A5012416570- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Angiogenesis and VEGF in Cancer
- Cardiac and Coronary Surgery Techniques
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Renal and Vascular Pathologies
- Central Venous Catheters and Hemodialysis
- Congenital heart defects research
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Vitamin D Research Studies
Hamilton Health Sciences
2024
Radboud University Medical Center
2024
St Mary's Hospital
2024
Radboud University Nijmegen
2024
Population Health Research Institute
2024
Sorbonne Université
2024
University of California, San Diego
2016-2018
University of Ottawa
2007-2018
Icahn School of Medicine at Mount Sinai
2018
American Heart Association
2017
BackgroundMineralocorticoid receptor antagonists have been shown to reduce mortality in patients after myocardial infarction with congestive heart failure. Whether routine use of spironolactone is beneficial uncertain.MethodsIn this multicenter trial a 2-by-2 factorial design, we randomly assigned who had undergone percutaneous coronary intervention receive either or placebo and colchicine placebo. The results the are reported here. two primary outcomes were composite death from...
Congestive heart failure (CHF) is a disease that characterized by progressive left ventricular (LV) dysfunction and dilatation. Oxidative stress thought to contribute the progression of CHF, antioxidants have been shown beneficial effects when started early after myocardial infarction (MI). In this study, we tested whether powerful antioxidant probucol would attenuate CHF once it was established MI in rat.Ligation coronary artery used create an rats (n=266). Survivors were then randomized 20...
<h3>BACKGROUND:</h3> Radial artery access is commonly performed for coronary angiography and invasive hemodynamic monitoring. Despite limitations in diagnostic accuracy, the modified Allen test (manual occlusion of radial ulnar arteries followed by release latter assessment palmar blush) used routinely to evaluate collateral circulation hand and, therefore, determine patient eligibility access. We sought whether a smartphone application may provide superior alternative test....
Objectives Recent clinical trials suggest an LDL-independent superiority of intensive statin therapy in reducing target vessel revascularization and peri-procedural myocardial infarctions patients who undergo percutaneous coronary interventions (PCI). While animal studies demonstrate that statins mobilize endothelial progenitor cells (EPCs) which can enhance arterial repair attenuate neointimal formation, the precise explanation for PCI benefits high dose remain elusive. Thus we serially...
Elevated fibrinogen is associated with short-term major adverse cardiovascular events (MACE) after percutaneous coronary intervention, but the relation late MACE unknown.Baseline demographics and 2-year were recorded among subjects undergoing nonemergent intervention. A total of 332 (66.6±19.5 years, 69.9% male, 25.3% acute syndrome) enrolled. Two-year (periprocedural myocardial infarction 9.0%, rehospitalization 6.3%, revascularization 12.7%, non-periprocedural 4.5%, stent thrombosis 0.9%,...
Endothelial progenitor cells (EPCs) are circulating pluripotent vascular capable of enhancing re-endothelialization and diminishing neointima formation following arterial injury. Glycogen synthase kinase (GSK)-3beta is a protein that has been implicated in the regulation cell biology. We hypothesized EPC abundance function could be enhanced with use an inhibitor GSK-3beta (GSKi), thereby resulting improved repair.Human EPCs were expanded ex vivo, treated specific GSKi, then assessed for both...
Summary Ticagrelor has been endorsed by guidelines as the P2Y12 inhibitor of choice in patients with acute coronary syndrome. Clinically, some on ticagrelor will require a switch to clopidogrel; however, optimal strategy and pharmacodynamics effects switching remain unknown. Patients an indication were randomly assigned either bolus arm (Clopidogrel 600 mg followed 75 daily, n=30) or no-bolus n=30). Blood samples collected at baseline, 12, 24, 48, 54, 60 72 hours (h) for assessment platelet...
S100A1 is a small Ca(2+)-binding protein expressed in the myocardium and blood vessels that downregulated diseased heart plays role regulation of cardiac muscle Ca(2+) homeostasis contractility. To understand its physiological under basal conditions after myocardial infarction (MI), we used mouse strain with targeted deletion gene [S100A1 knockout (KO) mice]. We compared 49 wild-type (WT) 56 KO mice (6-8 wk old) over 28 days MI sham-operated controls. also examined effect deficiency on...
The adoption of the transradial (TR) approach over traditional transfemoral (TF) has been hampered by concerns increased radiation exposure-a subject considerable debate within field. We performed a patient-level, multi-center analysis to definitively address impact TR access on exposure.Overall, 10 centers were included from 6 countries-Canada (2 centers), United Kingdom (2), Germany Sweden Hungary (1), and Netherlands (1). compared exposure versus TF using measured dose-area product (DAP)....
In patients undergoing primary percutaneous coronary intervention (PPCI) ticagrelor is superior to clopidogrel in reducing cardiovascular events. This study sought evaluate the effect of pretreatment on pharmacodynamics PPCI.We measured platelet reactivity using VerifyNow P2Y12 assay at baseline, 1, 2, 4, 6, 12, 24, and 48 hours following bolus previously loaded with (C+T) thienopyridine-naive (T) referred our centre for PPCI.In total, 52 consecutive eligible ST-elevation myocardial...
Angiotensin receptor blockers (ARBs) reduce adverse left ventricular (LV) remodeling and improve LV function survival when started postmyocardial infarction (MI). ARBs also arrhythmias during ischemia-reperfusion injury pre-MI. No information exists regarding their efficacy safety pre-MI continued peri- post-MI. We evaluated whether the ARB losartan improves outcome Male Wistar rats ( n = 502) were treated for 7 days with at a high dose (30 mg·kg −1 ·day ), progressively increasing (3...