A5039623989- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Vascular Procedures and Complications
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Radiation Dose and Imaging
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Structural Anomalies and Repair
- Renal and Vascular Pathologies
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
University of California, San Diego
2016-2025
UC San Diego Health System
2017-2024
Oregon Health & Science University
2023
Heart Rhythm Society
2023
Clinical Trial Investigators
2022
Colorado State University
2022
Thomas Jefferson University Hospital
2021
La Jolla Alcohol Research
2021
West Virginia University
2020
Cairo University
2018
Left atrial appendage occlusion (LAAO) has emerged as an alternative to anticoagulation for select patients with fibrillation; however, women have been underrepresented in clinical trials of LAAO, and sex-specific subanalyses are limited.To evaluate the sex differences baseline characteristics undergoing LAAO implant in-hospital outcomes after implant.A total 49 357 National Cardiovascular Data Registry Watchman device between January 1, 2016, June 30, 2019, were included this study.Female...
We previously demonstrated pre-B-cell colony enhancing factor (PBEF) as a biomarker in sepsis and sepsis-induced acute lung injury (ALI) with genetic variants conferring ALI susceptibility.To explore mechanistic participation of PBEF ventilator-induced (VILI).Two models VILI were utilized to the role using either recombinant or PBEF(+/-) mice.Initial vitro studies human (rhPBEF) direct rat neutrophil chemotactic vivo demonstrating marked increases bronchoalveolar lavage (BAL) leukocytes...
Patients with aortic valve stenosis (AVS) experience fibrosis and/or calcification in tissue, which leads to heart failure if left untreated. Inflammation is a hallmark of AVS, and secreted cytokines from pro-inflammatory macrophages are thought contribute fibro-calcification by driving the activation valvular interstitial cells (VICs) myofibroblasts. However, molecular mechanisms inflammatory differentially regulate myofibroblast as function biological sex not fully defined. Here, we...
Elevated fibrinogen is associated with short-term major adverse cardiovascular events (MACE) after percutaneous coronary intervention, but the relation late MACE unknown.Baseline demographics and 2-year were recorded among subjects undergoing nonemergent intervention. A total of 332 (66.6±19.5 years, 69.9% male, 25.3% acute syndrome) enrolled. Two-year (periprocedural myocardial infarction 9.0%, rehospitalization 6.3%, revascularization 12.7%, non-periprocedural 4.5%, stent thrombosis 0.9%,...
Abstract Objectives To assess the long‐term safety and efficacy of robotic percutaneous coronary revascularization for use in complex lesions. Background Robotically assisted intervention (PCI) is safe feasible simple lesions has excellent short‐term procedural clinical outcomes lesions; however, are unknown. Methods A total 103 consecutive patients underwent a 108 (R)‐PCI procedures (age 68.1; 78.3% male) over 18 months, 210 226 manual (M)‐PCI 67.5; 78.1% during same period. Patients were...
Abstract Objective To determine trends in real‐world utilization and in‐hospital adverse events from Watchman implantation since its approval by the Food Drug Administration 2015. Background The risk of embolic stroke caused atrial fibrillation is reduced oral anticoagulants, but not all patients can tolerate long‐term anticoagulation. Left appendage occlusion with device has emerged as an alternative therapy. Methods This was a retrospective cohort study utilizing data National Inpatient...
BackgroundLeft atrial appendage occlusion has shown promise in mitigating the risk of stroke selected patients with fibrillation.ObjectiveThe purpose this study was to determine real-world prevalence and in-hospital outcomes left (Watchman) recipients complicated by pericardial effusion requiring percutaneous drainage or open cardiac surgery–based intervention.MethodsData were derived from National Inpatient Sample database January 2015 December 2017. The primary assessed intervention...
Background: Left atrial appendage occlusion using a Watchman device has shown promise in reducing stroke risk selected fibrillation patients. Limited data exist on differences characteristics and in-hospital outcomes of recipients the United States based race/ethnicity. Methods: Data were extracted from National Inpatient Sample database for calendar years 2015 to 2018. The study sample was stratified into 4 groups (White, Black, Hispanic, other races). Baseline characteristics, procedural...
Left atrial appendage occlusion (LAAO) has emerged as an alternative strategy to oral anticoagulation for mitigating ischemic stroke risk in selected patients with fibrillation (AF), but safety data significant kidney disease are limited.To determine the association of chronic (CKD) and end-stage renal (ESRD) procedural complications in-hospital outcomes after LAAO AF patients.Data were extracted from National Inpatient Sample calendar years 2015-2018. Watchman implantations identified on...
Background and aimsLipoprotein(a) [Lp(a)] is causally associated with aortic valve stenosis (AS) but Lp(a) testing among AS patients not broadly incorporated into clinical practice. We evaluated trends in an academic medical center.MethodsEducational efforts adding to the lipid panel on electronic record (EMR) pre-procedure order sets were used increase awareness of as a risk factor AS. Medical records at University California San Diego Health (UCSDH) analyzed from 2010 2020 define yearly...