Robert C. Welsh
A5003117663- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Atomic and Subatomic Physics Research
- Infective Endocarditis Diagnosis and Management
- Particle physics theoretical and experimental studies
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Peripheral Artery Disease Management
- Cardiovascular and exercise physiology
- Advanced NMR Techniques and Applications
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Quantum, superfluid, helium dynamics
- Cardiac, Anesthesia and Surgical Outcomes
University of Alberta
2016-2025
Canadian VIGOUR Centre
2016-2025
Alberta Hospital Edmonton
2012-2024
AstraZeneca (Canada)
2016-2024
UCLA Health
2023
Campbell Collaboration
2023
Clinical Trial Investigators
2022
Toronto Public Health
2011-2021
Population Health Research Institute
2015-2021
University of Alberta Hospital
2000-2021
In patients with ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) of the culprit lesion reduces risk cardiovascular death or infarction. Whether PCI nonculprit lesions further such events is unclear.
It is not known whether prehospital fibrinolysis, coupled with timely coronary angiography, provides a clinical outcome similar to that primary percutaneous intervention (PCI) early after acute ST-segment elevation myocardial infarction (STEMI).Among 1892 patients STEMI who presented within 3 hours symptom onset and were unable undergo PCI 1 hour, randomly assigned either or fibrinolytic therapy bolus tenecteplase (amended half dose in ≥75 years of age), clopidogrel, enoxaparin before...
During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested that improves surrogate clinical outcomes, but a larger trial has reported conflicting results.We randomly assigned 10,732 patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI to strategy of routine upfront versus alone. The outcome was composite death from cardiovascular causes, recurrent...
Whether the direct factor Xa inhibitor rivaroxaban can prevent thromboembolic events after transcatheter aortic-valve replacement (TAVR) is unclear.
In Brief Objective Convergent research demonstrates disrupted attention and heightened threat sensitivity in posttraumatic stress disorder (PTSD). This might be linked to aberrations large-scale networks subserving the detection of salient stimuli (i.e., salience network [SN]) stimulus-independent, internally focused thought default mode [DMN]). Methods Resting-state brain activity was measured returning veterans with without PTSD (n = 15 each group) healthy community controls 15)....
Spontaneous coronary artery dissection (SCAD) was underdiagnosed and poorly understood for decades. It is increasingly recognized as an important cause of myocardial infarction (MI) in women. We aimed to assess the natural history SCAD, which has not been adequately explored. performed a multicentre, prospective, observational study patients with non-atherosclerotic SCAD presenting acutely from 22 centres North America. Institutional ethics approval patient consents were obtained. recorded...
<h3>Importance</h3> After percutaneous coronary intervention (PCI), patients with<i>CYP2C19*2</i>or<i>*3</i>loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection oral P2Y12 inhibitor therapy improves outcomes is unknown. <h3>Objective</h3> To determine the effect a strategy on in<i>CYP2C19</i>LOF carriers after PCI. <h3>Design, Setting, and Participants</h3> Open-label randomized clinical trial 5302 undergoing PCI...
We report on a precision measurement of the neutron spin structure function ${g}_{1}^{n}$ using deep inelastic scattering polarized electrons by ${}^{3}\mathrm{He}$. For kinematic range $0.014<x<0.7$ and $1<{Q}^{2}<17(\mathrm{GeV}/c{)}^{2}$, we obtain $\ensuremath{\int}{0.014}^{0.7}{g}_{1}^{n}(x)dx\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}\ensuremath{-}0.036\ifmmode\pm\else\textpm\fi{}0.004(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}0.005(\mathrm{syst})$ at an average...
In young, healthy people the alveolar-arterial P(O(2)) difference (A-aDO(2)) is small at rest, but frequently increases during exercise. Previously, investigators have focused on ventilation/perfusion mismatch and diffusion abnormalities to explain impairment in gas exchange, as significant physiological intra-pulmonary shunt has not been found. The aim of this study was use a non-gas exchange method determine if anatomical (I-P) shunts develop exercise, and, so, whether there relationship...
Despite clinical reports of cognitive deficits associated with cancer chemotherapy, the underlying brain mechanisms are not clear. This research examined selective attention and working memory using functional magnetic resonance imaging (fMRI) in women before chemotherapy for localized breast cancer. Patients were tested an established task during fMRI. Compared healthy controls, patients showed (a) bilateral activation high-demand conditions recruitment additional components...
We aimed to assess the impact of eplerenone on cardiovascular (CV) outcomes in STEMI without known heart failure, when initiated within 24 h symptom onset. In this randomized, placebo-controlled, double-blind trial, we assigned 1012 patients with acute and a history failure receive either (25–50 mg once daily) or placebo addition standard therapy. The primary endpoint was composite CV mortality, re-hospitalization, or, extended initial hospital stay, due diagnosis HF, sustained ventricular...