multicenter, collaborative, patient-level analysis conducted. moderate (3+) or (4+) who were not surgical candidates...
<h3>Importance</h3> Comatose survivors of out-of-hospital cardiac arrest experience high rates death and severe neurologic injury. Current guidelines recommend targeted temperature management at 32 °C to 36 for 24 hours. However, small studies suggest a potential benefit targeting lower body temperatures. <h3>Objective</h3> To determine whether moderate hypothermia (31 °C), compared with mild (34 improves clinical outcomes in comatose arrest. <h3>Design, Setting, Participants</h3>...
Background Recent studies have shown improved outcomes in cardiogenic shock through protocols directed toward early identification and initiation of mechanical circulatory support. However, objective therapeutic targets-based on clinical and/or laboratory data-to guide real-time decision making are lacking. Lactate clearance has been suggested as a potential treatment target because its independent association with mortality. Methods Results In post hoc analysis the DOREMI (Dobutamine...
Up to 50% of patients undergoing mitral transcatheter edge-to-edge repair (MTEER) have an indication for left atrial appendage occlusion (LAAO). However, prospective evaluation this strategy is lacking. The aim the study was prospectively evaluate outcomes combined LAAO and MTEER. WATCH-TEER a multicenter registry that aims assess feasibility safety concomitant MTEER with MitraClip WATCHMAN-FLX in approved clinical both procedures. primary endpoint composite all-cause mortality, stroke,...
Thrombus formation on intracardiac devices remains a subject of importance, with rates in the 2-5% range. Device-related thrombus (DRT) following left atrial appendage occlusion is an area particular concern considering its association embolic events. DRT continues to present numerous questions, including optimal definition, incidence, risk factors, monitoring, therapy, and clinical outcomes - all subjects ongoing assessment. Herein, we discuss these considerations, building upon relevant...
Heart failure (HF) is associated with both mortality and a significant decline in health status. Interatrial shunting increasingly being investigated as novel therapeutic option. The ALT FLOW Early Feasibility Study was designed to evaluate the safety of Edwards left atrial coronary sinus APTURE Transcatheter Shunt System patients symptomatic HF. A total 18 centers enrolled HF pulmonary capillary wedge pressure >15 mm Hg at rest or 25 during exercise. Between May 2018 September 2022, 87...
Open science is a movement and set of practices to conduct research more transparently. Implementing open will significantly improve public access supports equity. It also has the potential foster innovation reduce duplication through data materials sharing. Here, we survey an international group researchers publishing in cardiovascular journals regarding their perceptions related science.